Printing biological solutions through laser-induced forward transfer

Duocastella, Martí; Fernández-Pradas, J.M.; Domínguez, Jon Eunan Quinlivan; Serra, P.; Morenza, J.L.

doi:10.1007/s00339-008-4741-6

Cited by 61 publications

(38 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2͒ presents an upward trend with a clear linear increase, as it has also been observed in prior works. 9,15,20 The droplet diameter, which sets the resolution of the technique, plotted versus the laser fluence ͑Fig. 2͒ also presents an upward trend, but the increase is not linear.…”

Section: A Microarray Characterizationmentioning

confidence: 99%

“…10 Moreover, LIFT can be used for printing different complex materials, such as inorganic inks or pastes, 11 organic polymers, 12 and even biological solutions. 8,[13][14][15] The feasibility of the technique for depositing these materials has been proved through the fabrication of diverse functional devices such as microbatteries, 11 solar cells, 16 organic light-emitting diodes, 17 or biosensors. 18,19 Such interesting features prompted several studies on the transfer process which takes place during the LIFT of liquids.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 Such interesting features prompted several studies on the transfer process which takes place during the LIFT of liquids. These studies 9,10,14,15,20 were mainly focused on the analysis of the effects that different technological parameters have on the morphology of the transferred material. This allowed improving the performance of the technique, although it also revealed the need for the elucidation of the transfer mechanisms in order to set the basis for parameters optimization.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Time-resolved imaging of the laser forward transfer of liquids

Duocastella¹,

Fernández-Pradas²,

Morenza³

et al. 2009

Journal of Applied Physics

Self Cite

136

View full text Add to dashboard Cite

Time-resolved imaging is carried out to study the dynamics of the laser-induced forward transfer of an aqueous solution at different laser fluences. The transfer mechanisms are elucidated, and directly correlated with the material deposited at the analyzed irradiation conditions. It is found that there exists a fluence range in which regular and well-defined droplets are deposited. In this case, laser pulse energy absorption results in the formation of a plasma, which expansion originates a cavitation bubble in the liquid. After the further expansion and collapse of the bubble, a long and uniform jet is developed, which advances at a constant velocity until it reaches the receptor substrate. On the other hand, for lower fluences no material is deposited. In this case, although a jet can be also generated, it recoils before reaching the substrate. For higher fluences, splashing is observed on the receptor substrate due to the bursting of the cavitation bubble. Finally, a discussion of the possible mechanisms which lead to such singular dynamics is also provided.

show abstract

Section: A Microarray Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Time-resolved imaging of the laser forward transfer of liquids

Duocastella¹,

Fernández-Pradas²,

Morenza³

et al. 2009

Journal of Applied Physics

Self Cite

136

View full text Add to dashboard Cite

show abstract

“…In this approach, the material of interest is dissolved or suspended in a liquid, and submitted to LIFT, leading to the deposition of the solution/suspension in the form of microdroplets. A great variety of complex materials has been successfully printed through LIFT: nanoparticle inks for electrodes in transistors [7,8], polymers for chemical sensors [9], biomolecule solutions for biosensors [10][11][12][13], or even living cells for tissue engineering applications [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Film-free laser forward printing of transparent and weakly absorbing liquids

et al. 2010

Self Cite

View full text Add to dashboard Cite

A laser-based technique for printing transparent and weakly absorbing liquids is developed. Its principle of operation relies in the tight focusing of short laser pulses inside the liquid and close to its free surface, in such a way that the laser radiation is absorbed in a tiny volume around the beam waist, with practically no absorption in any other location along the beam path. If the absorbed energy overcomes the optical breakdown threshold, a cavitation bubble is generated, and its expansion results in the propulsion of a small fraction of liquid which can be collected on a substrate, leading to the printing of a microdroplet for each laser pulse. The technique does not require the preparation of the liquid in thin film form, and its forward mode of operation imposes no restriction concerning the optical properties of the substrate. These characteristics make it well suited for printing a wide variety of materials of interest in diverse applications. We demonstrate that the film-free laser forward printing technique is capable of printing microdroplets with good resolution, reproducibility and control, and analyze the influence of the main process parameter, laser pulse energy. The mechanisms of liquid printing are also investigated: timeresolved imaging provides a clear picture of the dynamics of liquid transfer which allows understanding the main features observed in the printed droplets.

show abstract

“…Laser-induced forward transfer (commonly abbreviated to LIFT) is a direct-write technique that allows the selective transfer of many materials on a micrometer scale [1][2][3][4][5], including liquids [6] and living cells [7,8]. In the LIFT process, a thin film serves as a donor material that is to be transferred, which is referred to as the donor layer, see Fig.…”

Section: Introductionmentioning

confidence: 99%

Solid-phase laser-induced forward transfer of variable shapes using a liquid-crystal spatial light modulator

et al. 2015

View full text Add to dashboard Cite

Laser-induced forward transfer is a promising method for 3D printing of various materials, including metals. The ejection mechanism is complex and depends strongly on the experimental parameters, such as laser fluence and donor layer thickness. However, the process can be categorized by the physical condition of the ejected material, i.e., the donor layer is transferred in liquid phase or the material is transferred as a 'pellet' in solid phase. Currently, solid-phase transfer faces several problems. Large shearing forces, occurring at the pellet perimeter during transfer, limit the similarity between the desired pellet shape and the deposited pellet shape. Furthermore, the deposited pellet may be surrounded by debris particles formed by undesired transferred donor material. This work introduces a novel approach for laser-induced forward transfer of variable shaped solid-phase pellets. A liquidcrystal spatial light modulator (SLM) is used to apply grayscale intensity modulation to an incident laser beam to shape the intensity profile. Optimized beams consist of a high fluence perimeter around an interior characterized by a lower fluence level. These beams are used successfully to transfer solid-phase pellets out of a 100-nm Au donor layer using a single laser pulse. The flexibility of the SLM allows a variable desired pellet shape. The shapes of the resulting deposited pellets show a high degree of similarity to the desired shapes. Debris-free deposited pellets are achieved by pre-machining the donor layer, prior to the transfer, using a double-pulse process.

show abstract

Printing biological solutions through laser-induced forward transfer

Cited by 61 publications

References 21 publications

Time-resolved imaging of the laser forward transfer of liquids

Time-resolved imaging of the laser forward transfer of liquids

Film-free laser forward printing of transparent and weakly absorbing liquids

Solid-phase laser-induced forward transfer of variable shapes using a liquid-crystal spatial light modulator

Contact Info

Product

Resources

About