Printed Nanochain‐Based Colorimetric Assay for Quantitative Virus Detection

Zhang, Zeying; Wang, Huadong; Su, Meng; Sun, Yali; Tan, Shuang‐Jie; Ponkratova, Ekaterina; Zhao, Maoxiong; Wu, Dongdong; Wang, Keyu; Pan, Qi; Chen, Bingda; Zuev, Dmitry; Song, Yanlin

doi:10.1002/ange.202109985

Cited by 13 publications

(17 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only the characteristic scattered light is collected by the objective. [ 16 ] The color changes of scattered light from nanoparticles with different shapes can be effectively observed by an optical microscope. [ 14 ] Comparing the optical images of nanoparticles modified with or without antibodies, there is no obvious change for the color of the scattered light (Figure 1c‐i,ii).…”

Section: Resultsmentioning

confidence: 99%

“…Under the oblique incidence light and narrower received angle (Objective NA is 0.4), the reflected light collected by the microscope decreases and the scattered light increases. [ 16 ] As the increasing number of silica nanoparticles, the color of scattered light gradually changes from yellow to red and finally to purple. The introduction of silica nanoparticles increases the scattering cross section of single PS nanoparticle, which makes more scattered light into the objective.…”

Section: Resultsmentioning

confidence: 99%

“…[ 15 ] However, due to the weak signal from individual nanoparticle, the volumetric changes in peak/valley shift of scatter spectra have great challenges in generating perceptible color changes for easy‐to‐use biosensors. [ 16 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Coloration Biochip for Optical Virus Detection Based on Printed Single Nanoparticle Array

Wang

Zhang

et al. 2022

Adv Materials Inter

Self Cite

View full text Add to dashboard Cite

Direct and ultrasensitive detection of nanoscale objects is of great importance for materials science and biomedical application. Here, a printed single nanoparticle array‐based coloration biochip is developed for direct visualizing nanoscale objects with the microscopy image. Arising from the scattering cross section induced Mie scattering enhancement, the color change of nanoparticles with/without viruses can be observed with a conventional optical microscope. The scattering light from single nanoparticle has the size‐dependent characteristics of wavelength and intensity variation, allowing for optically detecting nanoscale virus. By comparing optical images before and after attaching viruses, quantitative detection can be achieved with the virus concentrations from 1.0 × 102 to 1.0 × 106 PFU mL–1 and a detection limit of 1.0 × 102 PFU mL–1. The antibody‐modified array can specifically recognize influenza viruses in 15 min. The result provides a promising approach to detect diverse biological samples, including protein, exosomes, and platelet microparticle.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Coloration Biochip for Optical Virus Detection Based on Printed Single Nanoparticle Array

Wang

Zhang

et al. 2022

Adv Materials Inter

Self Cite

View full text Add to dashboard Cite

show abstract

“…A series of nanomaterial‐based biosensors were designed to get faster, more sensitive and accurate results of viral detection 107,108 . Printed polystyrene nanochains assays modified with specific antibodies could realize the colorimetric quantification of the virus just by a portable smartphone 122 . The surfaced‐enhanced Raman scattering (SERS) biosensor based on ACE2‐engineered gold nanostructures could even detect the SARS‐CoV‐2 at the single‐virus level 123 .…”

Section: Perspectives and Current Challengesmentioning

confidence: 99%

Detection, prevention and treatment of COVID‐19 and opportunities for nanobiotechnology

Bao

Yang

et al. 2022

VIEW

View full text Add to dashboard Cite

Since the outbreak of COVID‐19, the number of confirmed cases and deaths has increased globally at a dramatic speed. In view of the serious health threat to humans, this review discusses the state‐of‐the‐art studies about fighting this disease. It summarizes the current strategies and recent advances in detecting, preventing, and treating COVID‐19 and interprets the underlying mechanisms in detail. Detection of COVID‐19 can be successfully achieved by multiple techniques such as polymerase chain reaction, computed tomography imaging, and nano‐biosensing. Inactivated virus vaccine, nucleic acid vaccine, and different nanoparticles have been employed to effectively prevent COVID‐19. A variety of agents such as antiviral agents, neutralizing antibodies, and nanotherapeutics have been developed to treat COVID‐19 with exciting efficacy. Although nanobiotechnology has shown great potential in the diagnosis, prevention, and treatment of COVID‐19, efforts should be made to explore new biocompatible nano‐biomaterials to advance this field to clinical applications. Hence, nanobiotechnology paves a new way to detect, prevent, and treat COVID‐19 effectively.

show abstract

“…Several unconventional techniques have been developed for designing FETs 5–13 and other devices based on sub‐100 nm patterned nanostructures, attracting considerable attention for a broad array of applications (Figure 1). Nanostructured materials 14 and nanoconfinement 15 play important roles in the achievement of enhanced performance and novel functionalities for nanooptics, 16–22 electrics, 23–28 sensing, 29–37 and other emerging devices 38–43 …”

Section: Introductionmentioning

confidence: 99%

Advanced unconventional techniques for sub‐100 nm nanopatterning

Guo

Min

et al. 2022

InfoMat

Self Cite

View full text Add to dashboard Cite

Patterned nanostructures with ultrasmall features endow functional devices with unique nanoconfinement and performance enhancements. The increasing demand for miniaturization has stimulated the development of sub-100 nm nanopatterning techniques. Beyond conventional lithography-which is limited by unavoidable factors-advanced patterning techniques have been reported to produce nanoscale features down to molecular or even atomic scale. In this review, unconventional techniques for sub-100 nm nanopatterning are discussed, in particular the principles by which to achieve the desired patterns (among other important issues). Such techniques can be classified into three categories: template-replica, template-induced, and template-free techniques. Moreover, multi-dimensional nanostructures consist of various building materials, the unique properties of which are summarized. Finally, the remaining challenges and opportunities for large-scale patterning, the improvement of device performance, the multi-dimensional nanostructures of biocompatible materials, molecular-scale patterning, and the carbon footprint requirements for future nanofabrication processes are discussed.

show abstract

Printed Nanochain‐Based Colorimetric Assay for Quantitative Virus Detection

Cited by 13 publications

References 59 publications

A Coloration Biochip for Optical Virus Detection Based on Printed Single Nanoparticle Array

A Coloration Biochip for Optical Virus Detection Based on Printed Single Nanoparticle Array

Detection, prevention and treatment of COVID‐19 and opportunities for nanobiotechnology

Advanced unconventional techniques for sub‐100 nm nanopatterning

Contact Info

Product

Resources

About