An offset-fed ISM/Ultra-wideband (UWB) antenna with a slotted ground plane designed for on-body communications is presented in this paper. The antenna consists of a radiator very close to a square shape, a feed line slightly offset from the middle along the radiator side and three rectangular slots at the top edge of the ground plane. The offset feed line is used to improve the radiation pattern for on-body communications and the slots on the ground plane are used to improve impedance matching of the antenna. The antenna is studied using computer simulation. For verification of simulation results, the antenna is fabricated and measured. Simulated and measured results show good agreements in terms of reflection coefficient, gain, efficiency and radiation pattern. Measured results show that the antenna can achieve a wide bandwidth from 2.38 to 14.5 GHz with more omnidirectional radiation patterns in the E-plane than conventional monopole, making it a potential candidate for on-body communications using UWB.