Printable Resin Modified by Grafted Silver Nanoparticles for Preparation of Antifouling Microstructures with Antibacterial Effect

Abstract

The usage of three-dimensional (3D) printed materials in many bioapplications has been one of the fastest-growing sectors in the nanobiomaterial industry in the last couple of years. In this work, we present a chemical approach for grafting silver nanoparticles (AgNPs) into a resin matrix, which is convenient for 3D printing. In this way, the samples can be prepared and are able to release silver ions (Ag+) with excellent antibacterial effect against bacterial strains of E. coli and S. epidermidis. By the proposed process, the AgNPs are perfectly mixed and involved in the polymerization process and their distribution in the matrix is homogenous. It was also demonstrated that this approach does not affect the printing resolution and the resin is therefore suitable for the construction of microstructures enabling controlled silver ion release and antifouling properties. At the same time the physical properties of the material, such as viscosity and elasticity modulus are preserved. The described approach can be used for the fabrication of facile, low-cost 3D printed resin with antifouling-antibacterial properties with the possibility to control the release of Ag+ through microstructuring.

A Review on Antibacterial Biomaterials in Biomedical Applications: From Materials Perspective to Bioinks Design

“…Hence, encapsulating antibacterial agents into the biomaterial matrix has attained much consideration in the past few years [ 147 ]. Antibacterial biomaterials are comparatively capable of repelling bacterial cells, inhibiting their adhesion, or inactivating/destroying cells attached to the surface, while not sufficiently productive in destroying the pathogens due to the complicated mechanisms of bacteria [ 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ]. Thus, developing highly effective and specifically targeted biomaterials that generate antimicrobial agents and their service in 3D printing inks is vital for TE applications.…”

Polymer–Metal Bilayer with Alkoxy Groups for Antibacterial Improvement

“…Today, new polymers are continually being produced with better characteristics including outstanding and tissue-like mechanical properties [ 9 , 10 ] and excellent biocompatibility [ 11 , 12 ]. Their high plasticity (shaping as demanded) arises from the preparation methods, such as heat-driven polymerization [ 13 ] or usage of three-dimensional printers [ 14 ], by which the monomer is put into the meld of a desired shape before its polymerization.…”