Printable hyaluronic acid hydrogel functionalized with yeast-derived peptide for skin wound healing

Ghaffari-Bohlouli, Pejman; Simińska-Stanny, Julia; Jafari, Hafez; Mirzaei, Mahta; Delporte, Christine; Shavandi, Amin

doi:10.1016/j.ijbiomac.2023.123348

Cited by 17 publications

(7 citation statements)

References 65 publications

(88 reference statements)

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“…One interconnected pore was utilized to calculate the values for the printability and spreading rate of the bioink. The formula below was used to calculate the printability , Pr ⁡ = L 2 16 A where L denotes perimeter, and A is area. For the ideal/perfect square, the printability should be 1 (Pr = 1).…”

Section: Methodsmentioning

confidence: 99%

Biomimetic Mineralization of Mn-Doped Biphasic Calcium Phosphate in the GelMa Hydrogel Acting as a Functional 3D Bioscaffold for Osteo Defect Repair

Kamaraj,

Datla,

Moulton

et al. 2023

ACS Appl. Polym. Mater.

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Multicomponent composite scaffolds are stimulating biomaterials that contribute to enhanced physical and mechanical properties and are able to induce or enhance cell differentiation toward specific lineages depending upon their composition. In the case of bone tissue engineering, ceramic components act as "osteoinductive", which, when incorporated into a polymer system, helps encapsulated cells undergo osteodifferentiation. However, formulating a tissue-personalized bioink to provide an appropriate cell niche is challenging. The reproducibility of the bioink and its in vitro characterization are crucial for a scaffold. Here, we show that the composite scaffold drives the human umbilical cord mesenchymal stem cells (hUMSCs) into osteogenic lineage without the addition of any growth factors. Our findings demonstrate that incorporation of Mn-doped BCP into the hydrogel system consisting of gelatin methacrylate and sodium alginate improved the printability and mechanical strength of the scaffold. The possible mechanism behind the enhancement in physical and mechanical properties of bioink is intermolecular ionic interaction and hydrogen bonding between the polymer and bioceramic. Biological results indicate that the composite scaffolds are biocompatible and support cell proliferation during the course of cell culture. Furthermore, RT-qPCR, alkaline phosphate, and alizarin red staining were also used to assess the differentiation ability of cells. The results show that Mn-doped BCP significantly accelerated the osteogenic differentiation of hUMSCs encapsulated within the composite scaffolds. Overall, these results validate the use of Mn-doped BCP bioink for osteo defect regeneration in vitro and provide intriguing opportunities for mineralized bone scaffolds to advance in bone tissue engineering using 3D bioprinting.

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Section: Methodsmentioning

confidence: 99%

Biomimetic Mineralization of Mn-Doped Biphasic Calcium Phosphate in the GelMa Hydrogel Acting as a Functional 3D Bioscaffold for Osteo Defect Repair

Kamaraj,

Datla,

Moulton

et al. 2023

ACS Appl. Polym. Mater.

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“…Antibacterial nanoparticles could prevent the growth of bacteria and fungus by direct contact, disrupting their normal metabolism and adversely altering the membranes of the microorganisms. 134 Recently, experts have concentrated on the applications of antibacterial nanoparticles like zinc oxide (ZnO), copper, and silver (Ag) in biomedical fields. 144 Ag nanoparticles, because of their broad-spectrum antibacterial action, affordability, and low toxicity, are most frequently researched for wound treatments.…”

Section: Antibacterial Propertymentioning

confidence: 99%

“…8b. 134 Another typical HA-based photocrosslinked hydrogel is methacrylated hyaluronic acid (MeHA). For example, Zhao's team successfully used the molding method to fabricate Zn-MOF encapsulated MeHA microneedles.…”

Section: Animal Tissue-derived Biomaterialsmentioning

confidence: 99%

Animal tissue-derived biomaterials for promoting wound healing

Cao

Lin

et al. 2023

Mater. Horiz.

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“…It is, therefore, crucial to synthesize functional wound dressings which promote wound healing while having innate antibacterial properties. To this regard, various biomaterials, such as foams [27,28], films [29,30], nanosheets [31], and hydrogels [10, [32][33][34][35][36][37][38] have been developed. In this strategy, the hydrogels with the injectable and antibacterial properties were considered as the most promising biomaterial because of their tunable excellent antibacterial and self-healing properties, which will serve to enhance the overall efficiency of wound healing.…”

Section: Introductionmentioning

confidence: 99%

Facile preparation of self-healing hydrogels based on chitosan and PVA with the incorporation of curcumin-loaded micelles for wound dressings

Ding,

et al. 2024

Biomed. Mater.

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The increased demand for improved strategies for wound healing has, in recent years, motivated the development of multifunctional hydrogels with favorable bio-compatibility and antibacterial properties. To this regard, the current study presented the design of a novel self-healing composite hydrogel that could perform as wound dressing for the promotion of wound healing. The composite hydrogels were composed of polyvinyl alcohol (PVA), borax and chitosan functionalized with sialic acid (SA-CS) and curcumin loaded Pluronic F127 micelles. The hydrogels were formed through the boronic ester bond formation between PVA, SA-CS and borax under physiological conditions and demonstrated adjustable mechanical properties, gelation kinetics and antibacterial properties. When incubating with NIH3T3 cells, the hydrogels also demonstrated good biocompatibility. These aspects offer a promising foundation for their prospective applications in developing clinical materials for wound healing.

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Printable hyaluronic acid hydrogel functionalized with yeast-derived peptide for skin wound healing

Cited by 17 publications

References 65 publications

Biomimetic Mineralization of Mn-Doped Biphasic Calcium Phosphate in the GelMa Hydrogel Acting as a Functional 3D Bioscaffold for Osteo Defect Repair

Biomimetic Mineralization of Mn-Doped Biphasic Calcium Phosphate in the GelMa Hydrogel Acting as a Functional 3D Bioscaffold for Osteo Defect Repair

Animal tissue-derived biomaterials for promoting wound healing

Facile preparation of self-healing hydrogels based on chitosan and PVA with the incorporation of curcumin-loaded micelles for wound dressings

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