Printability Study of Bioprinted Tubular Structures Using Liquid Hydrogel Precursors in a Support Bath

Ding, Houzhu; Chang, Robert C.

doi:10.3390/app8030403

Cited by 82 publications

(60 citation statements)

References 26 publications

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“…Furthermore, nanoclay possess thermal stability, transparency (for photo-polymerization), and ionic insensitivity compared to common sacrificial support baths, such as surfactants and poloxamer. [198] Nanoclay support baths can assist printing of various materials or composites (e.g. salts).…”

Section: D Printing With Hydrogels: Sacrificial Support Bathmentioning

confidence: 99%

2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

et al. 2019

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Clay nanomaterials are an emerging class of two-dimensional (2D) biomaterials of interest due to their atomically thin layered structure, discotic charged characteristics and well-defined composition. Synthetic nanoclays are plate-like polyions composed of simple or complex salts of silicic acids with a heterogeneous charge distribution and patchy interactions. Due to their biocompatible characteristics, unique shape, high surface-to-volume ratio and charge distribution, nanoclays are investigated for various biomedical applications. This review article will provide a critical overview of the physical, chemical and physiological interactions of nanoclays with biological moieties including cells, proteins and polymers. The state-of-the-art biomedical applications of 2D nanoclay in regenerative medicine, therapeutic delivery and additive manufacturing are reviewed. In addition, recent developments that are shaping this emerging field are discussed and promising new research directions for 2D nanoclay-based biomaterials are identified.

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Section: D Printing With Hydrogels: Sacrificial Support Bathmentioning

confidence: 99%

2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

et al. 2019

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“…Alginate can be printed effectively at a range of temperatures in order to achieve the required viscosity (He et al, 2016;Zhu et al, 2018). However, alginatebased hydrogels have been shown to be most effective at 37 • C due to: accurate extrusion flow rate, decreased occurrence of obstruction and compatibility with cell viability (Ding et al, 2018). One study showed that for a 7% alginate/8% gelatin hydrogel, optimum printing parameters at 37 • C are as follows: nozzle gauge = 30 G, printing pressure = 100 kPa, and printing speed = 4 mm/s (Webb and Doyle, 2017).…”

Section: Plant-derived Biomaterials Alginatementioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

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“…Hydrogels The printability can influence other interrelated factors, such as the morphology and mechanical properties of scaffolds. Consequently, it can affect cell response [5], and it is well-accepted that the mechanical properties of scaffolds can influence cell faith [6]. Hence, it is important to study elements that can influence printability.…”

Section: Introductionmentioning

confidence: 99%

Printability of 3D Printed Hydrogel Scaffolds: Influence of Hydrogel Composition and Printing Parameters

et al. 2019

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Extrusion-based bioprinting of hydrogel scaffolds is challenging due to printing-related issues, such as the lack of capability to precisely print or deposit hydrogels onto three-dimensional (3D) scaffolds as designed. Printability is an index to measure the difference between the designed and fabricated scaffold in the printing process, which, however, is still under-explored. While studies have been reported on printing hydrogel scaffolds from one or more hydrogels, there is limited knowledge on the printability of hydrogels and their printing processes. This paper presented our study on the printability of 3D printed hydrogel scaffolds, with a focus on identifying the influence of hydrogel composition and printing parameters/conditions on printability. Using the hydrogels synthesized from pure alginate or alginate with gelatin and methyl-cellulose, we examined their flow behavior and mechanical properties, as well as their influence on printability. To characterize the printability, we examined the pore size, strand diameter, and other dimensions of the printed scaffolds. We then evaluated the printability in terms of pore/strand/angular/printability and irregularity. Our results revealed that the printability could be affected by a number of factors and among them, the most important were those related to the hydrogel composition and printing parameters. This study also presented a framework to evaluate alginate hydrogel printability in a systematic manner, which can be adopted and used in the studies of other hydrogels for bioprinting.

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Printability Study of Bioprinted Tubular Structures Using Liquid Hydrogel Precursors in a Support Bath

Abstract: Bioprinting of complex cell-laden tissue constructs that mimic the human vascular tissue structure.

Cited by 82 publications

References 26 publications

2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Printability of 3D Printed Hydrogel Scaffolds: Influence of Hydrogel Composition and Printing Parameters

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