PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas

Kopczyńska, Magda; Kolenda, Tomasz; Guglas, Kacper; Sobocińska, Joanna; Teresiak, Anna; Bliźniak, Renata; Maćkiewicz, Andrzej; Mackiewicz, Jacek; Lamperska, Katarzyna

doi:10.3390/diagnostics10100762

Cited by 23 publications

(26 citation statements)

References 45 publications

(57 reference statements)

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“…However, the function of different lincRNAs is not fully understood. In the case of lncRNAs, our results indicated the role of lncRNA EGOT, PRINS, and CDKN2B-AS1 (ANRIL) [164,165]. Moreover, in our published work, we observed changes in lincRNAs including up-regulation of TTTY14, and TTTY15, and down-regulation of MEG3 and H19 in HPV(+) patients in comparison to HPV(−).…”

Section: Lincrnas In Hpv-positive Hnsccsupporting

confidence: 66%

“…We also observed that TTY14, TTY15, and MEG3 showed the high discrimination potential of HPV(−) and HPV(+) patients. However, no differences in the case of MALAT1 and CYTOR (LINC00152) depending on the HPV status based on TCGA data were noticed [165]. Tomar et al study based on HNSCC samples indicated changes of TTTY14, TTTY15, XIST, and CYTOR (LINC00152) depending on the HPV infection and activity status [166].…”

Section: Lincrnas In Hpv-positive Hnsccmentioning

confidence: 96%

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Long Intergenic Non-Coding RNAs in HNSCC: From “Junk DNA” to Important Prognostic Factor

Kozłowska

Kolenda

Poter

et al. 2021

Cancers

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Head and neck squamous cell carcinoma is one of the most common and fatal cancers worldwide. Even a multimodal approach consisting of standard chemo- and radiotherapy along with surgical resection is only effective in approximately 50% of the cases. The rest of the patients develop a relapse of the disease and acquire resistance to treatment. Especially this group of individuals needs novel, personalized, targeted therapy. The first step to discovering such solutions is to investigate the tumor microenvironment, thus understanding the role and mechanism of the function of coding and non-coding sequences of the human genome. In recent years, RNA molecules gained great interest when the complex character of their impact on our biology allowed them to come out of the shadows of the “junk DNA” label. Furthermore, long non-coding RNAs (lncRNA), specifically the intergenic subgroup (lincRNA), are one of the most aberrantly expressed in several malignancies, which makes them particularly promising future diagnostic biomarkers and therapeutic targets. This review contains characteristics of known and validated lincRNAs in HNSCC, such as XIST, MALAT, HOTAIR, HOTTIP, lincRNA-p21, LINC02487, LINC02195, LINC00668, LINC00519, LINC00511, LINC00460, LINC00312, and LINC00052, with a description of their prognostic abilities. Even though much work remains to be done, lincRNAs are important factors in cancer biology that will become valuable biomarkers of tumor stage, outcome prognosis, and contribution to personalized medicine.

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Section: Lincrnas In Hpv-positive Hnsccsupporting

confidence: 66%

Section: Lincrnas In Hpv-positive Hnsccmentioning

confidence: 96%

Long Intergenic Non-Coding RNAs in HNSCC: From “Junk DNA” to Important Prognostic Factor

Kozłowska

Kolenda

Poter

et al. 2021

Cancers

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“…These findings were consistent with our understanding that the three lncRNAs were associated with the prognosis of cancer. Moreover, previous study suggested that TTTY15 was associated with HPV infection, and which was upregulated in HPV-positive patients ( 41 ). Previous studies reported that Beclin 1 (BECN1) and LC3 are unique autophagy-related protein ( 42 ).…”

Section: Discussionmentioning

confidence: 94%

Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature

et al. 2021

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Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis. Considerable evidence indicates that autophagy and non-coding RNA play essential roles in the biological processes involved in cancers, but associations between autophagy-related long non-coding RNAs (lncRNAs) and HNSCC remain unclear. In the present study, HNSCC RNA sequences and autophagy-related gene data were extracted from The Cancer Genome Atlas database and the Human Autophagy Database. A total of 1,153 autophagy-related lncRNAs were selected via calculating Pearson’s correlation coefficient. Three prognosis-related autophagy lncRNAs were identified via univariate Cox regression, least absolute shrinkage and selection operator analysis, and multivariate Cox regression analysis. We also constructed a prognostic model based on these autophagy-related lncRNAs and evaluated its ability to accurately and independently predict the prognosis of HNSCC patients. The area under the curve (AUC) was 0.864 (3-year) and 0.836 (5-year), and our model can independently predict the prognosis of HNSCC. The prognostic value of the three autophagy lncRNAs was confirmed via analysis of samples from five databases. To further identify the functions of the three lncRNAs, a co-expression network was constructed and pathway analysis was performed. In that analysis the lncRNAs were correlated with 189 related genes and 20 autophagy-related genes, and these lncRNAs mainly involved homologous recombination, the Fanconi anemia pathway, the autophagy-related pathway, and immune-related pathways. In addition, we validated the expression levels of three lncRNAs and autophagy markers (ATG12, BECN1, and MAP1LC3B) based on TIMER, Oncomine, and HPA database analysis. Our results indicated that TTTY15 was increased in HPV positive and HPV negative HNSCC patients, and three autophagy markers were up-regulated in all HNSCCC patients. Lastly, association between three lncRNAs and autophagy markers was performed, and our results showed that TTTY15 and MIF-AS1 were associated with autophagy markers. Collectively, these results suggested that three autophagy-related lncRNAs have prognostic value in HNSCC patients.

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“…of note, abnormal lncrnas have been reported to be associated with HPV infection in cancers, including cc. For instance, lncrna psoriasis-susceptibility-related rna gene induced by stress (PrinS) has been indicated to be markedly higher in HPV+ patients with head and neck squamous cell carcinoma (HnScc) than that in HPV-patients with HnScc, and the expression of PrinS was significantly related to HPV-infected HnScc (25). Zhou et al (26) reported that lncrna oncogene-induced senescence 1 (lncrna-oiS1) is decreased in HPV+ patients with cervical squamous cell carcinoma (cScc) and HPV+ Hr, hazard ratio; HPV, human papillomavirus; BMi, body mass index; FiGo, international Federation of Gynecology and obstetrics; dleu1, long noncoding rna deleted in lymphocytic leukemia 1. cScc cells and may enhance the proliferation of HPV+ cScc cells.…”

Section: Discussionmentioning

confidence: 99%

Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer

Dong

Wang

et al. 2022

Mol Med Rep

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Human papillomavirus (HPV) is the most common risk factor for the occurrence of cervical cancer (cc). in recent years, the important roles of long non-coding rnas (lncrnas) in cc have emerged, but studies on the relationship between lncrnas and HPV-positive (HPV+) cc remain scarce. The present study aimed to investigate whether lncrna deleted in lymphocytic leukemia 1 (dleu1) is associated with HPV infection and explore the clinical significance of DLEU1 in HPV+ patients with cc. dleu1 expression was detected by reverse transcription-quantitative Pcr. The ability of dleu1 to screen patients with cc from controls and differentiate individuals with different HPV infection status was evaluated by receiver operating characteristic analysis. The association of dleu1 with the survival prognosis of patients with cc was assessed by Kaplan-Meier survival analysis and cox regression analysis. The rna interactome database was used to predict molecules interacting with dleu1. The results indicated that DLEU1 expression was significantly upregulated in CC tissues and cell lines, particularly in those that were HPV+. in addition, dleu1 had a high diagnostic value in discriminating patients with cc and differentiating between HPV+ and HPV-patients with cc, and had a certain ability to screen HPV+ controls. dleu1 was correlated with HPV infection in cc patients. Furthermore, dleu1 was indicated to be associated with survival prognosis in both total patients with cc and HPV+ patients with cc, and independently predict the prognosis of patients with cc. Most of the molecules interacting with dleu1 were micrornas. in conclusion, abnormal dleu1 expression is associated with HPV infection and may serve as a diagnostic and prognostic biomarker for HPV+ patients with cc.

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PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas

Cited by 23 publications

References 45 publications

Long Intergenic Non-Coding RNAs in HNSCC: From “Junk DNA” to Important Prognostic Factor

Long Intergenic Non-Coding RNAs in HNSCC: From “Junk DNA” to Important Prognostic Factor

Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature

Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer

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