Principles of Radiation Oncology

Kinsella, Timothy J.; Sohn, Jason W.; Wessels, Barry W.

doi:10.1007/0-387-31056-8_3

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…Radiotherapy (irradiating the tumour with high energy photons or particles) is an important therapeutic strategy [2]. Developments in radiotherapy treatments have brought solutions that allow a more precise delivery of a higher dose to the tumour with less side effects to healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound based dosimetry for radiotherapy: In-vitro proof of principle

Verboven

D’Agostino

Callens

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Advances in radiotherapeutic treatments and the ability to detect accidents due to equipment mishandling or malfunctioning require the development of on-line in-vivo dosimetry systems. Here, we propose to use ultrasound contrast agents (UCAs) as a possible candidate for such a system, based on the hypothesis that irradiation of UCAs will modify their viscoelastic and/or their geometric properties and consequently their ultrasonic response. The aim of this study is to provide a proof of principle in-vitro. Solutions of saline with several commercially available lipid-shelled UCAs were investigated and the agents were characterized using a through transmission set-up, before and after irradiation. Although the agents were not yet optimized for radiation sensitivity, Targestar-P showed a noticeable dose dependency of the magnitude of the jump in phase velocity and amplitude of the attenuation at resonance. These results confirm the hypothesis that the ultrasonic readout of UCAs can be correlated with the ionizing radiation dose delivered to the agents. This supports the concept of using ultrasound and UCAs as a potential tool for in-vivo dosimetry.

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Section: Introductionmentioning

confidence: 99%

Ultrasound based dosimetry for radiotherapy: In-vitro proof of principle

Verboven

D’Agostino

Callens

et al. 2014

2014 IEEE International Ultrasonics Symposium

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“…This primarily curative treatment can be combined with other forms of treatment such as surgery and chemotherapy. 2 The benefits of radiation therapy are a reduced likelihood of recurrence and a better chance of survival. [3][4][5][6] However, radiation therapy also has risks and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Respiratory gating in patients with lung carcinoma undergoing radiotherapy

et al. 2021

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Aim: This study aims to compare the gating signals of patients with lung cancer recorded during the planning computed tomography scan with the ones recorded during treatment fractions. The results provide insights into how representative the respiratory signals from the planning scan are for radiation dose partitioning. Materials and methods: The amplitude and frequency of the respiratory signals of 29 patients with lung carcinoma were analysed and compared with the amplitude and frequency of those recorded during their planning scans. Moreover, a cross-correlation analysis was performed between the difference between the planning scan and fractions and features from the planning scan. Results: Two patients showed significantly different amplitude and frequency during treatment fractions compared to those from the planning scan. These patients showed low variances in frequency and amplitude during the different fractions. The difference between planning scan and fractions is correlated with the variances within the planning scan. Findings: Respiratory signals can differ between the planning scan and the fractions. In this case, a new planning scan may be beneficial. The respiratory signals from the planning scan may be predictive of whether the planning scan will be representative and usable as a control measure during radiotherapy fractions.

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Unravelling the Genomic Targets of Small Molecules and Application of CRISPR-Cas 9 System for Genomic Editing in Cancer with Respective Clinical Applications

Tariq

2020

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

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Principles of Radiation Oncology

Cited by 4 publications

References 64 publications

Ultrasound based dosimetry for radiotherapy: In-vitro proof of principle

Ultrasound based dosimetry for radiotherapy: In-vitro proof of principle

Respiratory gating in patients with lung carcinoma undergoing radiotherapy

Unravelling the Genomic Targets of Small Molecules and Application of CRISPR-Cas 9 System for Genomic Editing in Cancer with Respective Clinical Applications

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