Principles of pharmacological research of nutraceuticals

Andrew, Ruth; Izzo, Angelo A.

doi:10.1111/bph.13779

Cited by 135 publications

(118 citation statements)

References 155 publications

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“…Coumarins are known for their anticoagulant effects. The observation of fatal hemorrhage in cattle eating mouldy sweet clover, as a result of impaired coagulation, led to the introduction in therapy of the anticoagulant drug dicoumarol, which is chemically related to warfarin (Andrew & Izzo, ). A Norwegian study has recently shown that children eating oatmeal porridge several times a week sprinkled with cinnamon could have a coumarin intake greatly exceeding the tolerable daily intake (Fotland, Paulsen, Sanner, Alexander, & Husøy, ).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

“…Within nutraceuticals (Andrew & Izzo, ; Daliu, Santini, & Novellino, ; Durazzo & Lucarini, ; Santini et al, ; Santini & Novellino, ; Santini & Novellino, ; Santini, Tenore, & Novellino, ), more than 8,000 different phenolics are identified in the plant kingdom and represent one of most numerous and widely distributed class of plant secondary metabolites (Cheynier, Comte, Davies, Lattanzio, & Martens, ; Kabera, Semana, Mussa, & He, ; Santini, Novellino, Armini, & Ritieni, ). Several outstanding reviews on polyphenols have been recently published (Amiot, Riva, & Vinet, ; Bernatoniene & Kopustinskiene, ; Białecka‐Florjańczyk, Fabiszewska, & Zieniuk, ; Clifford, Jaganath, Ludwig, & Crozier, ; Costa et al, ; Durazzo et al, ; Pervaiz, Songtao, Faghihi, Haider, & Fang, ; Roche et al, ; Xiao, Zhang, Tong, & Shi, ; H. Zhang & Tsao, ; Zhao et al, ), and the reader is referred to them for a more in‐depth information.…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

578

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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Section: Phenolic Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

578

397

View full text Add to dashboard Cite

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“…The requirement of a strict quality control program (physical–chemical and microbiological analyses) has to include the whole manufacturing process from the cultivation, plant collection, drying and storage, extract preparation, to the production, and packaging of the final product. In addition, herbal preparations may present with both pharmacokinetic and pharmacodynamics interactions if taken in conjunction with other over‐the‐counter or prescription drugs (Andrew & Izzo, ; Cordell & Colvard, ; Gohil & Patel, ; Izzo et al, ; Mohamed et al, ; J. Zhang et al, ). Some of these interactions are not well studied to date and hence make healthcare providers reluctant to recommend dietary supplements in general.…”

Section: Specific Considerations For the Use Of Herbal Medicines Durimentioning

confidence: 99%

“…Women often use herbal dietary supplements and herbal medicines during pregnancy, typically based on the belief that the use of such products is safe (Eisenberg et al, ; Fakeye, Adisa, & Musa, ; Hall, Griffiths, & McKenna, ; Hall, Griffiths, & McKenna, ; Kennedy, Lupattelli, Koren, & Nordeng, ; World Health Organization [WHO], ). Herbal medicines have been defined by the World Health as “any medicinal product based on herbs, herbal materials, herbal preparations and finished herbal products that contain as active ingredients parts of plants, other plant materials, or combinations thereof” (Andrew & Izzo, ; WHO, ). According to a study done in Nigeria (Fakeye et al, ), where the use of herbal medicines in women's health is very common, the reasons and beliefs are diverse, but among them are the following: medicinal plants have better efficacy than pharmaceutical drugs (22.4%); herbal medicines are natural and therefore viewed as safer than conventional drugs during pregnancy (21.1%); low effectiveness of conventional medicines (19.7%); the easy access to herbal medicines (11.2%); the traditional and cultural belief that herbal medicines can heal many diseases (12.5%); and comparatively, the low cost of herbal medicines (5.9%).…”

Section: Introductionmentioning

confidence: 99%

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Bruno

Simões

et al. 2018

Phytotherapy Research

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The indiscriminate use of herbal medicines to prevent or to heal diseases or even the use for questionable purposes such as weight loss has received both interest and scrutiny from the scientific community and general public alike. An increasing number of women put their own and the unborn child's health at risk due to a lack of knowledge about the phytochemical properties and adequate use of herbal medicine (phytomedicines or herbal supplements) and lack of communication with their healthcare provider. The purpose of this narrative review was to summarize the use of herbal medicines during pregnancy and their potential toxic effects to highlight the importance of caution when prescribing herbal medicines or supplements for women, because, in addition to suffering interactions and a great amount of information obtained in preclinical predictive studies, assessment of nephrotoxicity, neurotoxicity, hepatotoxicity, genotoxicity, and teratogenicity of traditional medicinal herbs still remains scarce in the clinical setting.

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“…The rising rates of obesity in the world, the limited success of lifestyle changes, and pharmacotherapy—associated to the lack of compliance of the pharmacological treatment—drive many people towards the use of products invariably defined as nutraceuticals, dietary supplements, or herbal medicinal products (Andrew & Izzo, ; Farrington, Musgrave, & Byard, ; Ríos‐Hoyo & Gutiérrez‐Salmeán, ). The popularity of such treatments for weight management has increased in the last years, and a wide variety of these products are available over the counter (Ríos‐Hoyo & Gutiérrez‐Salmeán, ).…”

mentioning

confidence: 99%