2013
DOI: 10.1111/nyas.12084
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Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit

Abstract: Renshaw cells provide a convenient model to study spinal circuit development during the emergence of motor behaviors with the goal of capturing principles of interneuron specification and circuit construction. This work is facilitated by a long history of research that generated essential knowledge about the characteristics that define Renshaw cells and the recurrent inhibitory circuit they form with motoneurons. In this review, we summarize recent data on the specification of Renshaw cells and their connectio… Show more

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Cited by 41 publications
(38 citation statements)
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“…In fact, asymmetry with regard to this branch point is not unique to intercostal segments: 3/5 of the cells reported by Lagerbäck and Kellerth (1985a) were without a caudal axonal branch, and Alvarez et al. () noted that the caudal branch of the axon appeared later in development than the rostral branch. Finally, note the differences in diameter in the rostral and caudal branches for the axons illustrated in Figure .…”
Section: Discussionmentioning
confidence: 98%
“…In fact, asymmetry with regard to this branch point is not unique to intercostal segments: 3/5 of the cells reported by Lagerbäck and Kellerth (1985a) were without a caudal axonal branch, and Alvarez et al. () noted that the caudal branch of the axon appeared later in development than the rostral branch. Finally, note the differences in diameter in the rostral and caudal branches for the axons illustrated in Figure .…”
Section: Discussionmentioning
confidence: 98%
“…At the spinal and brain stem levels, glycinergic interneurons regulate the generation of action potentials on motoneurons through the presynaptic release of glycine and subsequent GlyR activation [22]. These spinal interneurons also control reciprocal inhibition in reflex circuits producing relaxation of antagonistic muscles during the coordinated contraction of agonist muscles, where Renshaw cells regulate motoneuron excitability by recurrent inhibition through a negative feedback loop [23]. …”
Section: Glycinergic Neurotransmissionmentioning
confidence: 99%
“…In mature neurons, the activation of GlyR leads to a fast increase in the passive diffusion of anions, mainly chloride ions, into the neurons, resulting in membrane hyperpolarization and reduction in neuronal excitability (Lester et al, 2004;Miller and Smart, 2010;Zeilhofer et al, 2012). It is well accepted that inhibitory GlyR function is critical for the control of several physiologic processes, namely muscle tone, motor coordination, sensory processing, respiratory rhythms, and pain (Lynch, 2009;Callister and Graham, 2010;Zeilhofer et al, 2012;Alvarez et al, 2013). In addition, the critical role of GlyR inhibition in normal physiology is further highlighted by genetic studies in humans that have linked mutations in GlyR genes with hyperekplexia (Harvey et al, 2008).…”
Section: Introductionmentioning
confidence: 99%