Principles of analytical calibration/quantification for the separation sciences

Cuadros-Rodrı́guez, Luis; Bagur-González, M. Gracia; Sánchez-Viñas, Mercedes; González‐Casado, Antonio; Gómez-Sáez, Antonio M.

doi:10.1016/j.chroma.2007.03.030

Cited by 165 publications

(82 citation statements)

References 24 publications

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“…However, the tolerance intervals are narrower and better centered around the 0% of total error line when the internal standard is used: it reduces the total error of the measurement and improves the performance of the analytical procedure. These results confirm the observations of Demeestere et al, Su et al, and Cuadros-Rodriguez et al [38][39][40]. Therefore, the internal standard was used for routine analysis.…”

Section: Accuracy Profilesupporting

confidence: 80%

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Development and validation by accuracy profile of a method for the analysis of monoterpenes in indoor air by active sampling and thermal desorption-gas chromatography-mass spectrometry

Marlet

Lognay

2010

Talanta

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The technique of thermal desorption (TD)-GC/MS was evaluated for the measurement of monoterpenes in indoor air. The validation strategy was intentionally oriented towards routine use and the reliability of the method rather than extreme performance. For this reason, validation by accuracy profile was chosen. The accuracy profile procedure, which is based on the concept of total error (bias + standard deviation), guarantees that a known proportion of future results obtained with the method will be within acceptance limits. For all the compounds tested in the present study, α-pinene, α-terpineol, β-pinene, d-limonene, ∆ 3 -carene, camphene, 1,8-cineole, p-cymene, linalool, but not in the case of carvone, the accuracy profile procedure established that at least 95% of the future results obtained would be within the ±15% acceptance limits of the validated method over the whole defined concentration range. Other parameters, such as selectivity, recovery, repeatability, stability of the molecules of interest and the effect of temperature, were also determined. The performance of the described method was finally evaluated by the analysis of indoor air from new timber frame constructions.

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Section: Accuracy Profilesupporting

confidence: 80%

“…Quantification of field samples was conducted by the internal standard mode, as suggested by several authors, in order to compensate for measurement uncertainties during analysis [38][39][40]. n-Butyl-benzene was chosen as the internal standard for monoterpene analysis [30].…”

Section: Td-gc-ms Analysismentioning

confidence: 99%

Development and validation by accuracy profile of a method for the analysis of monoterpenes in indoor air by active sampling and thermal desorption-gas chromatography-mass spectrometry

Marlet

Lognay

2010

Talanta

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“…EC is adequate for analytical procedures that could be considered as methods free from matrix effects, but it has the main limitation coming from the assumption that the different environments (matrices) of the calibration standards (solvent, buffer,…) and of the samples are equivalent, and they have no effect on the calibration function [21]. If this assumption is incorrect, additive and/or proportional systematic errors may appear.…”

Section: The External Calibrationmentioning

confidence: 99%

“…It is named so because the calibration standards are not made up of the sample test portion. Instead, they are prepared and analysed separately from samples [21]. Accordingly, the signals recorded accounts for the analyte added as primary standard, reagents, solvents and other agents according to the analytical procedure, except the sample matrix.…”

Section: The External Calibrationmentioning

confidence: 99%

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Practical Considerations on Indirect Calibration in Analytical Chemistry

González¹

2017

Uncertainty Quantification and Model Calibration

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Indirect or methodological calibration in chemical analysis is outlined. The establishment of calibration curves is introduced and discussed. Linear calibration is presented and considered in three scenarios commonly faced in chemical analysis: external calibration (EC) when there are no matrix effects in the sample analysis; standard addition calibration (SAC) when these effects are present and internal standard calibration (ISC) in cases of intrinsic variability of the analytical signal or possible losses of the analyte in stages prior to the measurement. In each kind of calibration, the uncertainty and confidence interval for the determined analyte concentration are given.

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Evolution of the Quality Concept in Analytical Laboratories

Cuadros-Rodrı́guez

González‐Casado

Ruíz-Samblás

et al. 2017

Encyclopedia of Analytical Chemistry

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The formal recognition of quality in the laboratory context dates from the end of the twentieth century, when the first written standards, outlining specific quality requirements, were published. Since then, and for almost 30 years, the concept of quality related to the activity of analytical laboratories has evolved significantly. It has also currently diversified according to the specific laboratory work scenario and the type and intended use of the results. This evolution is particularly noticeable in pharmaceutical laboratories that carry out quality control of drugs and medical devices. With regard to this specific subject, these laboratories are undoubtedly a step ahead of analytical laboratories that operate in other essential fields, such as food safety or environmental monitoring. This article provides an overview of analytical laboratories' concern with quality requirements that is objective although not entirely devoid of criticism. The article has been structured into sections, adopting a top‐down approach (from general to specific issues): laboratory, instruments and equipment, methods and procedures, and results. Two annexes are included: the first one summarizes the evolution of the main written standards (ISO 9001, ISO 17025 and GLP), while the second annex provides a comprehensive list of current technical standards and directives related to analytical quality laboratories.

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Principles of analytical calibration/quantification for the separation sciences

Cited by 165 publications

References 24 publications

Development and validation by accuracy profile of a method for the analysis of monoterpenes in indoor air by active sampling and thermal desorption-gas chromatography-mass spectrometry

Development and validation by accuracy profile of a method for the analysis of monoterpenes in indoor air by active sampling and thermal desorption-gas chromatography-mass spectrometry

Practical Considerations on Indirect Calibration in Analytical Chemistry

Evolution of the Quality Concept in Analytical Laboratories

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