Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy

Adami, Alessandra; Rossiter, Harry B.

doi:10.1152/japplphysiol.00445.2017

Cited by 42 publications

(73 citation statements)

References 33 publications

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“…The results of this study therefore support the validity and repeatability of the Mito6 protocol. Previous studies have measured muscle mitochondrial capacity using exercise to rest transitions and curve fitting similar to the Mito22 used in this study (Willingham and McCully, 2017;Adami and Rossiter, 2018). Collecting data points throughout the entire recovery process can result in accurate curve fits, as indicated by coefficients of variation between 8 and 12% (Ryan et al, 2013a;Southern et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Near Infrared Spectroscopy (NIRS) has been used as a noninvasive approach to measuring muscle oxygen levels (Grassi and Quaresima, 2016;Hamaoka and McCully, 2019). NIRS protocols have been developed to measure muscle mitochondria capacity (mVO 2 max) as the rate constant of recovery of muscle metabolism during the transition from exercise to rest (Hamaoka et al, 1999;Motobe et al, 2004;Ryan et al, 2012;Adami and Rossiter, 2018). The NIRS approach has shown agreement with similar measurements of phosphocreatine recovery rates (Meyer, 1988;Ryan et al, 2013b), and with mitochondrial respiration rates from tissue biopsies (Ryan et al, 2014a).…”

Section: Introductionmentioning

confidence: 98%

“…Typically, 18-26 ischemic occlusions are needed to accurately fit the metabolic rates to a mono-exponential curve approaching a steady baseline for a single rate constant to be generated (Sako et al, 2001;Motobe et al, 2004). As 2-3 trials are typically performed to obtain an accurate assessment of the recovery rate constant (Adami and Rossiter, 2018;Lagerwaard et al, 2019), 36-78 short cuff occlusions are required over 30-45 min (Willingham and McCully, 2017). This large number of cuffs can be difficult to tolerate, especially in at-risk and elderly populations.…”

Section: Introductionmentioning

confidence: 99%

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Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves

Sumner

Beard

et al. 2020

Front. Physiol.

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Background: Near-infrared spectroscopy (NIRS) has been used to measure muscle mitochondrial capacity (mVO 2 max) as the recovery rate constant of muscle metabolism after exercise. The current method requires as many as 50 short ischemic occlusions to generate two recovery rate constants. Purpose: To determine the validity and repeatability of using a 6-occlusion protocol versus one with 22 occlusions to measure muscle mitochondrial capacity. The order effect of performing multiple Mito6 test was also evaluated. Method: In two independent data sets (bicep n = 7, forearm A n = 23), recovery curves were analyzed independently using both the 6 and 22 occlusion methods. A third data set (forearm B n = 16) was generated on the forearm muscles of healthy subjects using four 6-occlusion tests performed in succession. Recovery rate constants were generated using a MATLAB routine. Results: When calculated from the same data set, the recovery rate constants were not significantly different between the 22 occlusion and 6 occlusion methods for the bicep (1.43 ± 0.33 min −1 , 1.43 ± 0.35 min −1 , p = 0.81) and the forearm A (1.97 ± 0.40 min −1 , 1.97 ± 0.43 min −1 , p = 0.90). Equivalence testing showed that the mean difference was not different than zero and the 90% confidence intervals were within 5% of the average rate constant. This was true for the Mito6 and the Mito5 * approaches. Bland-Altman analysis showed a slope of 0.21 min −1 and an r of 0.045 for the bicep dataset and a slope of −0.01 min −1 and an r of 0.045 for the forearm A dataset. When performing the four 6-occlusion tests; recovery rate constants showed no order effects (1.50 ± 0.51 min −1 , 1.42 ± 0.54 min −1 , 1.26 ± 0.41 min −1 , 1.29 ± 0.47 min −1 , P > 0.05). Conclusion: The Mito6 analysis is a valid and repeatable approach to measure mitochondrial capacity. The Mito6 protocol used fewer ischemic occlusion periods and multiple tests could be performed in succession in less time, increasing the practicality of the NIRS mitochondrial capacity test. There were no order effects for the rate constants of four repeated 6-occlusion tests of mitochondrial capacity, supporting the use of multiple tests to improve accuracy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves

Sumner

Beard

et al. 2020

Front. Physiol.

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“…,b,c, ,b; Southern et al. , ; Adami and Rossiter ). For a detailed review, readers are directed to (Grassi and Quaresima ; Willingham and McCully ).…”

Section: Introductionmentioning

confidence: 99%

“…Functional evaluation of skeletal muscle oxidative metabolism has also been assessed by pulmonary oxygen uptake (Grassi et al 1996;Rossiter et al 1999); however, this assessment is indirect, and technically challenging. Recent advancements in near-infrared spectroscopy (NIRS), however, have provided a robust, clinical platform to noninvasively assess muscle oxygen consumption/oxidative function across a wide range of muscles and disease states (McCully et al 2011;Brizendine et al 2013;Erickson et al 2013;Ryan et al 2013aRyan et al ,b,c, 2014aSouthern et al , 2015Adami and Rossiter 2017). For a detailed review, readers are directed to (Grassi and Quaresima 2016;Willingham and McCully 2017).…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience

et al. 2018

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Age is the greatest risk factor for chronic disease and is associated with a marked decline in functional capacity and quality of life. A key factor contributing to loss of function in older adults is the decline in skeletal muscle function. While the exact mechanism(s) remains incompletely understood, age‐related mitochondrial dysfunction is thought to play a major role. To explore this question further, we studied 15 independently living seniors (age: 72 ± 5 years; m/f: 4/11; BMI: 27.6 ± 5.9) and 17 young volunteers (age: 25 ± 4 years; m/f: 8/9; BMI: 24.0 ± 3.3). Skeletal muscle oxidative function was measured in forearm muscle from the recovery kinetics of muscle oxygen consumption using near‐infrared spectroscopy (NIRS). Muscle oxygen consumption was calculated as the slope of change in hemoglobin saturation during a series of rapid, supra‐systolic arterial cuff occlusions following a brief bout of exercise. Aging was associated with a significant prolongation of the time constant of oxidative recovery following exercise (51.8 ± 5.4 sec vs. 37.1 ± 2.1 sec, P = 0.04, old vs. young, respectively). This finding suggests an overall reduction in mitochondrial function with age in nonlocomotor skeletal muscle. That these data were obtained using NIRS holds great promise in gerontology for quantitative assessment of skeletal muscle oxidative function at the bed side or clinic.

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Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training‐Rheumatoid Arthritis Trial

Andonian

Ross

Zidek

et al. 2023

ACR Open Rheumatology

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Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA‐related systemic inflammation. One hypothetical means of improving overall RA CVD risk is through reduction of excess body weight and increased physical activity. Together, weight loss and physical activity can improve traditional cardiometabolic health through fat mass loss, while also improving skeletal muscle health. Additionally, disease‐related CVD risk may improve as both fat mass loss and exercise reduce systemic inflammation. To explore this hypothesis, 26 older persons with RA and overweight/obesity will be randomized to 16 weeks of a usual care control arm or to a remotely Supervised Weight Loss Plus Exercise Training (SWET) program. A caloric restriction diet (targeting 7% weight loss) will occur via a dietitian‐led intervention, with weekly weigh‐ins and group support sessions. Exercise training will consist of both aerobic training (150 minutes/week moderate‐to‐vigorous exercise) and resistance training (twice weekly). The SWET remote program will be delivered via a combination of video conference, the study YouTube channel, and study mobile applications. The primary cardiometabolic outcome is the metabolic syndrome Z score, calculated from blood pressure, waist circumference, high‐density lipoprotein cholesterol, triglycerides, and glucose. RA‐specific CVD risk will be assessed with measures of systemic inflammation, disease activity, patient‐reported outcomes, and immune cell function. The SWET‐RA trial will be the first to assess whether a remotely supervised, combined lifestyle intervention improves cardiometabolic health in an at‐risk population of older individuals with RA and overweight/obesity.

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Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy

Cited by 42 publications

References 33 publications

Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves

Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves

Near-infrared spectroscopy detects age-related differences in skeletal muscle oxidative function: promising implications for geroscience

Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training‐Rheumatoid Arthritis Trial

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