Principles and applications of nanomaterial-based hyperthermia in cancer therapy

Kang, Jin Kook; Kim, Jae Chang; Shin, Yuseon; Han, Sang M.; Won, Woong Roeck; Her, Jaewon; Park, June Yong; Oh, Kyung Taek

doi:10.1007/s12272-020-01206-5

Cited by 58 publications

(67 citation statements)

References 116 publications

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“…MH is the result of the application of an alternating magnetic field (AMF) to hyperthermia agents (such as iron oxide or gold nanoparticles) that, as a result, generate local heat at the tumor site. Such a local temperature increase induces the apoptosis or necrosis of tumor cells, which are more sensitive than normal healthy cells to the increased temperature of about 43 °C [ 5 , 6 ]. The other advantage of this approach is that MH can penetrate tissues in depth.…”

Section: Introductionmentioning

confidence: 99%

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

et al. 2020

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The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

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Section: Introductionmentioning

confidence: 99%

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

et al. 2020

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“…Since the 1980s, mild hyperthermia (heating tumour tissue to 40.0-42.5 °C for ~ 1 h) is known to enhance the therapeutic outcomes in cancer patients, when combined with radio-, chemo-and/or immunotherapy 2,3 . Technological improvements in precise medical heating, imaging and non-invasive thermometry over the past decade have revived hyperthermia treatment (HT) as a precision cancer therapy [3][4][5][6] , particularly when used in simultaneous combination with ionizing radiation [7][8][9] . The number of ongoing HT clinical trials, either alone or in combination with different treatment modalities, evidences the increasing use of therapeutic HT (467 still ongoing clinical trials out of 1198 since 2000) 10 .…”

mentioning

confidence: 99%

Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Mendoza

Michlíková

Berger

et al. 2021

Sci Rep

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Radiotherapy can effectively kill malignant cells, but the doses required to cure cancer patients may inflict severe collateral damage to adjacent healthy tissues. Recent technological advances in the clinical application has revitalized hyperthermia treatment (HT) as an option to improve radiotherapy (RT) outcomes. Understanding the synergistic effect of simultaneous thermoradiotherapy via mathematical modelling is essential for treatment planning. We here propose a theoretical model in which the thermal enhancement ratio (TER) relates to the cell fraction being radiosensitised by the infliction of sublethal damage through HT. Further damage finally kills the cell or abrogates its proliferative capacity in a non-reversible process. We suggest the TER to be proportional to the energy invested in the sensitisation, which is modelled as a simple rate process. Assuming protein denaturation as the main driver of HT-induced sublethal damage and considering the temperature dependence of the heat capacity of cellular proteins, the sensitisation rates were found to depend exponentially on temperature; in agreement with previous empirical observations. Our findings point towards an improved definition of thermal dose in concordance with the thermodynamics of protein denaturation. Our predictions well reproduce experimental in vitro and in vivo data, explaining the thermal modulation of cellular radioresponse for simultaneous thermoradiotherapy.

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“…Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy for decades. Recent technological advancements, particularly in nanomaterial-based hyperthermia, have renewed interest in its use [ 1 , 2 ]. Aside from its effects on perfusion and oxygenation of cancer tissues [ 3 ], hyperthermia can enhance the efficacy of DNA-damaging treatments such as radiotherapy and chemotherapy [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperthermia is an anti-cancer treatment that involves tumor heating using an exogenous energy source. Technological advancement has widened the therapeutic window of hyperthermia to 40–45 °C [ 1 , 2 ]. Hyperthermia combined with radio- or chemotherapy improves treatment outcomes which can be explained by multiple factors [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization

Luzhin

Avanesyan

Velichko

et al. 2020

Cells

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Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy for decades. In addition to its effects on perfusion and oxygenation of cancer tissues, hyperthermia can enhance the efficacy of DNA-damaging treatments such as radiotherapy and chemotherapy. Although it is believed that the adjuvant effects are based on hyperthermia-induced dysfunction of DNA repair systems, the mechanisms of these dysfunctions remain elusive. Here, we propose that elevated temperatures can induce chromatin trapping (c-trapping) of essential factors, particularly those involved in DNA repair, and thus enhance the sensitization of cancer cells to DNA-damaging therapeutics. Using mass spectrometry-based proteomics, we identified proteins that could potentially undergo c-trapping in response to hyperthermia. Functional analyses of several identified factors involved in DNA repair demonstrated that c-trapping could indeed be a mechanism of hyperthermia-induced transient deficiency of DNA repair systems. Based on our proteomics data, we showed for the first time that hyperthermia could inhibit maturation of Okazaki fragments and activate a corresponding poly(ADP-ribose) polymerase-dependent DNA damage response. Together, our data suggest that chromatin trapping of factors involved in DNA repair and replication contributes to heat-induced radio- and chemosensitization.

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Principles and applications of nanomaterial-based hyperthermia in cancer therapy

Cited by 58 publications

References 116 publications

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Mathematical model for the thermal enhancement of radiation response: thermodynamic approach

Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization

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