The importance of vocational education curriculum setting in special education schools cannot be ignored. On the basis of following the teaching purpose, schools need to plan school-based courses conducive to the lifelong development of students according to their own development needs. The curriculum arrangement should take students as the main body, pay attention to their long-term development needs, and provide students with more opportunities for active participation and hands-on practice, so as to cultivate their social practical skills and good habits. The overall teaching arrangement should reflect a scientific, reasonable, holistic, and practical teaching structure. In view of this, this article will analyze the effectiveness of vocational education in special education schools and put forward some strategies for reference.