Primordial respiratory-like rhythm generation in the vertebrate embryo

Champagnat, Jean; Fortin, Gilles

doi:10.1016/s0166-2236(96)10078-3

Cited by 92 publications

(43 citation statements)

References 52 publications

(48 reference statements)

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“…It should be kept in mind that within the brainstem and spinal cord neural circuits capable of generating rhythmic motor behaviors develop in a segmental fashion (see Kinkead, 2009;Taylor et al, 2010). Each major group of respiratory motoneurons has been suggested to be coupled to its own rhythm generator (Champagnat and Fortin, 1997). This segmental configuration appears to be transient and reorganized over the course of the development to produce coordinated and effective movements (Kinkead, 2009).…”

Section: Considerations On the Evolutionary Trends In Respiratory Rhymentioning

confidence: 99%

Neural mechanisms underlying respiratory rhythm generation in the lamprey

Bongianni

Mutolo

Cinelli

et al. 2016

Respiratory Physiology & Neurobiology

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a b s t r a c tThe isolated brainstem of the adult lamprey spontaneously generates respiratory activity. The paratrigeminal respiratory group (pTRG), the proposed respiratory central pattern generator, has been anatomically and functionally characterized. It is sensitive to opioids, neurokinins and acetylcholine. Excitatory amino acids, but not GABA and glycine, play a crucial role in the respiratory rhythmogenesis. These results are corroborated by immunohistochemical data. While only GABA exerts an important modulatory control on the pTRG, both GABA and glycine markedly influence the respiratory frequency via neurons projecting from the vagal motoneuron region to the pTRG. Noticeably, the removal of GABAergic transmission within the pTRG causes the resumption of rhythmic activity during apnea induced by blockade of glutamatergic transmission. The same result is obtained by microinjections of substance P or nicotine into the pTRG during apnea. The results prompted us to present some considerations on the phylogenesis of respiratory pattern generation. They may also encourage comparative studies on the basic mechanisms underlying respiratory rhythmogenesis of vertebrates.

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Section: Considerations On the Evolutionary Trends In Respiratory Rhymentioning

confidence: 99%

Neural mechanisms underlying respiratory rhythm generation in the lamprey

Bongianni

Mutolo

Cinelli

et al. 2016

Respiratory Physiology & Neurobiology

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“…It is postulated that the early rhythm in hindbrain motor neurons is modified in the older animal to play a role in the oral components of the respiratory rhythm. This work and the relationship to late fetal and adult respiratory rhythms are reviewed in Champagnat and Fortin (95).…”

Section: Nature Of Spontaneous Activitymentioning

confidence: 99%

Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells

Moody¹,

Bosma²

2005

Physiological Reviews

341

323

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At specific stages of development, nerve and muscle cells generate spontaneous electrical activity that is required for normal maturation of intrinsic excitability and synaptic connectivity. The patterns of this spontaneous activity are not simply immature versions of the mature activity, but rather are highly specialized to initiate and control many aspects of neuronal development. The configuration of voltage- and ligand-gated ion channels that are expressed early in development regulate the timing and waveform of this activity. They also regulate Ca2+ influx during spontaneous activity, which is the first step in triggering activity-dependent developmental programs. For these reasons, the properties of voltage- and ligand-gated ion channels expressed by developing neurons and muscle cells often differ markedly from those of adult cells. When viewed from this perspective, the reasons for complex patterns of ion channel emergence and regression during development become much clearer.

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“…Electrically encoded information within the CNS is conducted through specific neuronal circuits, which enable the expression of proper behavior. In the developing CNS, immature synaptic networks generate correlated neuronal activity in a wide range (for reviews, see Ben-Ari 2001;Champagnat and Fortin 1997;Feller 1999;O'Donovan 1999;Roerig and Feller 2000). Although the roles of this activity during ontogenesis remain unresolved, one traditional view is that it contributes to the activity-dependent developmental organization of neuronal circuits with specific functions (Goodman and Shatz 1993;Hanse et al 1997;Katz and Shatz 1996;Sur and Leamey 2001).…”

Section: Introductionmentioning

confidence: 99%

Optical Imaging of Large-Scale Correlated Wave Activity in the Developing Rat CNS

Momose‐Sato

Honda²,

Sasaki³

et al. 2005

Journal of Neurophysiology

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. Correlated neuronal activity plays a fundamental role in the development of the nervous system. Using a multiple-site optical recording technique with a fast voltage-sensitive dye, we previously reported a novel form of correlated activity in the chick embryo, which showed wide propagation throughout the CNS. In this study, we report that similar wave activity is generated in the embryonic rat CNS. Electrical stimulation applied to the cervical cord evoked wave activity that traveled over a wide region of the CNS including the medulla, pons, midbrain, diencephalon, and spinal cord. Small signals were also detected from the cerebellum and part of the cerebrum. Stimulation applied to the cranial nerves such as the trigeminal and vagus nerves evoked waves with similar patterns, indicating that the wave is triggered by external sensory inputs. This wave activity was inhibited by glutamate-, acetylcholine-, GABA-and glycine-receptor antagonists in addition to gap junction blockers such as octanol and 18␤-glycyrrhetinic acid. In the immunohistochemical study, significant immunoreactivity of connexin26 and connexin32 was also observed. Wave activity detected with a voltage-sensitive dye was accompanied by a Ca 2ϩ -wave, indicating that it not only provides electrical synchrony but also biochemical signals associated with [Ca 2ϩ ] i elevation. These characteristics of the wave activity are similar to those of the depolarization wave reported in the chick embryo, suggesting that the large-scale depolarization wave is globally generated across different species.

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Primordial respiratory-like rhythm generation in the vertebrate embryo

Cited by 92 publications

References 52 publications

Neural mechanisms underlying respiratory rhythm generation in the lamprey

Neural mechanisms underlying respiratory rhythm generation in the lamprey

Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells

Optical Imaging of Large-Scale Correlated Wave Activity in the Developing Rat CNS

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