Primitive Neuroectodermal Tumors of the Kidney

Narayanan, Geetha; Rajan, Varun; Preethi, T. R.

doi:10.1080/08998280.2017.11929588

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…The presenting symptoms of renal PNET are nonspecific, including flank pain, abdominal mass, hematuria, and other symptoms related to genitourinary infections ( 9 ). A retrospective study done by Sun et al showed most patients (87%) having renal PNET on the left side, but our study and case series conducted by Narayanan et al revealed it to be on the right kidney in most of the patients ( 10 , 11 ).…”

Section: Discussioncontrasting

confidence: 72%

Do Primitive Neuroectodermal Tumors of the Kidney Have a Predilection for Inferior Vena Cava Involvement? A Case Series and Review of the Literature

Hota

Kalra

Dorairajan

et al. 2020

jkcvhl

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The primitive neuroectodermal tumor (PNET) of the kidney is an extremely rare neoplasm, the diagnosis of which mainly depends upon histopathology, immunohistochemistry (IHC), and cytogenetics. A handful of cases reported in the literature mention about aggressive features of this neoplasm. The purpose of our study was to review our experience in not only the diagnosis and management of the patients with renal PNET but also to highlight its propensity to involve inferior vena cava (IVC) and also present a rare occurrence of Ewing’s sarcoma (ES)/PNET of the renal pelvis. The clinical, operative, and histopathology records of four patients of renal PNET treated between January 2017 and December 2019 were reviewed and data analyzed concerning the available literature. Out of the four patients treated, two had level III and IV IVC thrombus, and one had dense desmoplastic adhesions with the IVC wall. One of the cases had a rare presentation of ES/PNET of the renal pelvis. All patients were managed surgically, while only one patient received adjuvant chemotherapy and following up with remission for the last 2 years and 4 months. On IHC, cluster of differentiation-99 (CD-99) was positive in all patients, and three were positive for Friend leukemia integration-1. PNET of the kidney is primarily an immunohistopathological diagnosis. This neoplasm has an increased propensity for the local invasion of surrounding structures. A multimodality approach with surgery, chemotherapy, and radiotherapy could offer better outcomes, although the prognosis of these tumors remains poor.

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Section: Discussioncontrasting

confidence: 72%

Do Primitive Neuroectodermal Tumors of the Kidney Have a Predilection for Inferior Vena Cava Involvement? A Case Series and Review of the Literature

Hota

Kalra

Dorairajan

et al. 2020

jkcvhl

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“…5 Most of the studies have mentioned that renal PNET is more common in adolescents and young adults. 6,7 But in our study, two of the three cases were elderly over 60 years of age. Only a few case reports have mentioned renal PNET in elderly patients.…”

Section: Discussionmentioning

confidence: 48%

Primitive neuroectodermal tumor of kidney in elderly -A case series with review of literature

Kavitha¹,

Kottangal²,

Kuruvila³

et al. 2022

JDPO

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Primitive neuroectodermal tumor of the kidney (PNET) is a very rare and highly aggressive tumor commonly seen in young adolescents. These tumors are rare in patients over 40 years. Reports of renal PNET in elderly patients over 60 years are even rarer.We report three cases of renal PNET in adult patients diagnosed over a period of three years. Among the three patients, two were above 60 years of age and the third patient was a 39-year-old male. All the three patients had extensive venous thrombosis at the time of presentation. One of the patients succumbed to death in the immediate post-operative period and the other two received chemotherapy.Renal PNET owing to its rare occurrence in middle-aged and elderly poses a diagnostic challenge to the pathologist. The clinical and radiological findings have limitations in the accurate diagnosis. Thorough morphological evaluation along with immunohistochemistry and cytogenetic analysis help in arriving at a correct diagnosis. An accurate diagnosis is crucial for the initiation of proper treatment.

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“…Only 1 case was older than 55 years. This feature was highlighted by Narayanan et al 8 , Shi Wei et al 14 and Magro et al 19 mentioning that this tumor involves mainly children and young adults. This tumor was more common in males in our study 9/12, 75%, which was also mentioned by other studies.…”

Section: Discussionmentioning

confidence: 87%

Use of Immunohistochemistry in the differential diagnosis of Small Round Blue cell tumors.

Mudassar¹,

Baloch²,

Hameed

et al. 2020

TPMJ

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Objectives: Objective of the study is to differentiate and sub-categorize malignant small round blue cell tumors by using immune-histochemistry. Study Design: Descriptive Observational study. Setting: Meezan Private Lab, Faisalabad, Pakistan. Period: 5 years, from July 2014 to June 2019. Material & Methods: Sample Size: 126 cases of Round blue cells tumors. Sampling Technique: Non probability purposive sampling. Data Collection Procedure: 126 cases which fulfilled the inclusion and exclusion criteria were selected for the study. All these cases were subjected to immunohistochemistry. The IHC technique used was based on Peroxidase anti-peroxidase (PAP) method. Based on site and morphological clues, initially Leukocyte common antigen (LCA), Myogenin, Cytokeratin (CK), Desmin, chromogranin, Neuron specific enolase (NSE), S-100, Smooth muscle actine (SMA) and CD99 were used. Further immune stains panels were used afterwards, as and when needed like CD20, CD3, CD30, BCL2, CD117, Ki-67, Tdt, synaptophysin, SMA, CD56, Melan A, HMB45 and WT1. Results: Out of 126 cases of small round blue cell tumors, 35 (27.8 %) cases were diagnosed as diffuse large B cell lymphoma, 6 as Lymphoblastic lymphoma, 4 as Burkitt’s lymphoma, and 6 cases as NK/T cell lymphoma. Ewing’s sarcoma/PNET (12/126, 9.5%) was the 2nd highest in frequency, followed by Rhabdomyosarcoma, Synovial sarcoma, Malignant melanoma, and Germ cell tumor, which were all 9/126 each with 7.1 %. Conclusion: Immunohistochemistry is an important tool for appropriate and clear differential diagnosis of malignant small round blue cell tumors of childhood.

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Primitive Neuroectodermal Tumors of the Kidney

Cited by 7 publications

References 15 publications

Do Primitive Neuroectodermal Tumors of the Kidney Have a Predilection for Inferior Vena Cava Involvement? A Case Series and Review of the Literature

Do Primitive Neuroectodermal Tumors of the Kidney Have a Predilection for Inferior Vena Cava Involvement? A Case Series and Review of the Literature

Primitive neuroectodermal tumor of kidney in elderly -A case series with review of literature

Use of Immunohistochemistry in the differential diagnosis of Small Round Blue cell tumors.

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