Primitive Neuroectodermal Tumor of the Kidney: A Single-Institute Series of Six Patients from China

Huang, Jiwei; Zeng, Jin; Dong, Baijun; Chen, Yonghui; Kong, Wen; Liu, Qiang; Xue, Wei; Liu, Dongming; Huang, Yiran

doi:10.1159/000342647

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…Xinchun Li [ 9 ] found that pPNET arising in the abdomen and pelvis occurred more frequently in adults. Huang J [ 10 ] found that patients with pPNET arising in the kidney had a mean age of 35.0 years old. Dick EA [ 8 ] reported that peripheral PNET occurred more frequently in women.…”

Section: Discussionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Tan

Zhang

et al. 2014

Oncotarget

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BackgroundThe peripheral primitive neuroectodermal tumor (pPNET) is a rare malignant tumor originating from neuroectoderm. The accurate diagnosis is essential for the treatment of pPNET.Methodswe performed the largest cases of retrospective analysis thus far to review the unique computed tomography (CT), magnetic resonance imaging (MRI), and clinicopathological features of pPNET. The tumor location, morphological features, signal intensity, contrast enhancement characteristics, and involvement of local soft tissues of 36 pPNETs were assessed.ResultsOur results showed that there were more men (25/36) than women pPNETs patients. Unenhanced MRI (16 cases) showed that 14 cases were isointense and 2 cases were hypointense on T1WI. Nine cases were isointense and 7 were hyperintense on T2WI. Most pPNETs had heterogeneous signal intensity with small necrosis (CT: 31/36; MRI: 14/16) as well as heterogeneous enhancement (CT: 34/30; MRI: 15/16). The tumors usually had ill-defined borders and irregular shapes (CT: 30/36; MRI: 15/16). Pathologic exam showed small areas of necrosis in all tumors.ConclusionsThe diagnosis of pPNET should be suggested in young men when the imaging depicts a single large ill-defined solid mass with small area of necrosis, especially for those whose images show iso-intense on T1WI and T2WI and have heterogeneous enhancement.

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Section: Discussionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Tan

Zhang

et al. 2014

Oncotarget

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“…survival advantage [2,3]. For instance, an ESK/PNET patient underwent radical nephroureterectomy; the patient was disease-free (i.e., no recurrence or metastasis) at 18 months postoperatively [4].…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing sarcoma of the kidney: a case report and treatment review

et al. 2017

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Ewing sarcomas/primitive neuroectodermal tumors (ES/PNET) of the kidney are rarely found high-grade malignant tumors, offering poor prognosis. Although established treatment guidelines for ES of kidney are scarce, a multi-modality treatment approached is typically implemented. Herein, we report a 14-year-old female patient with ES of right kidney. Post-nephrectomy disease recurrence was treated with chemotherapy (i.e., vincristine, doxorubicin and cyclophosphamide); marked reduction in tumor size (i.e., from 18.5 9 11.3 cm 2 to 3.7 9 2.2 cm 2 ; *96% reduction in size) as per computed tomography images was observed. We present our treatment experience and review from the available literature.

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“…For final analysis, 10 studies were included. [5][6][7][8][9][10][11][12][13][14] Data from all these 10 studies was extracted and tabulated in pre-defined format.…”

Section: Search Strategy and Selectionmentioning

confidence: 99%

Primary primitive neuroectodermal tumour of the kidney in adults: Experience of managing 12 cases with systematic review and pooled analysis of literature

Sharma

Kakkar

Singh

et al. 2021

Int J Clinical Practice

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Introduction: Primitive neuroectodermal tumor (PNET) of the kidney is unusual in adults. These tumours are diagnosed mainly on histopathology and that too sometimes has limitations. With this study, we aimed to review our clinical and histopathological data of patients with renal PNET and reviewing the world literature. Methods:In this retrospective study, we reviewed our database from January 2006 to July 2018 to include all the cases of primary PNET of the kidney. We also performed systematic literature search to identify all the relevant series on renal PNET.Results: A total of 12 patients including 5 men and 7 women were managed during the above mentioned period. Out of these 7 patients, 2 patients had metastasis at diagnosis, one had locally advanced disease, 6 underwent radical nephrectomy, 5 patients received adjuvant chemotherapy (two currently receiving) and only 1 patient received adjuvant radiotherapy (RT). On Immunohistochemistry (IHC), CD99 and FLI1 were positive in all the patients. Median survival was 10 months. In our review 10 studies were included, 38.6% of the patients had metastatic disease and 10.7% had locally advanced disease at diagnosis. Overall mean survival was 33.75 months. CD99 and FLI1 were positive in 94.3% and 78.5%, respectively. Conclusion: PNET remains a pathological diagnosis and IHC has important place in diagnosis of PNET. Locally advanced and metastatic disease is common at diagnosis leading to overall poor survival.

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Primitive Neuroectodermal Tumor of the Kidney: A Single-Institute Series of Six Patients from China

Cited by 5 publications

References 33 publications

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Peripheral primitive neuroectodermal tumor: Dynamic CT, MRI and clinicopathological characteristics - analysis of 36 cases and review of the literature

Primary Ewing sarcoma of the kidney: a case report and treatment review

Primary primitive neuroectodermal tumour of the kidney in adults: Experience of managing 12 cases with systematic review and pooled analysis of literature

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