Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature

Patnaik, Nivedita; Mishra, Kiran; Saini, Pradeep; Agarwal, Nitin

doi:10.4103/0974-7796.150537

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…The main microscopic pathology finding is the presence of small round cell tumors with high nucleus/cytoplasm ratio and may be present rosettes. Pathology may show nephrogenic rests in approximately 25-40% cases 12 . Immunohistochemistry may be essential in the differentiation of WT, which is WT1 positive and rarely positive for CD99, this one a very important piece of information to differentiate WT from PNET neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Wilms Tumor in Adults: Case Report and Review of the Literature

Bereza

Maneti²,

Cathcart³

et al. 2017

BJMHH

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Wilms Tumor (WT) is an extremely rare neoplasia in adults. It represents 95% and 1% of all renal tumors, in adults and children respectively. Clinical symptoms are also distinct between adults and children. In adults, symptoms are usually abdominal pain and hematuria, on the other hand, pediatric patients frequently present with an asymptomatic abdominal mass. The recommended treatment for WT in adults follows protocols established for pediatric patients. Currently, the 5-year overall survival rate for adults with WT is of approximately 90%. The adoption of multimodal therapy systematized, and proposed by current protocols, allowed the results to become much more robust, with a significant improvement from less than 30% to 90%. However, recent reviews suggest a worse outcome for adults when compared to children, even when submitted to the same treatment regimen, and comparable according to histology and tumor stage.We present a case of a 26 years-old male patient, who underwent surgery to treat a solid renal mass. Pathological report demonstrated a Wilms tumor. The patiente also received adjuvant chemotherapy with dactinomycin and vincristine. After 12 months follow-up, patient has no evidence of disease.

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Section: Discussionmentioning

confidence: 99%

Wilms Tumor in Adults: Case Report and Review of the Literature

Bereza

Maneti²,

Cathcart³

et al. 2017

BJMHH

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“…Since then, most features of this neoplasm have been presented through case reports and there are few original articles in this context (6)(7)(8). Based on the literature reviewed, less than 100 cases of PNET of kidney have been reported to date.…”

Section: Discussionmentioning

confidence: 99%

“…The most common clinical presentation is a vague pain in the flank. Imaging findings, such as huge renal mass (more than 10 cm in diameter) is prevalent (6,7,11). As the tumor is highly aggressive, it is often diagnosed at an advanced stage with distant metastasis, with lung being one of the most common sites (4,12,13).…”

Section: Discussionmentioning

confidence: 99%

Unilateral Renal Primitive Neuroectodermal Tumor (PNET)

et al. 2017

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Introduction: Primitive neuroectodermal tumor (PNET) of kidney is a rare clinical condition. We report a young girl with PNET of kidney. Case Presentation: A 14-year-old female presented with chronic flank pain. Imaging studies revealed a huge renal mass with left renal vein thrombosis. Histopathological findings were consistent with PNET, which was later confirmed by immunohistochemistry and she received adjuvant chemotherapy. Conclusions: PNET is a rare clinical condition in urology and it should be considered in young patients with a renal mass, especially when it is huge. Treatment plan includes radical nephrectomy along with neoadjuvant chemotherapy.

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“…The presence of blastemal cells is the predominant histological component of Wilms' tumors, and it appears in distinctive patterns. Blastemal cells exhibit scant cytoplasm and are very small, mitotically active, with rotund and overlapping nuclei containing coarsely distributed chromatin and evenly small nucleoli (17). An epithelial component is present in several Wilms' tumors, and this feature may be represented by primitive structures merely recognizable as tubular formations.…”

Section: Discussionmentioning

confidence: 99%

Wilms' tumor in a 51-year-old patient: An extremely rare case and review of the literature

Jin

et al. 2016

Molecular and Clinical Oncology

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Wilms tumor or nephroblastoma is a common kidney malignant tumor in childhood, accounting for ~5% of all pediatric tumors. At present, reports on Wilms' tumor occurring in adults, particularly at ages >30 years, are extremely rare. The majority of the cases of adult Wilms' tumor are closely associated with chemotherapy. Furthermore, in rare cases, Wilms' tumor is characterized by three classic types of cells, namely blastemal, stromal and epithelial cells. We herein report a case of Wilms' tumor with three classic types of cells on histological examination in a 51 year-old male patient who had received prior chemotherapy. The patient promptly underwent radical nephrectomy and remains alive. A review of previously presented cases of adult Wilms' tumor from PubMed database was also performed.

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Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature

Cited by 9 publications

References 7 publications

Wilms Tumor in Adults: Case Report and Review of the Literature

Wilms Tumor in Adults: Case Report and Review of the Literature

Unilateral Renal Primitive Neuroectodermal Tumor (PNET)

Wilms' tumor in a 51-year-old patient: An extremely rare case and review of the literature

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