Primitive cerebral melanoma: case report and review of the literature

Crasto, S.; Soffietti, Riccardo; Bradac, Gianni Boris; Boldorini, Renzo

doi:10.1016/s0090-3019(01)00348-2

Cited by 79 publications

(71 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Primary CNS malignant melanoma has occurred in the spine, [4][5][6]10,11,19,26) suprasellar region, 3,6,24) cerebral region, 6,7,12,17) pineal region, 18) cerebellopontine angle, 13,25) spinal nerve root, 22,23) and leptomeninges. 16) Forty cases of primary spinal malignant melanoma have been reported, [4][5][6]10,11,19,26) including 14 with dissemination from the primary CNS malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 49-year-old man was admitted suffering from headache persisting for a month. He had a history of primary spinal intramedullary malignant melanoma at the T6 level 18 years previously, which had remained stable for 18 years. Magnetic resonance imaging revealed central nervous system (CNS) dissemination of malignant melanoma. Whole brain radiation therapy (30 Gy), local radiation therapy (15 Gy), and routine intrathecal injection of interferon beta were performed. The progression of CNS dissemination of malignant melanoma was controlled without neurological deterioration for 38 months. The prognosis for primary CNS malignant melanomas better than that for cutaneous melanoma. However, the clinical course is still unknown, and CNS dissemination is regarded fatal. The unusually long survival in the present case indicates the effectiveness of the combined radiotherapy and interferon therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…While metastatic melanoma is a frequent cause of CNS metastasis, primary intracranial melanoma accounts for only 1% of all melanomas [65]. Meningeal melanomas can rarely arise from the pachymeninx (dura mater) or more often from the leptomeningx (arachnoidea mater and pia mater) [66].…”

Section: Meningeal Melanomamentioning

confidence: 99%

“…Diagnosis is mostly made by neuroradiologic examination followed by neurosurgical excision and histological examination or less frequently by cytological analysis of the cerebrospinal fluid. Cutaneous, mucosal, or choroidal melanomas have to be ruled out [65,70,71]. The meningeal melanomas must be distinguished from the meningeal melanocytoma which is a rare benign melanocytic tumor originating from melanocytes of the leptomeninges occurring predominantly in the posterior fossa or the upper spinal cord in adults.…”

Section: Meningeal Melanomamentioning

confidence: 99%

Primary Extracutaneous Malignant Melanoma: A Comprehensive Review with Emphasis on Treatment

et al. 2004

View full text Add to dashboard Cite

Extracutaneous malignant melanomas (EMM) require special consideration in the field of oncology due to their rareness and – depending on the localization – the frequency of late diagnosis with consecutive poor prognosis. Only 4–5% of all primary melanomas do not arise from the skin. Most frequently they originate from the mucous membranes lining the respiratory, digestive, and genitourinary tracts or in the eyes as well as in the cerebral meninges. Extracutaneous melanomas are considered to be biologically more aggressive than cutaneous melanomas. The Clark level and Breslow index used for evaluation of cutaneous melanomas are not applicable to EMM and, at present, there are no consistent, internationally accepted therapy standards for this form of the disease. For this reason, this review focuses primarily on the literature pertaining to therapeutic strategies as well as epidemiologic, biological, and diagnostic aspects of this disease.

show abstract

“…Our patient presented with slowly progressing chiasmal syndrome and a hypopituitarism without posterior pituitary dysfunction. Seventy percent of patients with pituitary metastases of melanoma have multiple metastases spread throughout all organs [11,14,18,19], although it is exceptional to discover a melanoma in a patient with a unique pituitary metastasis [12,20]. In our patient an exhaustive search did not detect any metastases, and an extensive ophthalmologic and dermatologic work up failed to find evidence of any other primary site.…”

Section: Discussionmentioning

confidence: 55%