Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering

Chan, Kiat Hwa; Zhuo, Shuangmu; Ni, Ming

doi:10.7150/ijms.12658

Cited by 28 publications

(20 citation statements)

References 77 publications

(83 reference statements)

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“…Surface properties can alter the protein adhesion and give rise to varying cell response accordingly. Different fabrication techniques provide control over morphology of the scaffolds and further functionalization of the materials can be applied to immobilize biochemical agents [59,60]. The piezoelectric constants and ferroelectricity of the piezoelectric materials can be optimized and the topographical characteristics tailored according to requirement.…”

Section: Surface Charactermentioning

confidence: 99%

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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Electrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing interest of the scientific community and compelling results of the published research articles has been the motivation of this review article. This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials. The review of both material and cellular aspects on this topic ensures that this paper appeals to both material scientists and tissue engineers.

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Section: Surface Charactermentioning

confidence: 99%

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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“…As discussed, nHA based nanocomposites have already shown promising in vitro , in vivo and clinical results, therefore, their translation for human applications is bound to expand in the near future. One interesting factor to further improve the clinical use of these materials is their enhanced interaction with mesenchymal stem cells [ 100 , 101 ]. Stem cells are playing a crucial role in furthering the achievements in the field of bone tissue engineering and regeneration with clinical translation as the end goal.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Nanohydroxyapatite Effect on the Degradation, Osteoconduction and Mechanical Properties of Polymeric Bone Tissue Engineered Scaffolds

Salmasi¹,

Nayyer²,

Seifalian³

et al. 2016

TOORTHJ

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BACKGROUNDStatistical reports show that every year around the world approximately 15 million bone fractures occur; of which up to 10% fail to heal completely and hence lead to complications of non-union healing. In the past, autografts or allografts were used as the “gold standard” of treating such defects. However, due to various limitations and risks associated with these sources of bone grafts, other avenues have been extensively investigated through which bone tissue engineering; in particular engineering of synthetic bone graft substitutes, has been recognised as a promising alternative to the traditional methods.METHODSA selective literature search was performed.RESULTSBone tissue engineering offers unlimited supply, eliminated risk of disease transmission and relatively low cost. It could also lead to patient specific design and manufacture of implants, prosthesis and bone related devices. A potentially promising building block for a suitable scaffold is synthetic nanohydroxyapatite incorporated into synthetic polymers. Incorporation of nanohydroxyapatite into synthetic polymers has shown promising bioactivity, osteoconductivity, mechanical properties and degradation profile compared to other techniques previously considered.CONCLUSIONScientific research, through extensive physiochemical characterisation, in vitro and in vivo assessment has brought together the optimum characteristics of nanohydroxyapatite and various types of synthetic polymers in order to develop nanocomposites of suitable nature for bone tissue engineering. The aim of the present article is to review and update various aspects involved in incorporation of synthetic nanohydroxyapatite into synthetic polymers, in terms of their potentials to promote bone growth and regeneration in vitro, in vivo and consequently in clinical applications.

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“…There has been also interest in looking at combination therapies to simultaneously modulate two processes [6]. On the other hand, there are also attempts to increase fracture healing in osteoporosis patients which include development of biomaterial scaffolds [7] and modification of existing bone surfaces to promote native bone growth [8]. Although substantial improvements in the treatment of osteoporosis during recent years, osteoporotic fractures are still a major clinical challenge in especially in the elderly due to impaired healing.…”

Section: Introductionmentioning

confidence: 99%

Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action

Marycz¹,

Sobierajska²,

Roecken³

et al. 2020

J Nanobiotechnol

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Background: Prevalence of osteoporosis is rapidly growing and so searching for novel therapeutics. Yet, there is no drug on the market available to modulate osteoclasts and osteoblasts activity simultaneously. Thus in presented research we decided to fabricate nanocomposite able to: (i) enhance osteogenic differentiation of osteoblast, (i) reduce osteoclasts activity and (iii) reduce pro-inflammatory microenvironment. As a consequence we expect that fabricated material will be able to inhibit bone loss during osteoporosis. Results:The α-Fe 2 O 3 /γ-Fe 2 O 3 nanocomposite (IOs) was prepared using the modified sol-gel method. The structural properties, size, morphology and Zeta-potential of the particles were studied by means of XRPD (X-ray powder diffraction), SEM (Scanning Electron Microscopy), PALS and DLS techniques. The identification of both phases was checked by the use of Raman spectroscopy and Mössbauer measurement. Moreover, the magnetic properties of the obtained IOs nanoparticles were determined. Then biological properties of material were investigated with osteoblast (MC3T3), osteoclasts (4B12) and macrophages (RAW 264.7) in the presence or absence of magnetic field, using confocal microscope, RT-qPCR, western blot and cell analyser. Here we have found that fabricated IOs: (i) do not elicit immune response; (ii) reduce inflammation; (iii) enhance osteogenic differentiation of osteoblasts; (iv) modulates integrin expression and (v) triggers apoptosis of osteoclasts. Conclusion:Fabricated by our group α-Fe 2 O 3 /γ-Fe 2 O 3 nanocomposite may become an justified and effective therapeutic intervention during osteoporosis treatment.

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Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering

Cited by 28 publications

References 77 publications

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Nanohydroxyapatite Effect on the Degradation, Osteoconduction and Mechanical Properties of Polymeric Bone Tissue Engineered Scaffolds

Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action

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