Priming the pores of mesoporous silica nanoparticles with an in-built RAFT agent for anchoring a thermally responsive polymer

Mishra, Smrutirekha; Hook, James M.; Nebhani, Leena

doi:10.1016/j.micromeso.2018.10.012

Cited by 25 publications

(12 citation statements)

References 40 publications

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“…In the synthesis system of FC2, CTA + cations and silicate species (from TEOS hydrolysis and condensation), fluorocarbon anions can counterpart the positively charged head groups of CTA + and insert into the hydrophobic part of micelles, leading to changes in hydrophobic conditions [14]. Herein, by adjusting the ratio of FC2 and CTAB, it is possible to change the structure of MSNs, and at a lower R, the surface area, pore size and pore volume of MSNs were generally higher [15].…”

Section: Characterization Of Msnsmentioning

confidence: 99%

Enhanced Inhibition of Drug-Resistant Escherichia coli by Tetracycline Hydrochloride-Loaded Multipore Mesoporous Silica Nanoparticles

Wang

et al. 2022

Molecules

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Drug-resistant bacterial infections exhibit a major threat to public health. Thus, exploring a novel antibacterial with efficient inhibition is urgently needed. Herein, this paper describes three types of MSNs (MSNs-FC2-R1, MSNs-FC2-R0.75, MSNs-FC2-R0.5) with controllable pore size (4–6 nm) and particle size (30–90 nm) that were successfully prepared. The MSNs were loaded with tetracycline hydrochloride (TCH) for effective inhibition of Escherichia coli (ATCC25922) and TCH-resistant Escherichia coli (MQ776). Results showed that the loading capacity of TCH in three types of MSNs was as high as over 500 mg/g, and the cumulative release was less than 33% in 60 h. The inhibitory rate of MSNs-FC2-R0.5 loaded with TCH against E. coli and drug-resistant E. coli reached 99.9% and 92.9% at the concentration of MIC, respectively, compared with the other two types of MSNs or free TCH. Modified MSNs in our study showed a great application for long-term bacterial growth inhibition.

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Section: Characterization Of Msnsmentioning

confidence: 99%

Enhanced Inhibition of Drug-Resistant Escherichia coli by Tetracycline Hydrochloride-Loaded Multipore Mesoporous Silica Nanoparticles

Wang

et al. 2022

Molecules

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“…Although mesoporous silica has a high drug loading rate and can control the release rate of drug, the liver, kidney and other organs will non-specifically take the drug and cause systemic toxicity before the released drug reaches the target site. Therefore, researchers employ activatable functionalization concept to address this issue and mesoporous silica with the ability of stimuli-responsive drug release such as pH-responsive, [52][53][54][55] temperature-responsive, 56 redox-responsive, [57][58][59][60] enzymeresponsive, 61,62 magnetic-responsive, [63][64][65] and jointstimulus-responsive 66,67 have been well developed. However, it should be mentioned that up to now, most of them were all designed for the diagnosis and treatment of tumor.…”

Section: Surface Modification and Functionalization Of Mesoporous Silicamentioning

confidence: 99%

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha¹,

Dai²,

Song³

et al. 2021

IJN

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Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

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“…Finally, these co-polymer-grafted MSNs were applied for in-vivo studies in drug-delivery application. Mishra et al [31,32] described grafting of poly(N-isopropyl acrylamide) (PNIPAM) onto MSNs via surface-initiated RAFT polymerization. In this work, initially two different R group containing organoalkoxysilane-based RAFT agent were synthesized.…”

Section: Raft Polymerizationmentioning

confidence: 99%

Polymer Functionalization of Mesoporous Silica Nanoparticles Using Controlled Radical Polymerization Techniques

Nebhani¹,

Mishra²,

Joshi³

2020

Advances in Microporous and Mesoporous Materials

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Mesoporous silica nanoparticles (MSNs) are widely studied and are an interesting material due to its application in wide range of areas, for example, in drug delivery, catalysis, in sensors, and in adsorption and separation. Specifically, MSNs contain high surface area and large pore volume, providing high drug loading capacity, tunable pore size, surface chemistry for accommodation of a variety of guest molecules, and versatile functionalization on the external and internal surface for a broad spectrum of applications. Many new strategies have been developed for the synthesis and functionalization of mesoporous silica-based materials. The functionalization of MSNs is highly important as it leads to the development of new chemical and physical properties. Thus, preparation of these organic/inorganic hybrid structures requires facile and controlled techniques to generate enhanced properties. The grafting of polymers using controlled radical polymerization (CRP) techniques has turned out to be the best suited method to synthesize these well-defined organicinorganic hybrid MSNs. Most common polymerization techniques are atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT) polymerization, and nitroxide mediated polymerization (NMP). This chapter will be highlighting the state-of-the-art techniques for the synthesis of variety of MSNs, its functionalization using CRP techniques, and application of polymer functionalized MSNs.

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Priming the pores of mesoporous silica nanoparticles with an in-built RAFT agent for anchoring a thermally responsive polymer

Cited by 25 publications

References 40 publications

Enhanced Inhibition of Drug-Resistant Escherichia coli by Tetracycline Hydrochloride-Loaded Multipore Mesoporous Silica Nanoparticles

Enhanced Inhibition of Drug-Resistant Escherichia coli by Tetracycline Hydrochloride-Loaded Multipore Mesoporous Silica Nanoparticles

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Polymer Functionalization of Mesoporous Silica Nanoparticles Using Controlled Radical Polymerization Techniques

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