Primer on the human genome

Chondrodermatitis nodularis chronica helicis in monozygotic twins

“…Tsai and Tsao suggested that disease could be predicted using genetics 3 . As monozygotic twins have a similar genetic makeup, it is noteworthy that our patients developed CNCH almost simultaneously.…”

“…1 Tsai and Tsao suggested that disease could be predicted using genetics. 3 As monozygotic twins have a similar genetic makeup, it is noteworthy that our patients developed CNCH almost simultaneously. This temporal concordance suggests the possibility of but does not prove a partial genetic component in the pathophysiology of CNCH.…”

Small RNAs in development and disease

“…A detailed discussion of this process has been recently published. 2 The activity of genes is controlled on each level of this pathway (Fig 1, B). At the DNA level, cells have many ways to regulate how rapidly genes are transcribed.…”

The human genome: Mutating from science fiction to reality

“…Not only is this expected to yield further insights into disease processes, but perhaps most exciting, it will likely establish the foundation of predictive medicine, in which understanding of individual genomic signatures leads to the use of appropriately targeted therapy.'' 2 Advances in genomics are occurring at breakneck speed. Within a week of Dr Watson receiving his genome, two major advances were reported that will affect the lives of dermatologists: the discovery of the gene mutation for focal dermal hypoplasia (FDH) of Goltz and the reprogramming of skin fibroblasts from mice to become pluripotential stem cells.…”