Primer caso de infección neonatal por SARS-CoV-2 en España

Díaz, Clara Alonso; Maestro, María López; Pumarega, María Teresa Moral; Antón, Beatriz Flores; Alonso, Carmen Rosa Pallás

doi:10.1016/j.anpedi.2020.03.002

Cited by 46 publications

(15 citation statements)

References 4 publications

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“… Article type Country Publication stage Quality score Overall quality No. neonates Abasse 17 Case report France a PR 6 Good 1 Aghdam 18 Case report Iran PR 4 Intermediate 1 Alonso Diaz 19 Case report Spain PR 5 Intermediate 1 Alzamora 20 Case report Peru PR 3 Intermediate 1 Ayed 21 Case series Kuwait Preprint 1 Low 2 Banerjee 22 Case series India PR 2 Low 6 Barbero 23 Retrospective cohort study Spain PR n.a. Intermediate 1 Buonsenso 24 Case series Italy PR 4 Intermediate 1 Carosso 25 Case report Italy PR 4 Intermediate 1 Chacon-Aguilar 26 Case report Spain PR 5 Intermediate 1 Coronado Munoz 27 ...…”

Section: Resultsmentioning

confidence: 99%

“…Only two neonatal infections were diagnosed by the presence of IgM in newborn blood 29 , 82 : these cases qualified as possible congenital and probable postpartum acquired infections, respectively, according to the classification system 16 ; all the other cases had at least one positive RT-PCR. Nine (5.1%) neonates required delivery room resuscitation 19 , 20 , 38 , 41 , 44 , 69 , 77 , 87 and 67 (38.3%) needed to be admitted to the NICU 17 , 18 , 20 , 27 , 31 , 33 , 35 , 36 , 38 , 41 , 44 , 45 , 47 – 49 , 51 – 53 , 57 – 59 , 61 , 62 , 64 – 66 , 69 – 73 , 77 , 80 – 82 , 85 – 88 . The median NICU stay was 8 [5;18] days (min 1; max 69 days).…”

Section: Resultsmentioning

confidence: 99%

“…Inflammatory markers (C-reactive protein and procalcitonin) were increased in 15 (15.5%) out of 97 neonates 20 , 27 , 38 , 40 , 43 , 45 , 49 , 59 , 70 , 72 , 80 – 82 , 88 . Lung imaging was abnormal in 62 (64%) out of 97 neonates and consisted of an interstitial-alveolar pattern at lung ultrasound or chest X-ray and ground-glass opacities at CT-scan 17 , 19 , 21 , 23 , 27 , 29 , 32 , 36 , 38 , 44 , 45 , 51 , 53 , 55 , 58 , 59 , 64 – 66 , 69 – 71 , 73 , 77 – 80 , 82 , 85 , 88 , 90 . One neonate presenting with neurological manifestations also showed bilateral gliosis of the deep white periventricular and subcortical matter, together with signs of cerebral vasculitis, which was not totally remitted at the hospital discharge 77 .…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

et al. 2020

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A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

et al. 2020

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“…Subsequently, 4 studies[ [21] , [22] , [23] , [24] ] were excluded, as 2 studies examined infants and children but not neonates[ 23 , 24 ], while another 2 did not report any perinatal outcomes of pregnancies infected by SARS-CoV-2[ 21 , 22 ]. As a result, the present meta-analysis was based on 16 observational studies[ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ] and 44 case reports/series[ [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] ,…”

Section: Resultsmentioning

confidence: 99%

Maternal and perinatal outcomes in pregnant women infected by SARS-CoV-2: A meta-analysis

Bellos

Pandita

Panza

2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Highlights Severe disease is not common in both pregnant women and neonates. Perinatal transmission occurs rarely and may not be linked to disease severity. Vertical transmission has been assumed in 4 cases. Transmission risk is low when the infection manifests during the third trimester. Further research should provide evidence about the risk of congenital infection.

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“…In Europe, as of May 7, 2020, 1068 adult patients have required support with ECMO. 4 Although cases of pneumonia due to SARS-CoV-2 have been reported in infants 5 , children 6 and young adults, 1 these patients have generally had good outcomes and rarely required extracorporeal life support. Our patient developed severe pneumonia refractory to standard therapy and required ECMO.…”

mentioning

confidence: 99%