Primate Model for Testing Periodontal Treatment Procedures: II. Production of Contralaterally Similar Lesions

Abstract

Experimental periodontal pockets were produced bilaterally in four Rhesus monkeys. The pockets were analyzed histometrically and the resultant data were subjected to statistical analysis. There were but few significant differences between pockets on contralateral tooth surfaces, and in each case, the magnitudes of the observed differences were so small as to be of no biological significance. The use of this model system for future studies on periodontal treatment was discussed. It was shown that by utilizing only two monkeys, the model system can discern treatment effects on the measurable parameters of as little as 0.3 mm.

Focus on intrabony defects – conservative therapy

“…Such healing result can only be demonstrated if the coronal level of the connective tissue attachment prior to therapeutic intervention is known. Hence, an animal model was developed (8,9) by which practically identical periodontal defects were produced at contralateral teeth and used to evaluate the result of various treatment procedures. In addition to scaling and root planing, the modified Widman flap procedure (43) with and without the placement of previously frozen autogenus red marrow and cancerous bone or a bone substitute (beta tricalcium phosphate) were tested for their regenerative potential (10).…”

Loss of Permanent Central Incisors in a 9 Year-Old Girl Due to Severe Periodontal Damage with an Unusual Etiology: Case Report

“…8,9 The induction of periodontal disease by ligature placement has been used in animal studies previously. 10,11 Caton and Zander reported the clinical and histological characteristics of experimental periodontal lesions using orthodontic elastics placed at the gingival margin in monkeys. 12 The presence of elastics in gingival and periodontal tissues provokes an immune-inflammatory response that leads to the progressive destruction of the structural components of the periodontium.…”

Antigenicity of freeze‐dried bone aIlograft in periodontal osseous defects

“…Orthodontic elastics were placed about alternate teeth in opposing posterior segments and allowed to migrate subgingivally for 5-6 months {Caton & Zander 1975). In this manner, angular bony defects of approximately 3 mm, extending from the alveolar crest to the base of the defect were created (Caton & Kowalski 1976). This resulted in six bony defects per segment.…”