Primate microbial endocrinology: An uncharted frontier

Benavidez, Kathryn M; Iruri‐Tucker, Alec; Steiniche, Tessa; Wasserman, Michael D.

doi:10.1002/ajp.23053

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…Hypothetical models of host-microbiome interaction point out that environmental and host-related factors work in concert to sculpt bacterial communities in wild primates (Amato and Righini, 2015;Benavidez et al, 2019). Supporting this notion, here we showed that gut bacterial communities of black howler monkeys living in disturbed forest fragments could be influenced not only by food availability (as a surrogate of diet), which is a significant ecological factor contributing to shape wildlife microbiomes, but also by the host endocrine physiology.…”

Section: Discussionsupporting

confidence: 77%

“…Studies investigating the interplay between stress reactions and the gut microbiome in wildlife are still limited, but an emerging field exploring the communication between endocrine and gut microbiome systems in free ranging animals is currently developing (see Benavidez et al, 2019). Stress responses may induce intestinal disorders affecting microbial structure and/or metabolism in wild and domestic animals (Söderholm et al, 2002;Li et al, 2018;Yan et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…The gut microbiome of vertebrates is shaped by a combination of intrinsic (e.g., host genetics) and extrinsic (e.g., ecology, climate) factors which determine the structure, stability, and dynamics of bacterial communities, including diversity and function (Douglas, 2018). The host's physiological stress response, i.e., physiological reactions to noxious or threatening physical or psychological stimuli (Romero, 2004;Reeder and Kramer, 2005), has been recognized as a contributing factor of microbiome change, mediated in part by interactions within the gut-brain axis (Foster et al, 2017;Benavidez et al, 2019). That is, the complex communication between the gastrointestinal tract and the central nervous system modulates microbiome responses to stressful stimuli (Foster and McVey Neufeld, 2013;Moloney et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Environmental Stress and the Primate Microbiome: Glucocorticoids Contribute to Structure Gut Bacterial Communities of Black Howler Monkeys in Anthropogenically Disturbed Forest Fragments

Martínez-Mota

Righini²,

Mallott³

et al. 2022

Front. Ecol. Evol.

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Animals living in anthropogenically disturbed habitats are exposed to environmental stressors which can trigger physiological reactions, such as chronic elevations of glucocorticoid hormones. Physiological responses to stressors may induce changes in the gut microbiome, most likely, facilitated by the gut–brain communication. Although these effects have been observed in humans and animal models, elucidating gut bacterial changes in wild animals under natural stressful conditions is still an ongoing task. Here we analyzed the association between physiological stress related to anthropogenic forest disturbance and changes in gut bacterial communities of black howler monkeys (Alouatta pigra) living in forest fragments in Mexico. We measured individuals’ fecal glucocorticoid metabolites (fGCMs) as an index of physiological stress and created inventories of fecal bacterial communities sequencing the 16S rRNA gene to assess gut microbiome change. We evaluated environmental stress by estimating differences in food availability – feeding tree diversity and biomass – in each group’s habitat. We found that both fGCMs and food availability indices were related to gut bacterial community shifts in black howler monkeys. Furthermore, using structural equation modeling, we found that a decrease in food availability, estimated through reductions in feeding tree basal area, increased fGCMs, which in turn induced increases in bacterial richness. Our findings show that the activation of the hypothalamic–pituitary–adrenal (HPA)-axis, which is a physiological response sensitive to environmental stressors such as the ecological disturbance of a habitat, contributes to structure the gut microbiome of arboreal primates in disturbed forests.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Environmental Stress and the Primate Microbiome: Glucocorticoids Contribute to Structure Gut Bacterial Communities of Black Howler Monkeys in Anthropogenically Disturbed Forest Fragments

Martínez-Mota

Righini²,

Mallott³

et al. 2022

Front. Ecol. Evol.

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“…Additionally, microbiome time-series data sets that include hormone information, such as those that measure metabolites of steroid hormones in fecal samples, 56 , 57 will be particularly valuable for parsing out a second potential mechanism of lifetime microbial stability. Glucocorticoids have a pervasive genetic component, 58–60 and a study on primate microbial endocrinology 61 proposes that host–microbiome signaling via the endocrine system may promote microbiome stability. This suggests that one potential mechanism for the host genetic influence on microbial stability is via glucocorticoid levels.…”

Section: How Time Series Data Can Inform Host Genetics Effects On The...mentioning

confidence: 99%

How longitudinal data can contribute to our understanding of host genetic effects on the gut microbiome

2023

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A key component of microbiome research is understanding the role of host genetic influence on gut microbial composition. However, it can be difficult to link host genetics with gut microbial composition because host genetic similarity and environmental similarity are often correlated. Longitudinal microbiome data can supplement our understanding of the relative role of genetic processes in the microbiome. These data can reveal environmentally contingent host genetic effects, both in terms of controlling for environmental differences and in comparing how genetic effects differ by environment. Here, we explore four research areas where longitudinal data could lend new insights into host genetic effects on the microbiome: microbial heritability, microbial plasticity, microbial stability, and host and microbiome population genetics. We conclude with a discussion of methodological considerations for future studies.

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“…Microorganisms can not only respond to eukaryotic signal molecules, but also express a variety of host HRF, for example, during stress. As a result, a new field of microbial endocrinology has emerged, which studies the bidirectional mechanisms of signaling interaction between the microbiota and humans [ 8 , 9 ]. Undeniable evidence shows that a microorganism’s signal molecules play a significant role in the regulation of the endocrine, immune, vegetative, intestinal, and nervous systems of humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, Micrococcus luteus C01 and Alcaligenes faecalis DOS7

Лойко

Kanunnikov²,

Ганнесен

et al. 2022

Biology

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Brain natriuretic peptide (BNP) is secreted by the ventricles of the heart during overload to signal heart failure. Slight bilateral skin itching induced by BNP has been associated with response activity of the skin microbiota. In this work, we studied the effect of 25–250,000 pg BNP/mL on the growth, long-term survival, and stress (H2O2, antibiotics, salinity, heat and pH shock) resistance of human symbiont bacteria: Gram-positive Micrococcus luteus C01 and Gram-negative Alcaligenes faecalis DOS7. The effect of BNP turned out to be dose-dependent. Up to 250 pg BNP/mL made bacteria more stress resistant. At 2500 pg BNP/mL (heart failure) the thermosensitivity of the bacteria increased. Almost all considered BNP concentrations increased the resistance of bacteria to the action of tetracycline and ciprofloxacin. Both bacteria survived 1.3–1.7 times better during long-term (up to 4 months) storage. Our findings are important both for clinical medical practice and for practical application in other areas. For example, BNP can be used to obtain stress-resistant bacteria, which is important in the collection of microorganisms, as well as for the production of bacterial preparations and probiotics for cosmetology, agriculture, and waste management.

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Primate microbial endocrinology: An uncharted frontier

Cited by 5 publications

References 39 publications

Environmental Stress and the Primate Microbiome: Glucocorticoids Contribute to Structure Gut Bacterial Communities of Black Howler Monkeys in Anthropogenically Disturbed Forest Fragments

Environmental Stress and the Primate Microbiome: Glucocorticoids Contribute to Structure Gut Bacterial Communities of Black Howler Monkeys in Anthropogenically Disturbed Forest Fragments

How longitudinal data can contribute to our understanding of host genetic effects on the gut microbiome

Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, Micrococcus luteus C01 and Alcaligenes faecalis DOS7

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