Primate kidney function in hemorrhagic shock

Ee, Selkurt

doi:10.1152/ajplegacy.1969.217.4.955

Cited by 14 publications

(10 citation statements)

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“…The hypothesis that efferent vasodilatation is concerned with the development of anuria in man has been advanced by others (55,54) (4,55,57,58). Obviously, at this stage the clearance results are unreliable (55).…”

mentioning

confidence: 99%

“…The (51)(52)(53). However, in animals subjected to hemorrhagic shock and in which clearance determinations were combined with direct flow measurements, it was shown that after retransfusion of the previously removed blood the inulin clearance remained relatively lower than the para-amino hippurate (PAH) clearance, observations which suggest that efferent vasodilatation occurred (54).…”

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confidence: 99%

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Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Reubi¹,

Vorburger²,

Tuckman³

1973

J. Clin. Invest.

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A Bs T R A C T The mechanism responsible for the anuria in acute renal failure after shock is still controversial.Suppressed glomerular filtration and/or tubular backdiffusion of the filtrate are major possible causes. In the present investigation, seven patients with acute anuria, three of these seven again in the polyuric phase, six patients with moderate renal impairment, four patients with chronic renal failure, and eight subjects with normal renal function were studied by a multiple indicatordilution method in which the total renal blood flow and renal distribution volumes of indocyanine green, ['Cr]-EDTA, and 'Na were determined. In normal subjects the average values for one kidney were 582 ml/min, 42 ml, 92 ml, and 139 ml, respectively. The measurements in the patients with moderate renal impairment were similar to those in the normal subjects, but were decreased in chronic renal failure. In acute anuria, the average values were 269 ml/min, 40 ml, 101 ml, and 114 ml and the kidney volume, estimated radiographically, was increased by 40%. When expressed as milliliters per milliliters kidney, the average distribution volume of 'Na was decreased from 0.64 to 0.38. This decrease is consistent with the hypothesis that suppressed filtration is largely responsible for the anuria and that back-diffusion is, at most, a contributory factor. The apparent contradiction between the relatively well-preserved total blood flow and the suppressed filtration may be due to a combination of afferent vasoconstriction and efferent vasodilatation. This view is supported by the observation that low filtration fractions were found in clearance measurements performed during the polyuric phase.

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confidence: 99%

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confidence: 99%

Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Reubi¹,

Vorburger²,

Tuckman³

1973

J. Clin. Invest.

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“…In most of these instances, decreases in glomerular filtration rate and, to a lesser extent, total renal blood flow have been considered important. There is only limited information (Selkurt et al 1965;Selkurt, 1969) (Atherton et al 1970) and to those rapidly induced by continuous infusion of hypertonic mannitol (Atherton et al 1968a), the changes in the present experiments were induced by a very small volume (1 ml., equivalent to less than 0*5 % of total body weight) such as is used for routine I.v. administration of agents in a saline vehicle.…”

Section: Acute Effects Of Single IV Saline Injectionmentioning

confidence: 75%

“…The significant feature of these results is that after minor procedures (light ether anaesthesia, minor operative manipulations) presumed to be associated with an antidiuretic stimulus (Ginsburg & Brown, 1956) rapid reductions occurred in papillary urea and calculated osmolal concentrations. It would be expected, therefore, that owing to the reduction in the medullary osmotic force, the ability to concentrate urine would be impaired despite high water permeability of the collecting duct since it has been demonstrated previously that the urinary response to ADH depends on the medullary osmolality during various circumstances (Selkurt, 1969; Atherton, Evans, Green & Thomas, 1971;Gagnon, Grove & Flamenbaum, 1974 Raisz, Au & Scheer, 1959;surgery, Gullick & Raisz, 1960; increased renal arterial pressure, Selkurt, Womack & Daly, 1965;haemorrhagic shock, Selkurt, 1969). Reduced nephron permeability to water seems to be excluded in these experiments since reduced urinary osmolality was observed during conditions in which endogenous ADH secretion might be expected to have increased or where exogenous ADH was administered.…”

Section: Acute Effects Of Single IV Saline Injectionmentioning

confidence: 99%

Lability of renal papillary tissue composition in the rat.

Atherton¹

1978

The Journal of Physiology

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SUMMARY1. The acute effects of (a) a minor operative procedure using ether as the anaesthetic, and (b) the administration of 0-9 % saline as a single i.v. injection in the conscious rat, on renal tissue composition were studied in hydropenic and normally hydrated rats.2. The operative procedure and anaesthesia induced a rapid and transient decrease in papillary osmolality in both hydropenic and normally hydrated animals, the important contributing factor being a significant decrease in urea content.3. Administration of a small volume of saline caused a rapid decrease in urea content, and an increase in water content. 4. It is concluded that papillary composition is extremely labile, large changes being produced by relatively minor experimental procedures.

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“…Elucidation of the functional significance of these differences may depend upon studies under conditions of experi mental stress, in which investigation of the intrarenal distribution of blood flow has proved more valuable than that using classical clearance methods [Barger, 1966;Birtch et al, 1967;Pom eranz et al, 1968;Stinson et al, 1969]. In this regard, Selkurt [1969] recently reported that the renal response of owl monkeys (Aotes trivirgatus) to hemorragic shock differs from that in the dog.…”

Section: Discussionmentioning

confidence: 99%

Intrarenal Arterial Patterns in Nonhuman Primates

Stinson¹

1971

IJFP

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The vascular architecture has been studied in kidneys from five rhesus monkeys, three baboons, two chimpanzees and two dogs through the use of a silicone rubber injection method. The most important findings is the presence of subcapsular glomeruli in nonhuman primates, in contrast to man and dog. The study also confirms the presence of superficial cortical arteries in these primates. While the functional significance of such findings is not known, it is suggested that these species would serve as ideal models for micropuncture study of glomerular function.

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Primate kidney function in hemorrhagic shock

Cited by 14 publications

References 0 publications

Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Renal Distribution Volumes of Indocyanine Green, [51Cr]EDTA, and 24Na in Man during Acute Renal Failure after Shock. IMPLICATIONS FOR THE PATHOGENESIS OF ANURIA

Lability of renal papillary tissue composition in the rat.

Intrarenal Arterial Patterns in Nonhuman Primates

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