Primary yolk sac tumor of the endometrium: A rare entity

Abhilasha, N; Bafna, U. D.; Pallavi, V. R.; Rathod, PS; Krishnappa, Shobha

doi:10.4103/0019-509x.175315

Cited by 15 publications

(8 citation statements)

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“…In this case, MRI and CE-MRI imaging findings showed bilateral uterine, bladder and vaginal wall invasion, negative bilateral ovary and bilateral fallopian tube involvement is compatible with pathological assessments and extent of invasion determined after surgery. Typical pathology slice image of YST can be expressed as transparent body, papillary and gland-like structure, and the Schiler-Duval (S-D) body is a typical feature (5,6). The tumor cells are arranged in a single layer or a complex layer surrounding the blood vessel.…”

Section: Discussionmentioning

confidence: 99%

Primary Yolk Sac Tumor of the Endometrium with MRI Findings: A Case Report

2020

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: Primary yolk sac tumor (YST) of the endometrium is a very rare malignant germ cell tumor, primary YST of the endometrium with detailed magnetic resonance imaging (MRI) and contrast-enhanced MRI (CE-MRI) findings have not yet been reported in the English literature. We report a 40-year-old woman presenting with irregular lower abdominal pain and dysmenorrhea for more than 5 months. MRI showed a lesion in the right side wall of the uterus. Postoperative pathology and immunohistochemistry confirmed the diagnosis of primary YST of the endometrium with the International Federation of Gynecology and Obstetrics (FIGO) system staging of IV. The signal of the tumor was complex and lacked specific characteristic. Diffusion-weighted imaging (DWI) showed that the lesion is diffuse limited, the average apparent diffusion coefficient (ADC) value of the solid component was 0.735 × 10-3 mm2/s. CE-MRI showed that the irregular lesions presented uneven and mild enhancement in the arterial stage, and continued to strengthen in the venous phase, and strengthened close to the myometrium in the delayed phase. Primary YST of the endometrium should be considered if MRI scans show an irregular lesion in the myometrium with high level of alpha-fetoprotein (AFP).

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Section: Discussionmentioning

confidence: 99%

Primary Yolk Sac Tumor of the Endometrium with MRI Findings: A Case Report

2020

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“…These tumours can aberrantly express CDX2 and form a glandular pattern [17]. In rare case reports of extra-gonadal localization in the uterus, they are described in premenopausal patients and might cause a clear cell pattern with resemblance of clear cell adenocarcinoma of the endometrium [18, 19]. As a hallmark they express immunohistochemically AFP, SALL4 and Glypican3 [17].…”

Section: Discussionmentioning

confidence: 99%

Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report

Trippel¹,

Imboden²,

Papadia³

et al. 2017

Diagn Pathol

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BackgroundIntestinal differentiation of primary mucinous adenocarcinoma of the uterine corpus is exceedingly rare in comparison to the approximately 25% rate in endocervical and ovarian mucinous carcinoma. Additionally, little is known about the related genetic and epigenetic alterations, even though large-scale molecular characterisation of the different types of endometrial cancer took place in the TCGA project along the entities defined by the recent WHO classification.Case presentationWe present a 62-year-old patient harbouring a primary mucinous carcinoma of the uterine corpus with a morphological resemblance to mucinous colorectal adenocarcinoma. The intestinal differentiation was substantiated by CDX2 and CK20 positivity in the absence of PAX8, p16, WT1, p53, ER, PgR, AFP, SALL4 and Glypican3. A high MSI status with MLH1 hypermethylation was revealed by molecular testing.ConclusionIntestinal differentiation of mucinous adenocarcinoma of the endometrium is a unique observation. Besides morphology, it obviously can share molecular features of sporadic MSI colorectal cancers. It can be speculated that either CDX2 positive morula formation or intestinal metaplasia of the endometrium as rare conditions might be the origin of carcinogenesis for this type II endometrial cancer. Both conditions were not detectable in this case. Of note, categorising endometrial cancers in genetic subgroups like MSI high cancers alone might lead to the integration of likewise morphologically different tumours like the case presented here with intestinal differentiation. Hence, careful genotype-phenotype correlations are warranted for studies of mucinous adenocarcinoma of the endometrium.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-017-0629-0) contains supplementary material, which is available to authorized users.

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“…Extragonadal YST occasionally arise from the sacrococcygeal region, mediastinum, retroperitoneum, and the female reproductive tract 1 . Primary yolk sac tumor arising from the uterus is an extremely rare condition, to our best knowledge, only 27 cases have been reported in the English literature (Table 1) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . Here, we present a rare case of extragonadal YST occurring in the uterus of a 2-year-old girl, with a discussion of its clinical management in diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

Yin

Wang

Yang

2022

Journal of Pediatric and Adolescent Gynecology

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Primary yolk sac tumor of the endometrium: A rare entity

Cited by 15 publications

References 0 publications

Primary Yolk Sac Tumor of the Endometrium with MRI Findings: A Case Report

Primary Yolk Sac Tumor of the Endometrium with MRI Findings: A Case Report

Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

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