Primary wound closure in haemophiliacs undergoing dental extractions

Stajčić, Zoran; Baklaja, R; Elezović, Ivo; Rolović, Z

doi:10.1016/s0901-5027(89)80007-4

Cited by 11 publications

(17 citation statements)

References 13 publications

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“…The boy reported by us had received only 9000 IU of factor VIII concentrate when the antibodies were detected. Filling of the socket with collagen and fibrinogen glue and with the packing oversewn might in itself be a procedure to stop the bleeding permanently after a dental extraction in a patient with severe haemophilia (7). In our patient, however, such an extensive local treatment together with tranexamic acid orally was not sufficient for haemostasis.…”

Section: Discussionmentioning

confidence: 71%

Recombinant factor VIIa in an infant with haemophilia A and inhibitors

Tengborn

Kjellman

et al. 1992

Acta Paediatrica

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Post-traumatic bleeding from the gingiva in a 16-month-old boy with severe haemophilia A did not stop after treatment with factor VIII concentrate and tranexamic acid, and it was demonstrated that he had developed antibodies to factor VIII. Treatment with recombinant factor VIIa 60-90 micrograms/kg body weight four to eight times daily, together with local measures, stopped the bleeding and no complications were seen.

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Section: Discussionmentioning

confidence: 71%

Recombinant factor VIIa in an infant with haemophilia A and inhibitors

Tengborn

Kjellman

et al. 1992

Acta Paediatrica

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“…In most studies concerned with dental extractions in PWH, patients with inhibitors were either excluded from the studies or there were no patients with inhibitors in the studies or it is not specified whether they were included at all . The total number of patients with inhibitors throughout all of the reviewed studies remains very small, <25 .…”

Section: Resultsmentioning

confidence: 99%

“…Relatively newer local haemostatic agents, such as Floseal and TachoCom, were used in recent published studies . Most authors advocated wound suturing to approximate the wound edges and reduce trauma from eating chewing forces, and in some studies, primary wound closure that required osteotomy were performed …”

Section: Resultsmentioning

confidence: 99%

“…27,28,30 There are very few studies conducted to compare different local haemostatic modalities. 11,16,27,30,31 Coccero et al 11 has been emphasized by many authors. 9,12,14,16,17,[22][23][24][25]27,30,32,37 Two studies showed that combination of both systemic and local antifibrinolytic use gives favourable results.…”

Section: Local Haemostatic Agents and Measuresmentioning

confidence: 99%

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Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence‐based practice? A review of the literature

Bajkin

Dougall

2020

Haemophilia

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Due to the global prevalence of oral disease, tooth extraction is the most common surgical procedure required in general population thus likely to be similarly common in patients with haemophilia, especially those in older age and those living in countries with restricted resources. There are little or no consensus about optimal level and duration of factor replacement (FRP) therapy required to prevent bleeding complication following surgery and low levels of evidence to inform protocols and guidelines. The goal of this article was to review the literature regarding haematological treatment protocols and to assess their effectiveness in prevention of bleeding complications during and after tooth extractions in people with haemophilia. A total number of 29 articles were identified. Only two of the studies were randomized controlled trials, and meta‐analysis was not possible. Significant heterogeneity regarding haematological regimes, dental surgical procedures, disease severity and sample size of published studies which are unable to reliably inform the provision of safe dental surgery was noted. Based on the haematological regimens, all studies were classified into one of three groups: pre‐ and postoperative FRP or DDAVP, single preoperative FRP or DDAVP, and no FRP treatment. The overall reported bleeding rate in case of both pre‐ and postoperative FRP and single dose FRP preoperative is similar, 11.9% and 11.4%, respectively, indicating that minimizing the use of clotting factor concentrate is possible if proper local haemostatic measures are provided. Strictly designed prospective studies with higher number of patients are necessary to get firm conclusions about optimal FRP treatment required to prevent bleeding complications during and after oral surgery in patients with haemophilia.

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“…The post‐operative application of local pressure and good tissue approximation serve as common non‐pharmacological techniques for the maintenance of hemostasis (191). In one randomized control study, patients on warfarin treatment underwent multiple tooth extractions in which local treatment consisted of placing gelatin sponges in the extraction sites with closure by interrupted resorbable sutures with or without external application of the adhesive n ‐butyl‐2‐cyanoacrylate (Histoacryl™; B. Braun, Melsungen, Germany; Glustitch™; Glustitch Inc, Delta, BC, Canada).…”

Section: Non‐pharmacological Management Of Hemostasismentioning

confidence: 99%

Surgical preparation: anesthesia & hemostasis

Hargreaves¹,

Khan²

2005

Endodontic Topics

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The intra‐operative control of pain and hemorrhage represents significant factors that are required for modern, effective, and efficient endodontic surgical procedures. This review focuses on these important issues and emphasizes the level of clinical evidence of various studies reporting on interventions to alter pain or hemorrhage. To accomplish this goal, the review will provide an overview of the fundamental properties of local anesthetics and hemostasis and then build upon this foundation to provide evidence‐based recommendations for treatment considerations.

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Primary wound closure in haemophiliacs undergoing dental extractions

Cited by 11 publications

References 13 publications

Recombinant factor VIIa in an infant with haemophilia A and inhibitors

Recombinant factor VIIa in an infant with haemophilia A and inhibitors

Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence‐based practice? A review of the literature

Surgical preparation: anesthesia & hemostasis

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