Primary versus secondary IOL implantation following removal of infantile unilateral congenital cataract: outcomes after at least 5 years

Tadros, Dina; Trivedi, Rupal H.; Wilson, M. Edward

doi:10.1016/j.jaapos.2015.10.010

Cited by 18 publications

(14 citation statements)

References 11 publications

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“…Primary or secondary IOL implantation in these children still remains controversial [9] , with many papers supporting both sides of the argument. The rate of primary IOL implantation we observed concerned 76.49% of operated eyes in France between 2010 and 2012, which appears high compared with the British Congenital Cataract Study conducted between 1995 and 1996, finding primary implantation of about 35% [10] .…”

Section: Discussionmentioning

confidence: 99%

Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program

Daïen¹,

Pape

Héve

et al. 2017

Ophthalmic Res

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Introduction: Prevention of visual impairment due to congenital cataract is an international priority as part of VISION 2020 - The Right to Sight, the joint initiative of the World Health Organization and the International Agency for the Prevention of Blindness. The present study is part of the Epidemiology and Safety (EPISAFE) collaborative program aiming at assessing the epidemiology and safety of interventions in ophthalmology. Methods: All children who underwent cataract surgery before the age of 1 year in France between January 2010 and December 2012 were identiﬁed by using the Programme de Médicalisation des Systèmes d'Information. Results: In 3 years, 532 children (699 eyes; 46.6% girls) had cataract surgery before the age of 1 year; 31.4% had bilateral surgery. During the first year of life, the incidence of cataract surgery was 2.15/10,000 births. The median (interquartile range) age at surgery was 3.5 (2.2-4.8) months for children with unilateral cataract and 4.0 (2.2-7.2) months for children with bilateral cataract. Of the 699 operated eyes, 76.49% received intraocular lens implantation during the cataract surgery. Conclusions: The incidence of congenital cataract surgery observed in France is close to that in the literature in the industrialized world, which is estimated at 1-3/10,000 births. The timing of surgery is critical for visual development. Surgery was performed younger in children with monocular cataracts than in those with bilateral cataracts.

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Section: Discussionmentioning

confidence: 99%

Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program

Daïen¹,

Pape

Héve

et al. 2017

Ophthalmic Res

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“…The outcome measure was defined as the long-term secondary glaucoma rate, which means glaucoma developed at least one year after cataract surgery. The diagnosis criteria of secondary glaucoma from included studies varies, most of which made the diagnosis by elevated IOP (over 21mmHg) in 2 to 3 random tests plus one or more of the following combination signs: (1) optic disc cupping �0.3/ asymmetry �0.2/progression, (2)corneal changes, (3)progressive myopia shift [11][12][13][14][15][16][17], while the other study diagnosed glaucoma only if the patients with elevated IOP tested 2 to 3 times randomly [18]. If there was more than one published report on the same population or group of patients, the most recent results with complementary data from previous articles were used for the statistical analysis.…”

Section: Outcome Measuresmentioning

confidence: 99%

The role of primary intraocular lens implantation in the risk of secondary glaucoma following congenital cataract surgery: A systematic review and meta-analysis

Zhang

Wang

et al. 2019

PLoS ONE

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This meta-analysis aims to evaluate the incidence of secondary glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation. Methods An electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or secondary IOL implantation followed by receiving extraction surgery were included in this study. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. Long-term incidences of secondary glaucoma, which developed at least one year after cataract surgery, were considered and discussed as clinical outcomes in each cohort. The pooled data were analyzed according to a random effects model. Results Eight publications involving 892 eyes were included in the current meta-analysis. In the general population of eyes with congenital cataract, the long-term incidence of secondary glaucoma was lower (P = 0.06) in eyes with primary IOL (9.5%) than in eyes without primary IOL (15.1%), including aphakia and secondary IOL. The pooled risk ratio (RR) favors primary IOL implantation in all patients (RR = 0.63). For bilateral congenital cataract, the incidence was 6.7% in eyes with primary IOL implantation, which is significantly lower than the 16.7%

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“…Primary IOL implantation is a standard procedure for patients older than two years of age. In terms of unilateral cataracts, primary IOL implantation is suggested to be carried out in patients over 1 year old (Tadros et al, ). IOL implantation in children less than 6 months old, particularly in bilateral cataracts, is still considered high risk due to severe postoperative inflammation, posterior capsule opacification (PCO), and other complications (Vasavada and Vasavada, ).…”

Section: Cataract Surgery and Concernsmentioning

confidence: 99%

Screening, genetics, risk factors, and treatment of neonatal cataracts

Xia

Wang

et al. 2017

Birth Defects Research

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Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topics requiring further study in both clinical cataract therapy and basic lens research. Advances in genetic screening and surgical technologies have improved the diagnosis, management, and visual outcomes of affected children. For example, mutations in lens crystallins and membrane/cytoskeletal components that commonly underlie genetically inherited cataracts are now known. However, many questions still remain regarding the causes, progression, and pathology of neonatal cataracts. Further investigations are also required to improve diagnostic criteria for determining the timing of appropriate interventions, such as the implantation of intraocular lenses and postoperative management strategies, to ensure safety and predictable visual outcomes for children. Birth Defects Research 109:734-743, 2017. © 2017 Wiley Periodicals, Inc.

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Primary versus secondary IOL implantation following removal of infantile unilateral congenital cataract: outcomes after at least 5 years

Cited by 18 publications

References 11 publications

Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program

Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program

The role of primary intraocular lens implantation in the risk of secondary glaucoma following congenital cataract surgery: A systematic review and meta-analysis

Screening, genetics, risk factors, and treatment of neonatal cataracts

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