Primary vaginal leiomyosarcoma in pregnancy☆

Behzatoğlu, Kemal; Bahadir, Burak; İnhan, Gülcan; Altuğ, Mebrure

doi:10.1016/j.ygyno.2003.08.031

Cited by 12 publications

(7 citation statements)

References 8 publications

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“…About 71 cases have been reported in the English literature so far. [2356789] The rarity of these tumors has contributed to the paucity of information regarding the clinical features, mode of management and prognosis of patients. Most patients with vaginal leiomyosarcoma present with an asymptomatic vaginal mass, but may also experience vaginal, rectal or bladder pain, vaginal discharge or bleeding, difficulty in micturition or, rarely, dyspareunia.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the vagina: A rare entity with comprehensive review of the literature

Khosla

Patel

Kumar

et al. 2014

Int J App Basic Med Res

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Primary malignant lesions of the vagina are uncommon, and vaginal sarcomas are even rarer. We describe a rare case of stage I, high-grade leiomyosarcoma of the vagina treated with combined modality treatment. A 39-year-old female presented with vaginal mass and underwent resection. Histopathological examination revealed atypical leiomyoma of the vagina with definite risk of recurrence. Eleven months later, she presented with a recurrent vaginal mass and underwent exploratory laparotomy with total abdominal hysterectomy and bilateral salpingo-oophorectomy plus resection of recurrent tumor and partial vaginectomy. The detailed histopathological examination was suggestive of leiomyosarcoma of the vagina. The patient received adjuvant radiotherapy and chemotherapy. The patient is alive and disease-free 29 months postsurgery. Experience with vaginal leiomyosarcomas is limited. The optimal treatment methods have not yet been established because of the rarity of the tumor. We add another case of leiomyosarcoma of the vagina to the limited existing literature.

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Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the vagina: A rare entity with comprehensive review of the literature

Khosla

Patel

Kumar

et al. 2014

Int J App Basic Med Res

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“…El síntoma más común es el sangrado genital tal y como aparece en nuestro caso. (8) El diagnóstico del leiomiosarcoma durante el embarazo requiere una correcta evaluación anatomopatológica dado que la propia gestación induce cambios histológicos tales como hemorragia, necrosis y cambios degenerativos. (9,10) En concreto en este caso, los criterios anatomopatológicos son: células fusiformes con atipia moderada focalmente severa, mitosis, algunas atípicas, alcanzando hasta 11 mitosis/10 CGA, la presencia de necrosis y el borde de la lesión focalmente infiltrativo.…”

Section: Discussionunclassified

“…El tratamiento primario consiste en la exéresis quirúrgica de la lesión con márgenes adecuados. (8) La baja prevalencia de estos tumores dificulta el poder establecer un correcto manejo y tratamiento, así como establecer adecuadamente un pronóstico. De hecho, la literatura que se encuentra al respecto consiste principalmente en unos escasos casos clínicos o pequeñas series de casos.…”

Section: (Imágenes 2 Y 3: Estudio Anatomopatológico)unclassified

Leiomiosarcoma primario vaginal en el embarazo. A propósito de un caso

Romero

Rangel

Bayo

et al. 2018

Rev. chil. obstet. ginecol.

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RESUMENLos sarcomas primarios de vagina son extremadamente raros especialmente durante la gestación. Se presenta el caso de una gestante de 25+2 semanas que acude a urgencias con clínica de sangrado vaginal objetivándose a la exploración una formación nodular dependiente de pared vaginal derecha. Dada la clínica se reseca en quirófano con el hallazgo histopatológico de leiomiosarcoma. A la gestante se le realiza sin incidencias una cesárea en la semana 34 de gestación, previa maduración pulmonar fetal, completándose en el puerperio inmediato el estudio de extensión sin encontrarse ningún hallazgo relevante. Finalmente, se somete a la paciente a una histerectomía y salpinguectomía bilateral con preservación ovárica. El seguimiento y los controles sucesivos de la gestante en los meses posteriores muestran ausencia de enfermedad. ABSTRACTPrimary sarcomas of the vagina are extremely rare, especially during pregnancy. We report a case of a 25-weekpregnant who came to emergency room complaining of vaginal bleeding. Pelvic examination revealed a globular mass located on the right vaginal wall. Given the persistent bleeding, resection of the mass was performed. The specimen was sent to pathology and confirmed to be a leiomyosarcoma. At 34-weeks of pregnancy after fetal lung maturation a cesarean section is done. It was completed the extension study during immediate postpartum without any relevant finding. Finally, she had a totally hysterectomy and bilateral salpingectomy with ovarian preservation. Clinical follow-up over the following months shows no evidence of disease.

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“…We searched the literature in detail in an attempt to uncover other cases published in both English and languages other than English before 2000 and have found 65 additional cases (7–16) . Further search for cases published since 2000 disclosed five additional cases (17–20) . Together with our case detailed above, the total number of cases to date is 138.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of the vagina: case report and literature review

Ahram¹,

Lemus²,

Schiavello³

2006

Int J Gynecol Cancer

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Leiomyosarcoma of the vagina is quite rare. Extensive search of the literature discloses 137 case reports published over the past 40 years. Collectively, these reports give only cursory guidelines for diagnosis, management, and prognosis. We add another case to the sparse literature on leiomyosarcoma of the vagina. Treatment consisted of surgical excision. Tumor was found to extend to the margin of the excised specimen. The malignancy quickly recurred with lung metastases and the patient died. The very poor prognosis associated with this lesion emphasizes the critical need for early diagnosis and expeditious therapy. In the interest of improving salvage by prompt recognition and intervention, it is important for health-care professionals to be knowledgeable about and alert to this condition.

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Primary vaginal leiomyosarcoma in pregnancy☆

Cited by 12 publications

References 8 publications

Leiomyosarcoma of the vagina: A rare entity with comprehensive review of the literature

Leiomyosarcoma of the vagina: A rare entity with comprehensive review of the literature

Leiomiosarcoma primario vaginal en el embarazo. A propósito de un caso

Leiomyosarcoma of the vagina: case report and literature review

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