Primary uterine lymphoma: Report of 2 cases and review of literature

Hariprasad, Roopa; Kumar, Lalit; Bhatla, D.M. Neerja; Kukreja, Manu; Papaiah, Shridhar

doi:10.1016/j.ajog.2006.04.002

Cited by 32 publications

(39 citation statements)

References 25 publications

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“…Previous reports indicate that the cervical site is predominantly involved, with 75% of primary ML occurring in the female genital tract;1, 2, 3, 9 however, cervical ML is rare and represents < 0.01% of all cervical tumors 4, 10, 11…”

Section: Discussionmentioning

confidence: 99%

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Kasai

Ichimura

Murakami

et al. 2015

J of Obstet and Gynaecol

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The incidence of primary malignant lymphoma arising in the female genital tract is extremely rare and constitutes approximately 0.05% of malignant tumors. Uterine malignant lymphoma develops in the endometrial stroma, causing minimal necrosis. It is therefore difficult to diagnose malignant lymphoma, as it does not involve genital bleeding or epithelial defects. We have performed transcervical needle biopsies from deep in the myometrium, with the purpose of diagnosing uterine muscle layer lesions, such as leiomyosarcoma, but this is an unusual method. In this report, we suggest that transcervical needle biopsy is useful in the diagnosis of uterine malignant lymphoma.

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Section: Discussionmentioning

confidence: 99%

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Kasai

Ichimura

Murakami

et al. 2015

J of Obstet and Gynaecol

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“…The natural history of NHL of the cervix varies with histological types. The most common histological subtype is diffuse large B-cell lymphoma [3,10,19]. Reviewing the cases reported in the literature, the follicular subgroup comprises only 8.5% of the primary cervix NHL cases.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies suggest that management with combination of chemotherapy and after pelvic radiotherapy apparently is the best option with better survival and a 5-year survival rate of up to 100% in some series of primary NHL of the cervix [3,6,10,16,18,19,29,36,37]. Reviewing the literature, 36 patients received combination treatment of chemotherapy and external radiotherapy, and only two of them died of disease at the second and ninth month after diagnosis (Table 1) [3,6,9,10,13,16,18,19,22,25,27,[30][31][32][33][34][36][37][38][39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

“…To preserve reproductive function in such young patients and/or to prevent the micrometastasis, combination chemotherapy alone was advocated [14][15][16]21]. If involved field radiotherapy (IF-XRT) alone is to be applied in young patients, then ovarian transposition to preserve reproductive and gonadal function shall be considered [10].…”

Section: Discussionmentioning

confidence: 99%

“…In the cervical lymphoma, the median age at presentation is 44 years, ranging from 27 to 80 years [5,10]. The most frequent complaint is abnormal vaginal bleeding [7].…”

Section: Introductionmentioning

confidence: 99%

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Primary follicular lymphoma of the cervix uteri: a review

et al. 2007

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Primary non-Hodgkin's lymphoma of the cervix is a rare disease, of which a subgroup of follicular lymphoma constitutes only 8.5%. There is not an established treatment protocol neither for primary cervical lymphoma nor for its follicular subgroup. We presented a case with Ann Arbor stage IEA (Extra-nodal involvement and absence of weight loss, fever, night sweat) primary follicular lymphoma of the cervix. She was treated with chemotherapy followed by pelvic radiotherapy. Upon relapse with a nodal neck mass, she was treated with rituximab alone. She remained well for 23 months after rituximab. In the 39 months of follow-up, there was no evidence of disease. In the light of our case, we reviewed the reported cases of primary follicular lymphoma of the cervix while discussing their treatment protocols and the cases of primary cervix lymphoma treated with rituximab.

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Hematologic malignancies of the female genital tract diagnosed on liquid‐based Pap test: Cytomorphologic features and review of differential diagnoses

Hanley

Tadros

Briones

et al. 2008

Diagnostic Cytopathology

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The female genital tract is rarely the primary site for hematologic malignancies; however, secondary involvement of this anatomic site is common. Primary lymphomas of the gynecologic tract are reported to represent less than 1% of extranodal non-Hodgkin lymphomas (NHL), and the majority of them being B-cell in origin. Diffuse large B-cell lymphoma is the most common subtype, whereas primary extraosseus plasmacytoma of the genital tract is rare.If clinically not suspected, these rare tumors pose a diagnostic challenge both for clinicians and pathologists. Clinical symptoms are often nonspecific and mimic other more common gynecologic malignancies such as squamous cell carcinoma of the cervix or endometrial adenocarcinoma. Although cervico-vaginal (Pap) smear is the primary screening method for cervical squamous cell carcinoma and its precursors, it is far less sensitive for detection of other primary or metastatic malignancies. In this review, we present three cases of hematologic gynecologic malignancies, two cases of primary NHL, and a case of acute myeloid leukemia with relapse as a pelvic mass, all of which were diagnosed on a liquidbased Pap test. In addition, we discuss the morphologic features of differential diagnostic entities of these rare tumors on conventional and liquid-based preparations.

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Primary uterine lymphoma: Report of 2 cases and review of literature

Cited by 32 publications

References 25 publications

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Primary follicular lymphoma of the cervix uteri: a review

Hematologic malignancies of the female genital tract diagnosed on liquid‐based Pap test: Cytomorphologic features and review of differential diagnoses

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