Primary undifferentiated sarcoma of the meninges: A case report and comprehensive review of the literature

Wapshott, Taylor; Schammel, Christine; Schammel, David P.; Rezeanu, Luminita; Lynn, Michael

doi:10.1016/j.jocn.2018.04.060

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Postoperative chemotherapy and/or radiation have been reported in cases, but there remains no histopathological or molecular framework in which to guide adjuvant therapy [10,11]. Most recently, Wapshott et al provided a comprehensive review of the literature of intracranial UPS detailing the clinical characteristics and management of reported patients but concluded a lack of molecular characterization of this disease entity to guide clinical prognostication and targeted therapies [4].…”

Section: Discussionmentioning

confidence: 99%

“…[2] Compared to systemic UPS, intracranial UPS has a worse prognosis with a mean overall survival of 1-2 years, which is perhaps even poorer in secondary UPS from prior radiation. [3,4] e literature surrounding intracranial UPS, either arising primary or secondary to prior radiation, is limited to individual reports, detailing the clinical management of this rare but challenging disease entity. [4] However, to date, no studies have reported genetic or molecular characteristics of intracranial UPS.…”

Section: Introductionmentioning

confidence: 99%

“…[3,4] e literature surrounding intracranial UPS, either arising primary or secondary to prior radiation, is limited to individual reports, detailing the clinical management of this rare but challenging disease entity. [4] However, to date, no studies have reported genetic or molecular characteristics of intracranial UPS. In this study, we present genomic data from a case of radiation-induced intracranial UPS and discuss the pertinent findings that define the molecular signatures of this lesion.…”

Section: Introductionmentioning

confidence: 99%

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Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

Hong

Partovi

Clune

et al. 2021

Case Reports in Genetics

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Intracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. Furthermore, there is a lack of genetic or molecular characterization to guide potential for targeted therapies. We present genomic analysis of a radiation-induced intracranial undifferentiated pleomorphic sarcoma in an 83-year-old woman with notable KIT and PDGFRA alterations. Further similar genomic studies of intracranial pleomorphic sarcoma are needed to develop better therapies for this rare but challenging disease entity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

Hong

Partovi

Clune

et al. 2021

Case Reports in Genetics

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“…Typically, they are asymptomatic and their finding is incidental; if symptomatic they usually present with headache, hemiparesis, or seizures [11].…”

Section: Introductionmentioning

confidence: 99%

Meningosarcoma in The Infratemporal Fossa: An Unusual Presentation

Guido¹,

Flavia²,

Linda³

et al. 2022

Neurosurg Cases Rev

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Background: Meningosarcoma represent a rare disease with an uncertain prognosis. Moreover, localization of tumours in the infratemporal fossa is rare. Lack of associated symptomatology of infratemporal fossa's lesions could result in a diagnosis and treatment delay. Also, surgical management of infratemporal fossa neoplasm remain challenging. Case presentation:The authors present the case of a meningosarcoma extended to the infratemporal fossa, which presented in an advanced stage and required other treatment further than surgery. Conclusion:A comprehensive histological evaluation and a multidisciplinary team help making the diagnosis and managing all eventualities. Sometimes surgery is not enough, and more therapeutic strategies are necessary.

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Nonmeningothelial Dural-Based Lesions: A Histopathological Analysis

Gajaria,

Shenoy,

Goel

2023

Asian J Neurosurg

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Introduction We report 30 cases of nonmeningothelial dural-based lesions encountered during a 3-year study period. Materials and Methods We retrospectively reviewed pathology records of patients operated for extra-axial, dural-based lesions during the years 2016 to 2018 and included nonmeningothelial lesions as a part of this study. Results Among the 3,243 neurosurgical specimens for histopathologic examination, only 30 (0.93%) were “nonmeningothelial dural-based lesions.” Six (20%) patients were in the pediatric age group. Pathologic assessment identified 13 cases of solitary fibrous tumor/hemangiopericytoma (43.3%) and 7 cases of Ewing's sarcoma/primitive neuroectodermal tumor (23.3%). Two cases (6.7%) were of metastasis. Other lesions included a single case each of non-Hodgkin's lymphoma, undifferentiated sarcoma, solitary plasmacytoma, and granulocytic sarcoma. Nonneoplastic lesions included two cases each of Rosai–Dorfman disease and nonspecific inflammatory lesions. Conclusion Nonmeningothelial dural-based lesions being rare, thorough examination of morphological features is a must by the pathologist, to arrive at the accurate diagnosis. Ancillary tests, if required, should be employed in the context of the morphologic picture.

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Primary undifferentiated sarcoma of the meninges: A case report and comprehensive review of the literature

Cited by 3 publications

References 46 publications

Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

Meningosarcoma in The Infratemporal Fossa: An Unusual Presentation

Nonmeningothelial Dural-Based Lesions: A Histopathological Analysis

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