Primary Tumors and Pseudotumors of the Heart*

Abbott, Osler A.; Warshawski, Frances E.; Cobbs, Woodfin B.

doi:10.1097/00000658-196215560-00005

Cited by 10 publications

(14 citation statements)

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“…In one case of sarcoma local resection and nitrogen-mustard therapy result in temporary benefit (Abbott et al, 1962). In our case radiotherapy appeared to have no effect whatever on the inexorable course of the disease.…”

Section: Medical Memorandacontrasting

confidence: 42%

Allergic Pericarditis

Clarkson¹,

Kb²,

Fleischl³

1964

BMJ

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Section: Medical Memorandacontrasting

confidence: 42%

Allergic Pericarditis

Clarkson¹,

Kb²,

Fleischl³

1964

BMJ

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“…Comments on the loudness of the first heart sound in left atrial myxoma2 [9][10][11][12][13][14][15][16] have been made in several case reports but in others, although illustrated, the phenomenon seems to have been overlooked. Various explantations have been offered as to the cause of the loud Si in this condition: there may be more forceful closure of the mitral valve'0 and the loudness of S1 may be due to tumour movement9-" produced either through the checking of the myxoma by its stalk '2 or by it striking the atrial wall and mitral valve.12-'4 Furthermore a high left atrial pressure alone may be responsible.…”

Section: Resultsmentioning

confidence: 99%

The loud first heart sound in left atrial myxoma.

Gershlick¹,

Leech²,

Mills³

et al. 1984

Heart

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The interrelation between the loudness of the first heart sound, the time interval from the Q wave to the onset of the first heart sound (QM1), and the mitral valve closure rate was studied in nine patients presenting with left atrial myxomata. In seven patients the first heart sound was loud preoperatively and was associated with delayed mitral valve closure. After removal of the myxoma the onset of mitral valve closure returned towards normal, the mitral valve closure rate was reduced, and the first heart sound became softer. In two patients the first heart sound was normal before and after operation as were both the time of onset of mitral valve closure and the mitral valve closure rate. In neither of these patients did the myxoma completely fill the mitral orifice during diastole. The loud first heart sound in left atrial myxoma is a useful clinical sign, and intensity is directly related to the delay in onset of closure of mitral leaflets.

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“…The diastolic filling sound, the so-called "tumour plop," occurs earlier in diastole than the usual third heart sound, near the timing of the opening snap of the mitral valve with which it is sometimes confused (Greenwood, 1968;Abbott et al, 1962;Pi-tt et al, 1965). This early diastolic sound is thought to be produced by the sudden deceleration of the tumour on its pedicle as it enters the left ventricle (Pitt et al, 1965).…”

Section: Commentmentioning

confidence: 99%

Mitral regurgitation due to rupture of chordae tendineae by calcified atrial myxoma.

Wise¹

1974

BMJ

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DiscussionThese results show that AH 7725 when given by mouth can inhibit the immediate bronchial response to inhaled antigen in asthmatic patients. It has no bronchodilator effect (Gayrard, 1974) and its activi.ty is most likely to be explained by the inhibition of release of mediators of immediate-type allergic responses, which has already been shown in laboratory work.AH 7725 has similar inhibitory properties to those of disodium cromoglycate and also to those of its own predecessors AH 6556 and AH 7079 (Assem, 1973; Assem and McAllen, 1973 b). It is, however, exceptional in being active when given by mouth. So far as we know this is the first report on a d1rug for the prophylaxis of asthma which is active when given by mouth.Our Journal, 1974, 2, 95-96 Patienits with left atrial myxoma characteristically present with a history of progressive shortness of breath, often punctuated by syncopal attacks, and physical signs of miitral valve obstruction (Goodwin, 1963;Greenwood, 1968; Harvey, 1968). Predominant or "pure" mitral regurgitation due to left atrial myxoma has been reported but is uncommon (Cohen et al., 1963;Penny et al., 1967;Wittenstein et al., 1959). This report describes a patient with a calcified left atrial myxoma who presented with sudden severe mitral regurgitation due to ruptured chordae tendineae.Case Report A 44-year-old machinist, previously well and active, abruptly developed dyspnoea and orthopnoea during the first week of December 1972. He was admitted to his local hospital where he was found to have cardiac enlargement, pulmonary oedema, and bilateral pleural effusion. The electrocardiogram showed sinus rhythm with evidence of left atrial enlargement. A heart murmur had been heard one year earlier, but he was told "not to worry" about his heart. There was no history of rheumatic fever, chest pain, calf tendemess or swelling, or fever or chills. Digitalis (digoxin 0-25 mg/day) and a diuretic (Lasix Cardiology Section, Medical Service, Eastern Maine Medical Center, Bangor, Maine, 0441, U.S.A. JOE R. WISE, juN., M.D., Attending Physician 40 mg/day) were given but dyspnoea, orthopnoea, and fatigue persisted, atrial fibrillation developed, and he was referred for consultation.On examination he was very thin and dyspnoeic at rest. Atrial fibrillation was present, the blood pressure was 110/60 mm Hg, there were no signs of peripheral embolism, and the optic fundi were normal. The carotid pulse was small and rapid, the venous pressure was raised, and there was prominent systolic pulsation of the neck veins. The apex beat was in the mid-clavicular line and there was a prominent, diffuse systolic pulsation in the third to fifth interspaces midway between the sternum and the apex. The pulmonary valve closure sound was increased and the aortic component normal. A loud first heart sound was followed by a grade III/VI regurgitant murmur heard best at the apex. There was a prominent early third heart sound and a faint mid-diastolic apical murmur. The lungs were clear. The liver was palpable 2 cm b...

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Primary Tumors and Pseudotumors of the Heart*

Cited by 10 publications

References 0 publications

Allergic Pericarditis

Allergic Pericarditis

The loud first heart sound in left atrial myxoma.

Mitral regurgitation due to rupture of chordae tendineae by calcified atrial myxoma.

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