Primary tubulovillous adenocarcinoma of the upper urinary tract: A rare non-urothelial neoplasm

Primary adenocarcinoma of the renal pelvis in spina bifida patient with history of simple cystectomy

“…Those with urinary diversions may be at higher risk for renal adenocarcinoma, as urinary infections are potential long-term complications in this population, though correlative analyses investigating this hypothesis do not currently exist. 10 …”

“… Study Patient Data and Significant History Tumor Characteristics Management Outcome Xiong et al (2016) 2 55-year-old male + hematuria + flank pain Pathological examination: moderately differentiated adenocarcinoma of the renal pelvis, ureter, and urinary bladder Right radical nephrectomy, ureterectomy, radical cystectomy and left ureterocutaneostomy No evidence of tumor recurrence at 6-month follow-up Lai et al (2016) 3 40-year-old male + flank pain Pathological examination: primary enteric-type mucinous adenocarcinoma of the renal pelvisCEA: 31.4 ng/ml (Normal: 25 ng/ml) Right radical nephrectomy CEA returned to normal range by 1-month follow-upNo evidence of tumor recurrence at 14- month follow-up Agrawal et al (2021) 5 60-year-old male + flank pain + hx of renal calculi Pathological examination: grossly dilated pelvicalyceal system filled with gelatinous material and multiple brownish papillary nodulesFinal pathological stage: pT3aNx primary mucinous adenocarcinoma of the renal pelvis Open right radical nephrectomy No evidence of tumor recurrence at 18-month follow-up Abbas et al (2014) 6 56-year-old male + flank pain Histological examination: tumor with cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei and vacuolated cytoplasm. Mucin pools with scattered poorly differentiated signet ring tumor cells were seen infiltrating into the renal cortexFinal pathological stage: pT3pN0 primary mucinous adenocarcinoma of the renal pelvis with in-situ adenocarcinoma of the ureter Nephrectomy with partial ureterectomy Metastasis involving the chest wall at 6-month follow-up Gupta et al (2020) 10 51-year-old male + hx of renal calculi Histopathological evaluation: well-differentiated tubular adenocarcinoma enteric type with muscularis involvementFinal pathological stage: pT2N0Mx papillary urothelial carcinoma with villoglandular differentiation Robot-assisted laparoscopic radical nephroureterectomy, with bladder cuff excision and regional lymphadenectomy. No evidence of tumor recurrence at 3-month follow-up Ho et al (2008) 8 …”