Primary tuberculosis of the oral cavity

Dimitrakopoulos, Ioannis; Zouloumis, Lambros; Lazaridis, Nikolaos; Karakasis, D.; Trigonidis, G; Sichletidis, Lazaros

doi:10.1016/0030-4220(91)90017-7

Cited by 72 publications

(47 citation statements)

References 7 publications

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“…24,25 Consumption of infected milk is thought to be an important source of infection of the oral cavity; minute trauma of the mucosa invites seeding of the bacilli. 12 …”

Section: Mode Of Infectionmentioning

confidence: 99%

Tuberculosis in the head and neck: experience in India

et al. 2007

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Objective: With improvement in economic and social conditions and the use of effective anti-tubercular therapy, the developed nations, and most developing nations, have enjoyed a decline in tuberculosis for several decades. It is now seen that extra-pulmonary presentations form a major proportion of new cases, especially since the advent of the acquired immunodeficiency syndrome epidemic. Therefore, it is important that otolaryngologists are aware of tuberculosis in the head and neck region and its varied manifestations. We report the increased incidence of isolated head and neck tuberculosis, its various presentations and clinical manifestations over a 10-year period.Materials and methods: A 10-year (1995 -2004), retrospective study was undertaken by the department of otolaryngology and head and neck surgery, Kasturba Medical College, and its allied hospitals, Mangalore, South India, involving a group of 165 patients with head and neck tuberculosis. Each patient underwent a detailed clinical examination and a battery of investigations. Most patients were treated with anti-tubercular therapy alone; others required surgical intervention followed by Antitubercular therapy (ATT). In addition, those with human immunodeficiency virus infection or malignancy were treated with anti-retroviral therapy and radiotherapy, respectively.Results: Of the 165 cases, 121 (73.3 per cent) had isolated tubercular lymphadenitis, 24 (14.5 per cent) had laryngeal tuberculosis, four (2.4 per cent) had tubercular otitis media, three (1.8 per cent) had tuberculosis of the cervical spine, three (1.8 per cent) had tuberculosis of the parotid, eight (5 per cent) had tuberculosis of the oral cavity, one had tuberculosis of the temporo-mandibular joint and one had tuberculosis of the nose. Fine needle aspiration cytology was highly effective in the diagnosis of tubercular lymphadenitis (92 per cent) but not so for other sites. The purified protein derivative (PPD) test was positive in only 20 per cent of cases. Pus for culture and sensitivity was positive only in caries of the spine and mandibular tuberculosis. Excision biopsy and histopathological examination were required to make a diagnosis in tuberculosis of the oral and nasal cavities, salivary glands, ear, temporo-mandibular joint, and mandible. There were 40 cases (24.2 per cent) with coexisting pulmonary tuberculosis and five cases (3 per cent) with coexisting malignancy. Of the 65 patients who were tested, 30 per cent were found to have coexisting human immunodeficiency virus infection.Conclusion: In addition to cervical lymphadenitis, tuberculosis in the head and neck region can produce isolated disease in the oral cavity, ear, salivary glands, temporo-mandibular joint, nose and larynx. Seventy-five per cent of our head and neck tuberculosis patients did not have pulmonary involvement. Fine needle aspiration cytology was highly effective in the diagnosis of nodal tuberculosis, but histopathological examination was required to make the diagnosis in other head and neck sites. ...

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“…24,25 Consumption of infected milk is thought to be an important source of infection of the oral cavity; minute trauma of the mucosa invites seeding of the bacilli. 12 …”

Section: Mode Of Infectionmentioning

confidence: 99%

Tuberculosis in the head and neck: experience in India

et al. 2007

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“…The typical presentation is that of a single indurated painful ulcer with irregular borders covered by inflammatory exudates, but atypical cases with multiple lesions or asymptomatic ulcers have also been described [12]. Dimitrakopoulos et al [14] reported two cases of primary oral tuberculosis that presented with painless ulceration of long duration and enlargement of the regional lymph nodes. In the present case, patient presented with painless ulcer having rolled edges and indurated white base at the mucosa of corner of mouth extending towards cheek.…”

Section: Case Reportmentioning

confidence: 99%

Tubercular Ulcer: Mimicking Squamous Cell Carcinoma of Buccal Mucosa

Ram

Kumar

Mehrotra

et al. 2011

J. Maxillofac. Oral Surg.

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“…These patients develop disease as a result of direct implantation of tubercle bacilli from the sputum into the damaged mucosa with the help of predisposing factors (2). Although it is rare, cases with primary tuberculosis of the oral cavity have been reported (8). As it was the case in our patient, bacillemia which develops less frequently during the primary infection evoked on first exposure to tubercle bacilli and mycobacteria that can spread throughout the body can be controlled by host cellular immunity, however it rarely results in primary tuberculosis of the tongue with activation of bacilli since this response is usually inadequate for sterilization.…”

Section: Discussionmentioning

confidence: 99%

A case report of primary tuberculosis of the tongue

et al. 2017

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At present, the rate of extrapulmonary tuberculosis is gradually increasing among all tuberculosis cases. The secondary tuberculosis of oral cavity represents 0.2-1.5% of all cases with extrapulmonary tuberculosis. Although incidence of oral lesions secondary to pulmonary tuberculosis ranges from 0.4% to 1.5%, primary tuberculosis of the tongue occurs very rare, and it is published only as isolated case reports. A male patient presented to our dermatology clinic with complaints of painful ulcerated white plaques on the tip of his tongue lasting for three months, and an excisional biopsy showed granulomatous inflammation with caseification necrosis. Pulmonary and systemic examination showed no evidence of pulmonary or other extra-pulmonary tuberculosis, and he was initiated therapy for diagnosis of primary tuberculosis of the tongue. We found that the lesion completely resolved during the follow up visit after 1 month. Primary tuberculosis of the tongue should be for differential diagnosis of resistant painful oral lesions.

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Primary tuberculosis of the oral cavity

Cited by 72 publications

References 7 publications

Tuberculosis in the head and neck: experience in India

Tuberculosis in the head and neck: experience in India

Tubercular Ulcer: Mimicking Squamous Cell Carcinoma of Buccal Mucosa

A case report of primary tuberculosis of the tongue

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