Primary Transpupillary Thermotherapy for Choroidal Melanoma in 391 Cases

Mashayekhi, Arman; Shields, Carol L.; Rishi, Pukhraj; Atalay, Hatice Tuba; Pellegrini, Marco; McLaughlin, John P.; Patrick, Kaitlin; Morton, Spenser J.; Remmer, Meredith H.; Parendo, Anthony; Schlitt, Meghan A.; Shields, Jerry A.

doi:10.1016/j.ophtha.2014.09.029

Cited by 70 publications

(61 citation statements)

References 38 publications

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“…69 The percentage recurrence at 10 years by Kaplan-Meier estimate was 18% with 1 or 2 risk factors, 35% with 3 to 5 risk factors, and 55% with 46 risk factors. 69 Thus, TTT is less preferable in cases with multiple risk factors.…”

Section: Transpupillary Thermotherapymentioning

confidence: 91%

“…68,69 A direct correlation is found between tumor recurrence and the number of risk factors predictive of tumor growth (TFSOM UHHD). 69 The percentage recurrence at 10 years by Kaplan-Meier estimate was 18% with 1 or 2 risk factors, 35% with 3 to 5 risk factors, and 55% with 46 risk factors. 69 Thus, TTT is less preferable in cases with multiple risk factors.…”

Section: Transpupillary Thermotherapymentioning

confidence: 99%

“…Complications include retinal traction (44%), branch retinal vein occlusion (26-41%), branch retinal artery occlusion (12%), cystoid macular edema (9-23%), macular epiretinal membrane (23%), vitreous hemorrhage (10%), retinal neovascularization (6%), foveal traction (4%), chorioretinal scar at fovea (4%), tractional retinal detachment (2%), optic disc atrophy (2%), rhegmatogenous retinal detachment (1%), and transient serous retinal detachment (1%), optic disc edema (o1%), and cataract (o1%). 68,69 Tumor recurrence following TTT for choroidal melanoma is 9-28% of cases. 68,69 A direct correlation is found between tumor recurrence and the number of risk factors predictive of tumor growth (TFSOM UHHD).…”

Section: Transpupillary Thermotherapymentioning

confidence: 99%

“…68,69 Tumor recurrence following TTT for choroidal melanoma is 9-28% of cases. 68,69 A direct correlation is found between tumor recurrence and the number of risk factors predictive of tumor growth (TFSOM UHHD). 69 The percentage recurrence at 10 years by Kaplan-Meier estimate was 18% with 1 or 2 risk factors, 35% with 3 to 5 risk factors, and 55% with 46 risk factors.…”

Section: Transpupillary Thermotherapymentioning

confidence: 99%

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Uveal melanoma: relatively rare but deadly cancer

Kaliki

Shields

2016

Eye

468

533

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Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation. Currently, the most widely used first-line treatment options for this malignancy are resection, radiation therapy, and enucleation. There are two main types of radiation therapy: plaque brachytherapy (iodine-125, ruthenium-106, or palladium-103, or cobalt-60) and teletherapy (proton beam, helium ion, or stereotactic radiosurgery using cyber knife, gamma knife, or linear accelerator). The alternative to radiation is enucleation. Although these therapies achieve satisfactory local disease control, long-term survival rate for patients with uveal melanoma remains guarded, with risk for liver metastasis. There have been advances in early diagnosis over the past few years, and with the hope survival rates could improve as smaller tumors are treated. As in many other cancer indications, both early detection and early treatment could be critical for a positive long-term survival outcome in uveal melanoma. These observations call attention to an unmet medical need for the early treatment of small melanocytic lesions or small melanomas in the eye to achieve local disease control and vision preservation with the possibility to prevent metastases and improve overall patient survival.

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Section: Transpupillary Thermotherapymentioning

confidence: 91%

Section: Transpupillary Thermotherapymentioning

confidence: 99%

Section: Transpupillary Thermotherapymentioning

confidence: 99%

Section: Transpupillary Thermotherapymentioning

confidence: 99%

See 2 more Smart Citations

Uveal melanoma: relatively rare but deadly cancer

Kaliki

Shields

2016

Eye

468

533

View full text Add to dashboard Cite

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“…Лазеркоагуляция (D. Appel, 1973), а позднее транспупиллярная термотерапия (Journee J. de Korver, J. Oosterhuis, 1997) прочно заняли свою нишу среди органосохранных методов лечения. В качестве самостоятельного метода их с успехом используют для разрушения постэкваториальных начальных МХ, имеющих толщину до 2-2,5 мм, максимальный диаметр до 12 мм при наличии достаточной пигментации опухоли и отсутствии субретинальной жидкости [12][13][14][15]. Транспупиллярная термотерапия получила распространение и в комбинации с брахитерапией (БТ) для разрушения МХ средних размеров [10,[16][17][18][19][20][21][22][23][24].…”

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Local treatment of choroidal melanoma: possibilities and limitations

Brovkina¹

2018

Vestn. oftal'mol.

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Local treatment of choroidal melanoma (CM) attracts the attention of many ophthalmology specialists, especially in recent years as the capabilities to target irradiation at small objects and possibilities of surgical interventions on the eyeball have expanded. The article discusses the medical indications for local treatment of CM. Review of literature of the last 16 years and author's own observations on CM patients who underwent almost all kinds of conventional methods of local treatment allowed thorough analysis of indications and counter-indications for their usage. Among the authors who favor local destruction and removal of large CM, the main indication is the possibility to preserve vision and anatomical structures of the eye. This led to unreasonably wide spread of local destruction (removal) of large CM, primarily the endovitreal resection method. However, such metastasis risk factors as CM size and its localization are being overlooked. Literature analysis and author's own observations helped validate the unsafety of the local treatment of large CM. The article features long-term results of contact and distant radiation therapy, and presents CM metrics for best therapeutic effect.

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