Primary tracheobronchial tumors in children

Varela, Patricio; Pio, Luca; Torre, Michele

doi:10.1053/j.sempedsurg.2016.02.013

Cited by 29 publications

(45 citation statements)

References 42 publications

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“…Depending on the degree of the lumen obstruction, bronchiectasis and pulmonary atelectasis could appear, leading to chronic pneumonia (5). Haemoptysis could also appear as consequence of mucosal ulceration and bleeding (14). In relation to each histological type, the lack of pathognomonic symptoms lead to frequent misdiagnoses with other conditions (such as bronchitis, pneumonia or asthma) causing diagnostic delayed (2).…”

Section: Sign and Symptomsmentioning

confidence: 99%

“…Approximately half of all cases originates in the head and neck, with 10% of these one having a laryngeal involvement (12,13). In children, surgical resection should be considered because of recurrent obstructive symptoms, although malignant transformation has never been documented (14).…”

Section: Benign Tumorsmentioning

confidence: 99%

“…Although pneumonectomies and lobectomies have been typically performed for bronchial tumours, parenchyma-saving procedures, such as sleeve resections and bronchoplasties, are the main procedures performed recently (28). Bronchial carcinoid and mucoepidermoid carcinoma are reported to metastasize to the lymph nodes so that their biopsy is strictly recommended (14,24,29).…”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Huge neoplastic masses required cricotracheal resection with an end-to-end anastomosis. Extubation is usually carried out at the end of surgery, except for selected cases (14). Postoperative complications such graft infection or collapse, excessive proliferation of the granulation tissue, extensive malacia, vocal fold palsy or laryngotracheal stenosis could occur rarely (14).…”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Also in case of in case of infantile hemangioma, tracheostomy, which was commonly used in the past, is not required now. It should be performed in selected cases of severe tracheal obstructive symptoms, however it should be avoided when primary resection of the tumor or biopsy with endoscopic debulking could be possible (14).…”

Section: Surgical Treatmentmentioning

confidence: 99%

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Tracheal and bronchial tumors

Varela¹,

Pio²,

Brandigi³

et al. 2016

J. Thorac. Dis.

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Although primary tracheobronchial tumors are extremely rare in children, recurrent respiratory symptoms resistant to conventional therapy require further investigations to exclude possible malignant obstructive causes. As the matter of fact, early diagnosis may allow minimally invasive surgeries, improving the standard of living and the globally survival rate. The aim of this article is to provide an overview of diagnosis and management of tracheobronchial tumors in the early age, since only few reports are reported in the worldwide literature.

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Section: Sign and Symptomsmentioning

confidence: 99%

Section: Benign Tumorsmentioning

confidence: 99%

Section: Surgical Treatmentmentioning

confidence: 99%

Section: Surgical Treatmentmentioning

confidence: 99%

Section: Surgical Treatmentmentioning

confidence: 99%

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Tracheal and bronchial tumors

Varela¹,

Pio²,

Brandigi³

et al. 2016

J. Thorac. Dis.

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Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

et al. 2019

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Objective Primary tracheobronchial tumors (PTTs) are rare heterogeneous lesions arising from any part of the tracheobronchial tree. Nonspecific symptoms may lead to delayed diagnosis that requires more aggressive surgical treatment. An analysis of cases collected by the International Network of Pediatric Airway Team was undertaken to ensure proper insight into the behavior and management of PTTs. Methods Patients <18 years of age with a histological confirmation of PTT diagnosed from 2000 to 2015 were included in this multicenter international retrospective study. Medical records, treatment modalities, and outcomes were analyzed. The patient presentation, tumor management, and clinical course were compared between malignant and benign histotypes. Clinical and surgical variables that might influence event‐free survival were considered. Results Among the 78 children identified, PTTs were more likely to be malignant than benign; bronchial carcinoid tumor (n = 31; 40%) was the most common histological subtype, followed by inflammatory myofibroblastic tumor (n = 19; 25%) and mucoepidermoid carcinoma (n = 15; 19%). Regarding symptoms at presentation, wheezing (P = 0.001) and dyspnea (P = 0.03) were more often associated with benign growth, whereas hemoptysis was more frequently associated with malignancy (P = 0.042). Factors that significantly worsened event‐free survival were age at diagnosis earlier than 112 months (P = 0.0035) and duration of symptoms lasting more than 2 months (P = 0.0029). Conclusion The results of this international study provide important information regarding the clinical presentation, diagnostic workup, and treatment of PTTs in children, casting new light on the biological behavior of PTTs to ensure appropriate treatments. Level of Evidence NA Laryngoscope, 130:E243–E251, 2020

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Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children

Yang

Yin

Tang

et al. 2021

Pediatric Investigation

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ImportancePediatric hypervascular primary airway tumors are progressive, fatal lesions with a low incidence, and the disease is often more serious than that in adults.ObjectiveTo evaluate the clinical efficacy and safety of interventional therapeutic bronchoscopy combined with conservative treatment and bronchial arterial embolization in children with primary airway tumors.MethodsWe retrospectively analyzed the clinical data of four pediatric patients with hypervascular primary airway tumor between 2017 and 2019 at Beijing Children’s Hospital.ResultsTwo patients were low‐grade bronchial mucoepidermoid carcinoma, one patient was pleomorphic adenoma, and one was bronchial leiomyoma. Interventional therapeutic bronchoscopy combined with bronchial arterial embolization was used for treatment (all four patients received general anesthesia). The tumors were safely resected in all patients via interventional bronchoscopy. There were no severe complications related to the procedures. All patients were followed up for 5–12 months, and one low‐grade bronchial mucoepidermoid carcinoma recurred.InterpretationInterventional therapeutic bronchoscopy combined with bronchial arterial embolization appears to be a safe and efficient therapeutic method associated with less trauma and fewer complications, including no serious adverse events, in children with hypervascular primary airway tumors without bronchus wall infiltration.

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Primary tracheobronchial tumors in children

Cited by 29 publications

References 42 publications

Tracheal and bronchial tumors

Tracheal and bronchial tumors

Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children

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