Primary tracheal tumours: 21 years of experience at Peking Union Medical College, Beijing, China

Zhengjaiang, L; Tang, Ping-zhang; Zhang, De-Chao; Reddy-Kolanu, Guna; Ilankovan, V.

doi:10.1017/s0022215108001710

Cited by 17 publications

(17 citation statements)

References 9 publications

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“…The location of the tumor, which has rarely been studied in previous reports, seems to have significant prognostic value. In our study, malignant PTTs were mainly located in the upper and lower third of the trachea, which is in agreement with previous reports ( 13 ). The location of tumors might play a role in the prognosis.…”

Section: Discussionsupporting

confidence: 94%

Clinical features and prognosis analysis of 57 patients with primary tracheal tumors

Jiang¹,

Lei²,

Lv³

et al. 2020

Transl Cancer Res TCR

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Background: Primary tracheal tumor (PTT) is a rare disease with poor prognosis. Its clinical features are variable. Treatment strategies for patients with PTTs are not standardized. The purpose of this study was to explore the clinical features, management and prognosis of PTT.Methods: From 2009 to 2019, 57 patients were diagnosed with PTTs at Xiangya Hospital, China. A retrospective review of their medical records was performed.Results: Among the 57 patients, 8 (14.0%) had benign tumors and 49 (86.0%) had malignant. Squamous cell carcinoma (SCC) (n=20, 40.8%) and adenoid cystic carcinoma (ACC) (n=10, 20.4%) were the most common histologic types. Seven (87.5%) of the benign PTT patients underwent bronchoscopic intervention and had no further complications. The 5-year survival rate for malignant PTTs was 13.8%. Patients who had ACC tended to have better survival rates than those with SCC, although the difference was not statistically significant (P=0.104). Compared with tumors located in upper third of the trachea, tumors located in the lower portion showed worse survival (P=0.0003). Patients who underwent complete surgical resection had significantly better survival compared to non-surgical therapies (P=0.016). The combination of chemoradiotherapy and bronchoscopic intervention was better than chemoradiotherapy alone (P=0.028).Conclusions: Histologic type, tumor location and treatment approaches likely influence clinical outcomes.Within the cohort described here, complete surgical resection was the optimal therapy for PTTs. For unresectable malignant PTTS, chemoradiotherapy with bronchoscopic intervention was a superior modality.Given the poor 5-year survival of PTT, larger-scale, multi-center studies are warranted to validate our findings and identify optimal therapeutic interventions.

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Section: Discussionsupporting

confidence: 94%

Clinical features and prognosis analysis of 57 patients with primary tracheal tumors

Jiang¹,

Lei²,

Lv³

et al. 2020

Transl Cancer Res TCR

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“…Gaissert et al9 compared the survival outcomes between 101 patients with ACCs and 90 patients with SCCs and found that the prognosis of ACCs was significantly superior to SCCs (5-year OS 52% vs. 39%, P <0.001). Another study based on oriental populations35 also suggested an approximately twofold 5-year survival rate disparity between these two subtypes. In our study, SCCs were more likely to present with local extension, as well as lymph node metastasis, than ACCs at diagnosis.…”

Section: Discussionmentioning

confidence: 91%

Nomograms for predicting survival outcomes in patients with primary tracheal tumors: a large population-based analysis

Wen¹,

Liu²,

Xu³

et al. 2018

CMAR

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BackgroundThe aim of this study was to develop and validate reliable nomograms to predict individual overall survival (OS) and cancer-specific survival (CSS) for patients with primary tracheal tumors and further estimate the role of postoperative radiotherapy (PORT) for these entities.Patients and methodsA total of 405 eligible patients diagnosed between 1988 and 2015 were selected from the Surveillance, Epidemiology, and End Results database. All of them were randomly divided into training (n=303) and validation (n=102) sets. For the purpose of establishing nomograms, the Akaike information criterion was employed to select significant prognostic factors in multivariate Cox regression models. Both internal and external validations of the nomograms were evaluated by Harrell’s concordance index (C-index) and calibration plots. Propensity score matching (PSM) method was performed to reduce the influence of selection bias between the PORT group and the non-PORT group.ResultsTwo nomograms shared common variables including age at diagnosis, histology, N and M stages, tumor size, and treatment types, while gender was only incorporated in the CSS nomogram. The C-indices of OS and CSS nomograms were 0.817 and 0.813, displaying considerable predictive accuracy. The calibration curves indicated consistency between the nomograms and the actual observations. When the nomograms were applied to the validation set, the results remained reconcilable. Moreover, the nomograms showed superiority over the Bhattacharyya’s staging system with regard to the C-indices. After PSM, PORT was not associated with significantly better OS or CSS. Only squamous cell carcinoma (SCC) patients in the PORT group had improved OS compared to non-PORT group.ConclusionThe first two nomograms for predicting survival in patients with primary tracheal tumors were proposed in the present study. PORT seems to improve the prognosis of SCC patients, which needs further exploration.

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“…Many studies in different parts of the world have shown that resection extends the survival of patients with ACC [3,5,8,9,[13][14][15][16][17]. In our ACCs, the resected group had a significantly longer survival as well.…”

Section: Discussionmentioning

confidence: 55%

Primary major airway tumors; management and results

Shadmehr

Farzanegan

Graili

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Primary tracheal tumours: 21 years of experience at Peking Union Medical College, Beijing, China

Cited by 17 publications

References 9 publications

Clinical features and prognosis analysis of 57 patients with primary tracheal tumors

Clinical features and prognosis analysis of 57 patients with primary tracheal tumors

Nomograms for predicting survival outcomes in patients with primary tracheal tumors: a large population-based analysis

Primary major airway tumors; management and results

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