Primary thyroid leiomyosarcoma: A case report and literature review

Zou, Zhiwei; Ning, Ning; Li, Song‐Yan; Li, Jie; Du, Xiaohui; Li, Rong

doi:10.3892/ol.2016.4496

Cited by 12 publications

(36 citation statements)

References 22 publications

(65 reference statements)

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“…Radiotherapy and chemotherapy cannot improve patient survival, and surgery is currently the most effective treatment method for primary thyroid LMS; however, local recurrence and metastasis still occur in 75% of patients. Thyroid LMS is a fatal tumor with an extremely poor prognosis and lacks effective treatment regimens, and most patients die within 1 year of diagnosis [16]. For that reason, some studies explore the effectiveness of molecularbased treatment strategies.…”

Section: Discussionmentioning

confidence: 99%

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Hao

Huang

Tian

et al. 2020

Preprint

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Background Primary thyroid leiomyosarcoma(LMS) is very rare, with only 30 cases reported worldwide. Thyroid LMS should be diagnosed with caution and comprehensively evaluated considering clinical, imaging, and pathological data. It is a kind of fatal tumor with an extremely poor prognosis and lacks effective treatment regimens, and most patients die within 1 year of diagnosis. Here, we present a case report on a patient with Primary thyroid LMS. Case presentation A 76-year-old woman presented with hoarseness, dysphagia, and dyspnea when lying down for the past 1 month visited our hospital. She had a history of right neck masses in the past 2 years. A hard, irregular tumor of approximately 8 cm × 5 cm × 5 cm was observed on the right lobe of the thyroid, the boundary between which and the surrounding tissues was unclear. The tumor anteriorly invaded the cervical muscles and interiorly invaded the right walls of the trachea and esophagus. Most tumor tissues were excised, a curative operation seemed impossible. Immunohistochemically, the tumor cells were positive for Calponin, vimentin and SMA, but negative for EMA, CK, P53, Desmin and S-100. Tumor recurrence and progression were considered two months after surgery, the patient refused follow-up treatment for personal reasons and died 4 months after surgery. Conclusion Thyroid LMS accounting for merely 0.014% of primary thyroid tumors of unknown etiology. The diagnosis can only be confirmed upon a lack of evidence regarding epithelial differentiation or other types of sarcoma differentiation and when immunohistochemistry yields positive smooth muscle markers. Primary thyroid LMS is primarily surgically resected and no other effective treatment currently available. Disease progression is rapid, the prognosis is poor, and the 1-year survival rate is <10%. In the present study, a rare case of a 76-year-old female patient diagnosed with thyroid LMS was reported and a review of the literature is presented.

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Section: Discussionmentioning

confidence: 99%

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Hao

Huang

Tian

et al. 2020

Preprint

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“…Among all tumours of the thyroid gland, primary thyroid LMS accounts only for 0.014%. 17 They usually develop in older people (mean age 66 years) with no gender predisposition. 20 Primary thyroid LMS most commonly presents as a painless, rapidly-growing neck mass.…”

Section: Discussionmentioning

confidence: 99%

“…Primary LMS of the thyroid is a rare tumour and approximately only 30 cases have been reported previously. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The other common sites for LMS are gastrointestinal tract, retroperitoneum and pelvis. 23 According to the histological tumour classification by World Health Organization (WHO), thyroid LMS is classified as a member of the smooth-muscle tumours of thyroid gland.…”

mentioning

confidence: 99%

Primary Leiomyosarcoma of the Thyroid Gland – A Rare Malignancy

Reddy¹,

Aggarwal²,

Ak³

et al. 2019

European Endocrinology

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“…Leiomyosarcoma (LMS) is a relatively rare soft-tissue tumor that can arise from any organ or structure containing smooth muscle, most often occurs in the retroperitoneum, the digestive tract, pelvis, skin and soft tissue (1,2). Primary thyroid LMS is rare, and may be associated with smooth muscle-walled vessels at the periphery of the thyroid gland capsule; however, the pathogenesis of primary thyroid LMS remains unclear (1–17). To the best of our knowledge, only 25 cases have been reported in English literature (1–17).…”

Section: Introductionmentioning

confidence: 99%

“…Primary thyroid LMS is rare, and may be associated with smooth muscle-walled vessels at the periphery of the thyroid gland capsule; however, the pathogenesis of primary thyroid LMS remains unclear (1–17). To the best of our knowledge, only 25 cases have been reported in English literature (1–17). LMS is composed of cells with distinct smooth muscle histological differentiation, and the diagnosis is confirmed by immunohistochemical techniques combined with clinical history (4).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

et al. 2018

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Primary thyroid leiomyosarcoma (LMS) is a rare tumor type with an unusual location, the diagnosis is based entirely on histological and immunohistochemical evaluations. In the present study, a rare case of a 74-year-old female patient who exhibited a right anterior neck mass for 12 months, which rapidly enlarged for the last 3 months. Ultrasound of the thyroid revealed a 55×42 mm hypoechoic mass with clear margins in the right lobe. Histological examination of the tumor demonstrated malignant spindle cells in interlacing fascicles and whorls. Additionally, nuclear pleomorphism, tumor giant cells, necrosis and abnormal mitotic figures were observed. The immunohistochemistry indicated that the tumor cells were strongly positive for smooth muscle actin, desmin, p53 and vimentin expression, but negative for cytokeratin, epithelial membrane antigen, thyroid transcription factor-1, paired box-8, 34βE12, cytokeratin 5/6, cluster of differentiation (CD)117, myoglobin, S100, p16. The final histopathological diagnosis was primary thyroid LMS.

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Primary thyroid leiomyosarcoma: A case report and literature review

Cited by 12 publications

References 22 publications

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Primary Leiomyosarcoma of the Thyroid Gland – A Rare Malignancy

Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

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