Primary thrombophilia XV: antithrombotic treatment of sticky platelet syndrome worldwide

García-Navarrete, Yarely Itzayana; Vallejo-Villalobos, María Fernanda; Olivares-Gazca, Jesús Mauricio; Cantero-Fortiz, Yahveth; León‐Peña, Andrés A.; Olivares‐Gazca, Juan Carlos; Murrieta-Álvarez, Iván; Ruíz-Delgado, Guillermo J.; Ruíz‐Argüelles, Guillermo J.

doi:10.21037/aob.2019.06.05

“…As a result of our interest in the SPS and with the assistance of various collaborators and of the previously mentioned giant clotters, we have now pieced several features of the SPS which can be summarized as follows [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] :…”

Section: La Troisième…mentioning

confidence: 99%

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2023

Semin Thromb Hemost

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“…As a result of our interest in the SPS and with the assistance of various collaborators and of the previously mentioned giant clotters, we have now pieced several features of the SPS which can be summarized as follows 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 :…”

Section: La Troisième…mentioning

confidence: 99%

Professor Peter Kubisz (1942–2022)—Un hommage à trois étincelles

Ruíz‐Argüelles

¹

2022

Semin Thromb Hemost

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“…In most cases, acetylsalicylic acid (ASA) appears to be an adequate option but there are situations in which other antiplatelet drugs are needed. 47 Patients that are allergic or intolerant to aspirin can be managed with clopidogrel, and in cases in which platelet hyperreactivity persists over an established time period, the combination of ASA and clopidogrel at the usual doses appears to provide good results. For example, in a study published in 2015 which analyzed the results of treatment in 55 patients with SPS Source: Ref.…”

Section: Sps and Current Managementmentioning

confidence: 99%

“…In most cases, acetylsalicylic acid (ASA) appears to be an adequate option but there are situations in which other antiplatelet drugs are needed. 47 Patients that are allergic or intolerant to aspirin can be managed with clopidogrel, and in cases in which platelet hyperreactivity persists over an established time period, the combination of ASA and clopidogrel at the usual doses appears to provide good results. For example, in a study published in 2015 which analyzed the results of treatment in 55 patients with SPS followed for a median of 129 months, the authors found that after the administration of antiplatelet drugs, particularly ASA platelet hyperreactivity in patients with the SPS phenotype could be reverted, leading to a substantial decrease in the rate of rethrombosis.…”

Section: Salient Features Of the Sps Phenotypementioning

confidence: 99%

Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype

García-Villaseñor

¹

,

Bojalil-Álvarez

²

,

Murrieta-Álvarez

³

et al. 2021

Clin Appl Thromb Hemost

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The sticky platelet syndrome (SPS) was described by Mammen in 1983. Since then, scientists in several countries have identified the condition and published cases or series of patients, thus enabling the description of the prevalence of the inherited condition, its salient clinical features, and the treatment of the disease. The diagnosis of the SPS phenotype requires fresh blood samples and special equipment which is not available in all coagulation laboratories. In the era of molecular biology, up to now it has not been possible to define a clear association of the SPS phenotype with a specific molecular marker. Some molecular changes which have been described in platelet proteins in some persons with the phenotype of the SPS are here discussed. Nowadays, the SPS phenotype may be considered as a risk factor for thrombosis and most cases of the SPS developing vaso-occlussive episodes are the result of its coexistence with other thrombosis-prone conditions, some of the inherited and some of them acquired, thus leading to the concept of multifactorial thrombophilia. Ignoring all these evidence-based concepts is inappropriate, same as stating that the SPS is a nonentity simply because not all laboratories are endowed with adequate equipment to support the diagnosis.

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Primary thrombophilia XV: antithrombotic treatment of sticky platelet syndrome worldwide

Cited by 6 publications

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Professor Peter Kubisz (1942–2022)—Un hommage à trois étincelles

Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype

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