Primary Thrombophilia in Mexico XIII: Localization of the Thrombotic Events in Mexican Mestizos With the Sticky Platelet Syndrome

Abstract

The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. To analyze the localization of the thrombotic episodes in a cohort of Mexican mestizo patients with SPS. Between 1992 and 2016, 86 Mexican mestizo patients with SPS as the single thrombophilic condition were prospectively identified; all of them had a history of thrombosis. There were 15 males and 71 females. The thrombotic episodes were arterial in 26 cases and venous in 60 (70%). Arterial thrombosis was mainly pulmonary thromboembolism, whereas venous thromboses were identified most frequently in the lower limbs. Mexican mestizo population with SPS is mainly female; the type I of the condition is the most frequent; both arterial and venous thrombosis can occur, and they are mainly pulmonary embolism and lower limbs venous thrombosis, respectively.

Untitled

“…As a result of our interest in the SPS and with the assistance of various collaborators and of the previously mentioned giant clotters, we have now pieced several features of the SPS which can be summarized as follows [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] :…”

Professor Peter Kubisz (1942–2022)—Un hommage à trois étincelles

“…As a result of our interest in the SPS and with the assistance of various collaborators and of the previously mentioned giant clotters, we have now pieced several features of the SPS which can be summarized as follows 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 :…”

Primary Thrombophilia XVII: A Narrative Review of Sticky Platelet Syndrome in México

“…Caucasians suffer from SPS type II more frequently [ 20 ], whereas type I is more frequently seen in Mexican Mestizos. SPS is also the second most common cause of thrombophilia in this ethnic group [ 21 ]. We also conducted a study to define the identification of SPS worldwide and found that patients with the condition have been identified and reported in the five continents [ 12 ].…”