Primary thrombophilia in Mexico: A prospective study

Ruíz‐Argüelles, Guillermo J.; González‐Estrada, Sonia; Garcés‐Eisele, Javier; Ruı́z-Argüelles, Alejandro

doi:10.1002/(sici)1096-8652(199901)60:1<1::aid-ajh1>3.3.co;2-h

Cited by 8 publications

(22 citation statements)

References 20 publications

(35 reference statements)

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“…Thus, the frequency of factor V Leiden among individuals with APC resistance in our population differs substantially from what has been observed in Caucasian populations, in which about 90% of the cases with APC resistance are associated with the factor V Leiden mutation. Similar results have been reported in the Mexican population, in which the factor V Leiden mutation underlied only 10% of APC resistance cases [5,16].…”

Section: Discussionsupporting

confidence: 88%

“…The Colombian population can be defined as a ''tri-ethnic population,'' whose genetic background is roughly 70% Caucasian (mainly Spanish), 15% Amerindian, and 15% African [3,4]. This is a different distribution from that reported for Mexico, Argentina, and the United States [2,5,6]. In this study, we evaluated Colombian patients with deep vein thrombosis (DVT) and healthy blood donors, in order to assess the frequency of primary thrombophilic defects, including activated protein C resistance (APC resistance), the factor V Leiden mutation (factor V G1691A), the prothrombin G20210A mutation, and the methylenetetrahydrofolate reductase thermolabile variant (MTHFR C677T), as risk factors for thrombosis in this population.…”

Section: Introductionmentioning

confidence: 99%

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Inherited thrombophilia is associated with deep vein thrombosis in a Colombian population

et al. 2006

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The development of venous thromboembolism is influenced by a variety of genetic and environmental risk factors. A few studies have ascertained whether thrombophilic defects are risk factors for venous thromboembolism in Latin American populations with a variable degree of admixture, such as the Colombian population. To address this issue, we conducted a case-control study involving 100 consecutive patients with deep vein thrombosis and 114 healthy controls from the Hospital Universitario San Vicente de Paú l, Medellín, Colombia. Activated protein C resistance (APC resistance) was detected in 25/99 patients vs. 6/114 controls (OR 5 6.08, 95% CI 5 2.23-17.47). Ten of 100 patients carried the factor V Leiden mutation vs. 1/114 controls (OR 5 12.56, 95% CI 5 1.61-267). APC resistance was associated with the factor V Leiden mutation in only 10/25 patients. The prothrombin G20210A mutation was found in 4/100 patients, but none of the controls (P < 0.05). There was no significant difference in the proportion of homozygous carriers of methylenetetrahydrofolate reductase C677T variant among patients and controls. In conclusion, in our studied population, factor V Leiden, APC resistance, and prothrombin G20210A were associated with an increased risk of deep vein thrombosis. However, the frequencies of these thrombophilic defects and of APC resistance associated with factor V Leiden was lower than the corresponding frequencies previously reported for Caucasian populations. Further study is required to assess the influence of ethnicity on thrombophilia. Am. J. Hematol. 81:933-937, 2006. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Inherited thrombophilia is associated with deep vein thrombosis in a Colombian population

et al. 2006

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“…There is clinical and experimental evidence that changes in the hemostasis can lead to a hypercoagulable or thrombogenic state in the circulation that can foster thrombus formation [1][2][3][4]. In recent years, we have been analyzing changes in the hemostatic system of Mexican mestizos, which can result in thrombophilia, and we have found different anomalies in several natural antithrombotic mechanisms [1][2][3][4]. In an effort to further clarify the causes of thrombophilia in Mexican mestizos, we have prospectively assessed several thrombophilic conditions in a group of 46 consecutive Mexican mestizos.…”

Section: Introductionmentioning

confidence: 99%

Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial

et al. 2004

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Over a 36-month period, 46 consecutive Mexican mestizos with a clinical marker associated with a primary hypercoagulable state were prospectively assessed by searching for the sticky platelet syndrome (SPS), the activated protein C resistance (aPCR) phenotype, coagulation protein C activity and antigen, coagulation protein S, antithrombin III, plasminogen, tissue-type plasminogen activator activity, plasminogen activator inhibitor activity, plasminogen activator inhibitor type 1, IgG and IgM isotypes of antiphospholipid antibodies, homocysteine levels, the factor V gene Leiden, Cambridge, Hong Kong, and Liverpool mutations, the 677 CfiT mutation in the 5,10-methylenetetrahydrofolatereductase (MTHFR), and the G20210A polymorphism in the 3¢-untranslated region of the prothrombin gene. Of the 46 consecutive patients prospectively accrued in the study, only 12 (26%) were males, the median age being 38 years (range 10-63 years). In only four individuals (8%) could we not record any abnormality. In 5/42 patients with abnormal results (12%), a single abnormality was recorded, whereas in the remaining 37, two to five co-existing abnormalities were identified. We found 22 (48%) patients with the SPS, 11 (24%) with the aPCR phenotype, 5 (11%) with the factor V Leiden mutation, 7 (15%) with the prothrombin gene mutation, 29 (63%) with the MTHFR gene mutation, 11 (24%) with the factor V HR2 haplotype, 11 (24%) with antiphospholipid antibodies, 4 (9%) with PS deficiency, 6 (13%) with PC deficiency, one with the FV Hong Kong mutation, and one with AT-III deficiency. The results are consonant with the idea that most cases of thrombophilia in Mexico are multifactorial. Am.

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“…It seems that the statement of Ruiz-Argü elles lacks congruency because in his publications prevalence of FV Leiden widely varies from 4% to 11%. [3][4][5][6] . On the contrary, our research was done in a truly representative sample of healthy individuals from the whole Mexican Republic.…”

Section: Dear Editormentioning

confidence: 53%

“…He claims that the description of the low incidence of FV Leiden was done in one of his papers. 3 However, this descriptive research was performed in a very small, nonsignificant sample of patients with primary thrombophilia. He claims that derived from his results (in thrombophilic populations), ''it is clear that the prevalence of the FV Leiden mutation in Mexican Indians and/or mestizos is very low.''…”

Section: Dear Editormentioning

confidence: 99%

Response to Factor V Leiden in Mexico

Majluf‐Cruz

2009

Clin Appl Thromb Hemost

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References 1. Ruiz-Arguelles G. Factor V Leiden in Mexico. Clin Appl Thromb Hemost. 2009.[Epub ahead of print]. 2. Césarman-Maus G, Villazó n S, Zú ñ iga J, et al. Absence of factor V Leiden mutation in Mazateco Indians: A polymorphism of recent acquisition in the Americas. Int J Haematol. 1996;64(suppl 1):s111. 3. Ruiz-Argü elles GJ, González-Estrada S, Garcés-Eisele J, Ruiz-Argü elles A. Primary thrombophilia in México: A prospective study. Am J Hematol. 1999;60(1):1-5. 4. Ruiz-Argü elles GJ, Ló pez-Martínez B, Valdés-Tapia P, Gó mez-Rangel JD, Reyes-Nú ñ ez V, Garcés-Eisele J. Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol. 2005;78(1):21-26. 5. Ruiz-Argü elles GJ, Poblete-Naredo I, Reyes-Nú ñ ez V, Garcés-Eisele J, Ló pez-Martínez B, Gó mez-Rangel JD. Primary thrombophilia in Mexico IV: frequency of the Leiden, Cambridge, Hong Kong, Liverpool and HR2 haplotype polymorphisms in the factor V gene of a group of thrombophilic Mexican Mestizo patients. Rev Invest Clin. 2004;56(5):600-604. 6. Ruiz-Argü elles GJ, Garcés-Eisele J, Reyes-Nú ñ ez V, Ramírez-Cisneros FJ. Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos. Am J Hematol. 2001;66(1):28-31. For reprints and permissions queries, please visit SAGE's Web site at http://www.sagepub.com/journalsPermissions.nav Clinical and Applied Thrombosis/Hemostasis

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Primary thrombophilia in Mexico: A prospective study

Cited by 8 publications

References 20 publications

Inherited thrombophilia is associated with deep vein thrombosis in a Colombian population

Inherited thrombophilia is associated with deep vein thrombosis in a Colombian population

Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial

Response to Factor V Leiden in Mexico

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