Primary thoracic neuroblastoma in an adult

Tan, Yinuo; Li, Jin-Fan; Li, Wen‐Shan; Yang, Run-Lin

doi:10.1097/md.0000000000016564

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Adult neuroblastomas occur in similar sites as that of children, most commonly involving the abdomen and pelvis (adrenal medulla) followed by head and neck, thorax and extremities 6 . Rare sites of occurrence has also been reported in literature, including primary cerebral neuroblastomas and thoracic neuroblastomas 7,8 . All the three cases in this study were of adrenal origin which is the most common site of origin of these tumors.…”

Section: Discussionsupporting

confidence: 65%

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Neuroblastoma in uncommon age group – A case series diagnosed on cytology

Dharmalingam,

Chenniappan,

Alashetty

et al. 2023

Diagnostic Cytopathology

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BackgroundNeuroblastoma is the most common extracranial malignant neoplasm in early childhood. It is rare in the adult population.Aims and ObjectivesWe aimed to study the incidence of neuroblastoma in the uncommon age group diagnosed on cytology.Materials and MethodsA prospective descriptive study spanning 2 years from December 2020 to January 2022 was done, in which neuroblastoma cases diagnosed by Fine needle aspiration cytology aged >12 years were collected. The clinical, cytomorphological and immunohistochemical findings were studied. Histopathological correlation was done wherever available.ResultsWe identified three cases of neuroblastoma during this period. Two cases were middle‐aged adults, and one was an adolescent. All cases presented with abdominal masses and revealed small round cell tumor on cytology. Two cases fell into undifferentiated category and one case fell into the poorly differentiated subtype. All cases were positive for neuroendocrine markers. Histopathological correlation was available in two cases. MYC N amplification was absent in all cases.ConclusionIt differs from pediatric neuroblastoma due to the lack of classical histomorphological features and molecular alterations. Adult‐onset neuroblastomas carry a worse prognosis than childhood tumors.

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Section: Discussionsupporting

confidence: 65%

“…6 Rare sites of occurrence has also been reported in literature, including primary cerebral neuroblastomas and thoracic neuroblastomas. 7,8 All the three cases in this study were of adrenal origin which is the most common site of origin of these tumors.…”

Section: Discussionmentioning

confidence: 79%

Neuroblastoma in uncommon age group – A case series diagnosed on cytology

Dharmalingam,

Chenniappan,

Alashetty

et al. 2023

Diagnostic Cytopathology

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“…In general, the treatment principle is decided by the risk assessment system. (14,15) In patients with localized disease and low risk, surgery is the primary treatment modality, without the need for adjuvant chemotherapy and/or radiotherapy. (16,17) For intermediate risk patients, surgery associated with polychemotherapy (doxorubicin, cyclophosphamide, platinum, and etoposide) is the standard treatment, with radiotherapy used only if progression and/or spinal cord compression.…”

Section: Introductionmentioning

confidence: 99%

Case report: a rare mediastinal neuroblastoma in an adult associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

Souza,

Patury,

Slaibi Filho

et al. 2023

BJOncology

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Neuroblastoma is an embryonic cancer arising from neural crest stem cell and almost exclusively a pediatric neoplasm. In adults, neuroblastoma is rare and presents worse prognosis compared to children. The most common presentation of this neoplasia is a painless abdominal mass. Other signs and symptoms can be related to mass effect from the primary tumor or as a result of metastatic disease, or paraneoplastic syndromes. There are no well-established treatment guidelines for adults with neuroblastoma. In general, the principle of treatment is determined by risk assessment system, using a multimodal treatment (surgery, chemotherapy, and radiotherapy) based on treatment protocols for this neoplasm in children. This case report refers to the diagnosis of neuroblastoma in mediastinum in a 52-year-old woman with locally advanced disease and not able to be removed to diagnosis, accompanied by hyponatremia as paraneoplastic syndrome, which presented a good response to the treatment established.

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“…2 There are no standard treatment protocols for adult-onset neuroblastomas and there are only a few published case reports on neuroblastoma in adults. [3][4][5][6][7] Dinutuximab was approved in 2015 by the Food and Drug Administration for high-risk neuroblastoma in pediatric patients who achieve at least a partial response to prior first-line multimodal therapy. While dinutuximab has produced promising outcomes in pediatric patients, it is not without potentially severe adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Dinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma

Garrovillo

Garrett

Bollin

et al. 2020

J Oncol Pharm Pract

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Introduction Neuroblastoma is the most common extracranial solid tumor in pediatrics but is considerably uncommon in adults, with approximately 1 case per 10 million diagnosed per year and is associated with poor prognosis. There are no standard treatment protocols for adult-onset neuroblastomas and there are only a few published case reports on neuroblastoma in adults. Case report We report our treatment experience in a 41-year-old female diagnosed with high-risk, poorly differentiated neuroblastoma. Management and outcome Our patient received two cycles of dinutuximab adapted from the Children’s Oncology Group ANBL1221 protocol. The patient experienced pain, neuropathy, pruritus, and infusion reactions which were managed with supportive care. Due to the lack of tumor regression, dinutuximab was omitted from future treatments. Currently, the patient is asymptomatic from her disease and remains off of all therapy and pain medication. Discussion While dinutuximab has produced promising outcomes in pediatric patients, it is not without potentially severe adverse effects. Serious reactions of capillary leak syndrome, infusion reactions, pain, and neuropathy have been reported. Clinicians must be cognizant of the treatment-related toxicities associated with dinutuximab therapy, ranging from pain, neuropathy, pruritus, and infusion reactions as explored in this patient case.

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Primary thoracic neuroblastoma in an adult

Cited by 4 publications

References 20 publications

Neuroblastoma in uncommon age group – A case series diagnosed on cytology

Neuroblastoma in uncommon age group – A case series diagnosed on cytology

Case report: a rare mediastinal neuroblastoma in an adult associated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

Dinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma

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