Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes

Abstract

A treatment strategy for adults with chemosensitive T-LBL that includes planned consolidation with SCT in first response produces favorable long-term outcome.

Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma

“…LL is rare in adult patients, the most recent prospective series dealing with 27-34 total patients (a figure comparable to our study), with only a single study from Germany including exceptionally 45 patients [8,9,19,20]. In the NILG program, induction chemotherapy was integrated with early mediastinal irradiation in patients with suboptimal tumor regression, whereas the molecular analysis of MRD was used for the first time in adult LL to decide between SCT and standard maintenance for postinduction therapy.…”

“…The protocol was designed such that patients who were found to be positive for MRD were switched from standard chemotherapy to allogeneic SCT (or alternatively to HD therapy with autologous stem cell support). Past studies have confirmed the therapeutic efficacy of SCT in adults with LL [19,29,30], with survival rates of 55-72%, which almost overlap with the best results obtained with chemotherapy. Although allogeneic SCT might no longer be a routine choice in the current era of improved chemotherapy results [3,8,9], it remains the most effective treatment modality for acute lymphoid malignancies beyond CR1 [31].…”

Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival

“…23 Palliative regimens included observation, radiation, immunotherapy alone, and non-anthracycline-based chemotherapy. High-dose chemotherapy included ALL-type regimens (n ϭ 2) 24 and high-dose chemo-radiotherapy followed by hematopoietic stem cell transplantation (autologous n ϭ 3; and allogeneic n ϭ 1). Ethical approval to perform this retrospective study was granted by the University of British Columbia-British Columbia Cancer Agency Research Ethics Board and is in accordance with the Declaration of Helsinki (REB no.…”

Non-Hodgkin lymphoma: the clinician's perspective—a view from the receiving end

“…[29][30][31][32][33] Virus-Associated Lymphomas Two lymphomas seen in adults are known to be causally associated with specific viruses. Adult T-cell leukemia/lymphoma is a T-cell lymphoma that is caused by human T-cell lymphotropic virus type 1.…”