Primary testicular diffuse large B-cell lymphoma

Abstract

Rationale: Primary testicular lymphoma (PTL) is a rare type of extranodal non-Hodgkin's lymphoma (NHL). Although data of PTL in patients with diffuse large B-cell lymphoma (DLBCL) are accumulating, there are still patients respond poorly to prognosis. Patient concerns: All patients had disease of the DLBCL subtype and those patients had primary involvement of the testis. In our studies, eleven patients had stage I/II disease, and 3 patients had advanced disease with B symptoms. Four patients exhibited a MYC+, BCL2+, and BCL6- expression pattern, 4 patients had a MYC+, BCL6+, and BCL2- expression pattern, and 3 patients had a MYC+, BCL2+, and BCL6+ expression pattern. Additionally, 43% (7/16) of PT-DLBCL patients had a germinal center B-cell-like (GCB) phenotype, while the others had a non-GCB phonotype. Diagnoses: In our case, most patients presented with unilateral painless scrotal swelling and the enlargement of the testicles in the first examination. After hospitalization, all patients underwent preoperative imageological examination of the testis and epididymis and postoperative revealed that all patients were the diffuse infiltration of a large number of anomalous lymphocytes. In addition, no invasion of other sites was observed within 3 months after diagnosis. Interventions and outcomes: Underwent orchiectomy on the affected side was performed by urologists after all patients were diagnosed with PTL. Meanwhile, some patients received at least one course of chemotherapy, or received postoperative combined RT and chemotherapy. Because of it particularity, nineteen instances of lymph node region involvement were discovered in 12 patients since the operation. Lessons: PT-DLBCL has unique biological characteristics, and its treatment modalities are becoming increasingly standardized. In the future, systematic interventions need to be actively considered in the early stages of PTL.

Primary testicular lymphoma: Clinical characteristics and oncological outcomes

“…A recent study by Wang et al [6] included 16 patients with primary testicular-DLBCL. The median age of the patients was 62 years (range, 36–93 years).…”

“…These results are supported by our data: 12 patients (80%) presented with testicular swelling. Furthermore, Wang et al [6] showed that 11 of 16 patients had stage I or II disease and 3 of 16 had advanced disease with systemic symptoms. In contrast, 2 patients (13.33%) in our series had systemic symptoms, and 10 patients (66.67%) had advanced disease (Ann Arbor stage IVE).…”

Acute kidney injury leading to the diagnosis of sporadic testicular Burkitt's lymphoma: A case report

“…Testicular lymphoma is about 5 % of testis malignancies. Primary forms are usually “diffuse large B cell”, a high-grade histotype; metastatic ones often show Burkitt cells [8] . Herein, it was a primary TBL.…”

Linfoma no-Hodgkin testicular primario. Revisión de la literatura y reporte de caso

“…(20,21) La terapia multimodal consta de, la orquiectomía radical (diagnóstica terapéutica) seguida de quimioterapia R-CHOP (rituximab, ciclofosfamida, doxorubicina, vincristina y prednisona), radioterapia local (profiláctico para prevenir la recaída en ganglios linfáticos regionales o en los testículos contralaterales) y profilaxis del SNC con dosis altas de metotrexato con o sin quimioterapia intratecal, son opciones ampliamente aceptadas, que son adecuadas para uso clínico individual con niveles de evidencia de tipo 3. (21) El rituximab es un anticuerpo monoclonal quimérico anti-CD20 de inmunoglobulina humana G aprobado para el tratamiento del linfoma folicular recurrente. (22) La mayoría de las recaídas ocurren dentro de los primeros 1-3 años de la terapia inicial, principalmente en los sitios extra-nodales.…”