Primary teratocarcinoma of the lung

Stair, JM; Stevenson, Daniel R; Schaefer, Robert F.; Fullenwider, John; Campbell, Gilbert S.

doi:10.1002/jso.2930330413

Cited by 13 publications

(6 citation statements)

References 8 publications

(5 reference statements)

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“…A positron emission tomography G erm cell tumors are mostly encountered within the gonads or along the middle line in the mediastinum, retroperitoneum, sacral area, and skull basis, with the anterosuperior compartment of the mediastinum being the commonest location for extragonadal tumors. 1 Germ cell tumors of choriocarcinomatous or other nonseminomatous lineage that have allegedly risen into the lung have been rarely described, [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] and yolk sac tumor (YST) has usually been reported as one component of mixed germ cell tumors. 2,8,[10][11][12][13][14][15] Pure YST primary to the lung or pleura are exceptional events, with only very few cases reported in the English literature.…”

Section: Case Reportmentioning

confidence: 99%

A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme

et al. 2006

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Malignant extragonadal germ cell tumors primary to the lung are quite uncommon lesions, but pure yolk sac tumor is even more exceptional. This is believed to be the first reported case of yolk sac tumor of the lung in which an intense and diffuse immunoreactivity for CDX2, a marker of intestinal differentiation reportedly expressed also in gonadal yolk sac tumor, was associated with increased serum levels of the alkaline phosphatase intestinal isoform. Nine months after radical surgery and adjuvant chemotherapy, the patient is alive and well without evidence of recurrent or metastatic disease and with serum levels of the alkaline phosphatase intestinal isoform within normal limits. The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor.

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Section: Case Reportmentioning

confidence: 99%

A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme

et al. 2006

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“…Morgan et al [2], in 1992, reported a case and reviewed 30 literature cases. To their list, five more cases reported prior to 1992 but not included in their review should be added [5][6][7][8][9]. In 1993 Suzuki et al [10] reported two cases of benign pulmonary teratoma and cited 25 cases, including five cases with malignancy, in the Japanese literature.…”

Section: Discussionmentioning

confidence: 98%

Pulmonary Teratoma with Malignant Transformation

Chen

1998

Int J Surg Pathol

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A rare case of pulmonary teratoma with malignant transformation that occurred in a 58-year-old man is reported. The patient was treated initially with lobectomy. The tumor was composed of well-differentiated adenocarcinoma and mature teratomatous tissue that included squamous epithelium, sebaceous glands, cartilage, and pancreatic tissue. The patient developed recurrent adenocarcinoma in the lung 3 years later and was also found to have a renal cell carcinoma. Both the renal tumor and recurrent lung tumor were resected and adjuvant chemotherapy was given. He died of brain metastasis and further lung recurrence 9 months later. Int J Surg Pathol 6(2): [89][90][91][92] 1998 Most teratomas arise in ovaries and testicles. For extragonadal teratomas, the most frequent site is the anterior mediastinum; other, less common sites include retroperitoneum, the sacrococcygeal area, and the pineal region [1]. Primary pulmonary teratomas are extremely rare [2]. A case of pulmonary teratoma with malignant transformation (TMT) is herein reported and compared with those reported in the literature. Materials and MethodsFor light microscopic examination, the tissue was fixed in IO/% buffered formalin, routinely processed, and embedded in paraffin. Paraffin sections were stained with hematoxylin and eosin. A mucicarmine stain was performed on representative sections of the tumor.Immunohistochemical staining for chromogranin (dilution 1:200, BioGenex), neuron-specific enolase (dilution 1:150, BioGenex), and synaptophysin (dilution 1:80, BioGenex), with use of the avidin-biotin-peroxidase method was performed on representative sections of the tumor. Clinical HistoryA 58-year-old man presented with fever, chest pain, and dyspnea. A chest roentgenogram showed a large mass in the left lung. A bronchoscopy obtained mucoid material but histologic examination was negative for malignant cells. A left upper lung lobectomy was performed. Histologic examination of the lung mass showed well-differentiated adenocarcinoma arising in a teratoma. There was no clinical or radiographic evidence of extrapulmonary tumor. The testes were normal by palpation and ultrasonography. Three years later he developed hematuria. The chest roentgenograms showed two newly developed masses, 2 cm and 4 cm in size re-89 at Kungl Tekniska Hogskolan / Royal Institute of Technology on July 4, 2015 ijs.sagepub.com Downloaded from

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“…Li ke teratoma of the mediastinum , intrap 비 monary teratoma is thought to originate from the third pharyngeal pouch which is the anlage of the thymus (5,6) . It has two forms in relation to p 비 monary architecture , parenchymal and endobronchial.…”

Section: Discussionmentioning

confidence: 99%

“…Most of intrapulmonary teratomas were parenchymal , and only four cases of endobronchial teratoma have been reported (5 , 6) . Approximately half of the intrapulmonary teratomas were located in the left upper lobe, the reason of which is not clearly understood (6). These tumors have been said to have malignant potential , and approximately one -third have been reported to be malignant teratomas (5 , 6) .…”

Section: Discussionmentioning

confidence: 99%

An Intrapulmonary Cystic Teratoma: As a Cavitary Lung Lesion

Kim¹,

Kim²,

Joh³

et al. 1994

J Korean Radiol Soc

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We report a rare cause of lung cavities, occurring in a patient with intrapulmonary cystic teratoma. Computed tomography (CT) provided us more detailed informations about the tumor characteristics containing fat and calcification , which could not be distinguished on the plain radiographs.ln addition, CTscans clearly demonstrated the dilated anterior segmental bronchus of the left upper lobe entering the posterior aspect ofthe cavity. We recently experienced this rare condition in a 42-year -이 d man , manifested as a cavitary lung mass radiologically. Computed tomography (CT) provided us more informations about the characteristics of the tumor. CASE REPORTSAn acutely il l-i ooking , 42 -year -이 d man presented with fever , progressive dyspnea and chest pain which appeared two weeks ago. He was healthy until four years ago, when he suffered from pulmonary tubercu- Chest radiographs showed hydropneumothorax at the left side and a relatively thick-walled cavitary mass with a p 이 ypoid protrusion within the cavity at the left upper lobe. The diagnostic thoracentesis of hydropneumothorax revealed the grossly purulent fluid with the pH of 6.8 and the glucose level of less than 5 mg/dl , which prompted closed thoracotomy. Culture and cyt이 ogical examination of the empyemic fluid failed to identify a specific organism or celiular components. Chest radiographs obtained after closed thoracotomy more clearly demonstrated the cavitary mass at the left upper lobe (Fig. 1a). On CT scans , the cavity was located at the anterior segment of the left upper lobe with a portion of fungating mass which had several different tissue components including fat and calcification (Fig. 1 b). In addition , CT scans clearly demonstrated the dilated anterior segmental bronchus of the left upper lobe enteri ng the posterior aspect of the cavity (Fig. 1 C) .At thoracotomy , there was a severe , diffuse adhesion in the left pleural cavity containing pus, which urged the surgeon to perform a pleuropneumonectomy. About 5-cm sized mass was embedded in the anterior segment of the left upper 101갯 . Although there were some adhesions, it was relatively easy to separate the tumor with the mediastinum which was intact.The cut section ofthe specimen revealed the 4.6 X 4 X 3 cm -sized cavity with an internaliy protruding multino-

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Primary teratocarcinoma of the lung

Cited by 13 publications

References 8 publications

A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme

A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme

Pulmonary Teratoma with Malignant Transformation

An Intrapulmonary Cystic Teratoma: As a Cavitary Lung Lesion

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