Primary T-Cell Non-Hodgkin Lymphoma of the Vagina

Herráiz, José Luis; Llueca, Antoni; Maazouzi, Yasmine; Piquer, Dolors; Palmeiro, A.; Calpe, Enrique

doi:10.1155/2015/893083

Cited by 5 publications

(4 citation statements)

References 17 publications

(17 reference statements)

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“…Non-Hodgkin lymphoma (NHL) of the female gynecologic tract, either primary manifestation or secondary involvement from disseminated disease, is rare [ 1 ]. The most commonly affected area are the ovaries, and the most common complaint prompting consultation is abnormal vaginal bleeding [ 1 , 2 ]. The majority of cases are of B-cell origin, with diffuse large B-cell lymphoma (DLBCL) being the most common histologic subtype [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The majority of cases are of B-cell origin, with diffuse large B-cell lymphoma (DLBCL) being the most common histologic subtype [1,3]. T-cell lymphomas involving the gynecologic tract are far less common and typically have a poor prognosis [1][2][3][4][5][6][7]. Herein, we describe a case of anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK+ ALCL) with secondary involvement of the uterus and cervix successfully treated with systemic chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Disseminated Anaplastic Lymphoma Kinase (ALK)-Positive T-cell Lymphoma Involving the Uterus and Cervix: A Case Report

Yang,

Sabri,

Awad

et al. 2024

Cureus

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Primary or secondary non-Hodgkin lymphomas (NHLs) involving the female gynecologic tract are rare. T-cell subtypes are further rare and portend a worse prognosis. We present a case of a 23-year-old female presenting with a cervical mass accompanied by constitutional symptoms and abnormal vaginal bleeding. Immunohistochemistry studies revealed the presence of disseminated T-cell non-Hodgkin lymphoma that was anaplastic lymphoma kinase (ALK)-positive. The patient demonstrated a complete response to systemic chemotherapy initially and again after the relapse of the disease one year after diagnosis. To our knowledge, this is the first case of an ALK-positive T-cell lymphoma with secondary involvement of the uterus and cervix; all previously published cases of this histologic subtype in the gynecologic tract describe primary disease of the vagina. This case emphasizes the importance of immunohistochemistry studies inclusive of T-cell and B-cell markers when evaluating biopsies from cervical tumors to render the appropriate diagnosis and guide systemic therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disseminated Anaplastic Lymphoma Kinase (ALK)-Positive T-cell Lymphoma Involving the Uterus and Cervix: A Case Report

Yang,

Sabri,

Awad

et al. 2024

Cureus

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“…The most common histological subtype of gynecological lymphomas, primary or secondary, was Diffuse Large B-cell lymphoma 1 , 3 Vaginal T-cell lymphomas are extremely rare and there were only four cases reported since 2000. 3 , 4 , 5 , 6…”

Section: Introductionmentioning

confidence: 99%

Vaginal ALK-positive anaplastic large cell lymphoma treated with brentuximab vedotin: a case report and literature review

Cortez

Costa

Silveira

2022

Hematology, Transfusion and Cell Therapy

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“…The Merriam-Webster's Collegiate Dictionary defines lymphoma as the malignant form of lymphatic tissue and dates 1873 as when it was first named [1]. Now, there are single case reports from Turkey [2], India [3], Italy [4], Portugal [5], China [6], Japan [7], and Spain [8]. Therefore, having encountered the single case, which appeared among the Igbo ethnic group [9], this report is deemed to be worthy of demonstration.…”

Section: Introductionmentioning

confidence: 99%