Primary T-Cell Lymphoma of the Brain in a Patient at Advanced Stage of Aids

Aydın, Faruk; Bartholomew, Philip M.

doi:10.1097/00005072-199705000-00186

Cited by 3 publications

(11 citation statements)

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“…Primary CNS non‐Hodgkin's lymphomas in AIDS patients are predominantly of B‐cell origin, 2 although rare T‐cell lymphomas have been observed 5,6 . In AIDS patients, clinical comparison like location of CNS T‐ and B‐cell lymphomas is difficult because of the limited number of T‐cell lymphoma cases.…”

Section: Discussionmentioning

confidence: 99%

“…Although recent reports suggest that the CNS T‐cell lymphomas have an increase in their incidence in immunocompetent patients probably due to improved detection methods, advanced lymphoma typing techniques and increased medical awareness 4 . Only a few cases of CNS T‐lymphomas in patients with AIDS have been described previously 5,6 . Primary CNS lymphomas in AIDS occur with a frequency varying from 3% to 10% of patients, 7 of whom 16% appear with these tumors as their first AIDS‐defining illness 8 …”

Section: Introductionmentioning

confidence: 99%

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CNK/T‐cell brain lymphoma associated with Epstein‐Barr virus in a patient with AIDS

Cobo¹,

Talavera²,

Busquier

et al. 2007

Neuropathology

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We report a case of extranodal NK/T-cell lymphoma, nasal type, with exclusive cerebral localization in a patient with AIDS. The patient presented with neurological alterations, fever and convulsions, so the initial presumptive diagnosis was an opportunistic brain infection. MRI showed a left parietal necrotic lesion and a stereotactic brain biopsy was performed for pathological, microbiological and molecular studies. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype of this tumor was CD56+, CD45+, CD3+ (cytoplasmic), Granzyme B+ and Perforin+. All the microbiological studies such as bacterial, fungi, micobacteria, Toxoplasma gondii and Cryptococcus determination were negatives. A PCR study with primer specific for EBV viral genome of Bam-Hi-w system was positive. Also, a rearrangement study showed T-cell gene rearrangement with monoclonal appearance. A diagnosis of extranodal NK/T-cell lymphoma was made and the patient died a few days later. This case represents a very rare example of NK/T-cell lymphoma of the brain in a patient with AIDS. The diagnosis of this kind of lymphomas requires a multimodality approach correlating clinical, morphological, immunophenotypic and molecular data.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CNK/T‐cell brain lymphoma associated with Epstein‐Barr virus in a patient with AIDS

Cobo¹,

Talavera²,

Busquier

et al. 2007

Neuropathology

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“…A search of the medline database found only 6 other cases of T-cell pcnsl in aids patients [5][6][7][8][9] . Primary central nervous system lymphoma can present with focal or non-focal signs and symptoms that have usually been present for fewer than 3 months.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the reported cases are B-cell pcnsl. A search of the medline database for pcnsl in aids patients found only 6 cases [5][6][7][8][9] . Here, we present another case of an aids patient with T-cell pcnsl, treated successfully with and small new enhancing lesions bilaterally.…”

Section: Introductionmentioning

confidence: 99%

Primary Central Nervous System T-Cell Lymphoma in Aids Patients: Case Report and Literature Review

et al. 2010

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whole-brain radiation and highly active antiretroviral therapy (haart). CASE DESCRIPTIONA 43-year-old man presented to our hospital with headaches and right facial twitching for few days, associated with nausea and dizziness. His past medical history was significant for infection with hiv diagnosed 10 years earlier. Because of financial circumstances, the patient had stopped his haart 10 months earlier.On physical examination, the patient was alert and oriented. His vital signs were normal. He had a mild word-finding deficit, right facial droop, right pronator drift, and mild right arm hyperreflexia. The rest of the physical examination was normal.Laboratory work up showed a white blood cell count of 3400/mL, a CD4 count of 78/mL (normal: 493-1666/mL), an hiv viral load above 500,000/mL, positive Toxoplasma immunoglobulin G antibodies, negative serum cryptococcal antigen, and a nonreactive rapid plasma reagin test.Magnetic resonance imaging (mri) of the brain showed a large mass in the left frontoparietal region, with small non-enhancing lesions in the brain (Figure 1). A presumptive diagnosis of cerebral toxoplasmosis was made, for which the patient was treated with pyrimethamine, sulfadiazine, and leucovorin, with phenytoin for seizure prophylaxis. To avoid possible complications of anemia and immune reconstitution syndrome, haart was planned to be restarted 2 weeks later.The patient improved symptomatically and was discharged home. A follow-up brain mri 10 days later demonstrated no significant changes.One month later, the man came to our emergency department with a history of progressively increasing partial focal seizures that had started after he had stopped his medications 2 weeks earlier because of financial concerns. Brain mr i showed a slight increase of the old left frontoparietal lesion ABSTRACTAccording to the published data, most primary central nervous system lymphomas (pcnsls) are B-cell lymphomas; primary T-cell lymphomas are rare. In a search of the medline database, we found only 6 cases of primary T-cell pcnsl. Here, we present the case of a 43-year-old man with aids, not on highly active antiretroviral therapy, who presented with focal neurologic symptoms and was found on magnetic resonance imaging to have multiple brain lesions. A biopsy showed T-cell lymphoma, and the patient was subsequently treated with whole-brain radiation, to marked clinical response. Reported cases from the literature of primary T-cell pcnsl in aids patients are summarized in this review.

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“…These lymphomas are more frequent in immunocompetent patients though have also been described in immunosuppressed patients [2,3]. The etiology of this kind of lymphoma is unknown but NK/T-cell lymphomas of nasal type are constantly associated with EBV irrespective of the geographic origin [1]; although EBV has a special tropism with B-cell type, this virus can infect T and NK cells and this infection leads to a higher risk of lymphoma [4].…”

Section: Introductionmentioning

confidence: 99%

Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases

Cobo

Chamorro

Ramos

et al. 2009

Scholarly Research Exchange

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Primary T-Cell Lymphoma of the Brain in a Patient at Advanced Stage of Aids

Cited by 3 publications

References 0 publications

CNK/T‐cell brain lymphoma associated with Epstein‐Barr virus in a patient with AIDS

CNK/T‐cell brain lymphoma associated with Epstein‐Barr virus in a patient with AIDS

Primary Central Nervous System T-Cell Lymphoma in Aids Patients: Case Report and Literature Review

Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases

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