Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins
Harikrishnan Radhakrishnan,
Sherri L. Newmyer,
Marvin A. Ssemadaali
et al.
Abstract:Primary T cell has been transformed into a cell‐based delivery platform that synthesizes complex biologics at the disease site with spatiotemporal resolution. This broadly applicable technology can circumvent toxicities due to systemic administration of biologics that necessitates the use of high doses and may diffuse to the healthy tissues. Its clinical translation, however, has been impeded by manufacturing bottlenecks. In this work, a range of process parameters were investigated for increasing the producti… Show more
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