Primary Systemic Amyloidosis Presenting With Asymmetric Multiple Mononeuropathies

Sadek, Ibrahim M.; Mauermann, Michelle L.; Hayman, Suzanne R.; Spinner, Robert J.; Gertz, Morie A.

doi:10.1200/jco.2009.26.2014

Cited by 9 publications

(1 citation statement)

References 15 publications

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“…1 Immunoglobulin light chain (AL) amyloidosis is a relatively uncommon multisystem disease which can cause neuropathy in a minority of cases 2 and the pattern is usually length-dependent symmetrical polyneuropathy. 3 If nerve involvement presents with multiple mononeuropathies, as can rarely happen in AL amyloidosis, 4,5 accurate diagnosis can be difficult and may require nerve biopsy. Imaging (including ultrasound, magnetic resonance imaging [MRI] and positron emission tomography [PET]) may be useful to identify focal nerve involvement and guide the site of nerve biopsy.…”

Section: Introductionmentioning

confidence: 99%

Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

et al. 2020

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Background: Multiple mononeuropathy is a rare presentation of primary (AL) amyloidosis and nerve biopsy is usually needed for diagnosis. Conventional imaging is useful to identify proximal nerve involvement but may be inadequate. We report a patient with multiple mononeuropathy whose presentation was suggestive of AL amyloid neuropathy and in whom repeated tissue biopsies were negative for amyloid (including two sensory nerves and one muscle). Methods: The patient underwent magnetic resonance imaging (MRI) and whole body 18 F-florbetapir positron emission tomography (PET)/MRI. Results: Whole body 18 F-florbetapir PET/MRI revealed abnormal low-level florbetapir uptake in the right proximal tibial and peroneal nerves, which provided a target for a sciatic bifurcation fascicular nerve biopsy that was diagnostic of AL amyloidosis. Conclusions: 18 F-florbetapir PET/MRI imaging is a promising diagnostic tool for patients with suspected peripheral nerve amyloidosis (including multiple mononeuropathy) in whom conventional imaging and nerve and muscle biopsies miss the pathology.

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Section: Introductionmentioning

confidence: 99%

Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

et al. 2020

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Peripheral Nerve Disorders in Systemic Disease

Mauermann

Burns

2013

Neurological Disorders Due to Systemic Disease

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Neurologic Complications of Plasma Cell Dyscrasias

Naddaf

Mauermann

2017

Cancer Neurology in Clinical Practice

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Primary Systemic Amyloidosis Presenting With Asymmetric Multiple Mononeuropathies

Cited by 9 publications

References 15 publications

Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

Peripheral Nerve Disorders in Systemic Disease

Neurologic Complications of Plasma Cell Dyscrasias

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Primary Systemic Amyloidosis Presenting With Asymmetric Multiple Mononeuropathies

Cited by 9 publications

References 15 publications

Novel imaging techniques using 18F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

Novel imaging techniques using 18F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

Peripheral Nerve Disorders in Systemic Disease

Neurologic Complications of Plasma Cell Dyscrasias

Contact Info

Product

Resources

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Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy

Novel imaging techniques using ¹⁸F‐florbetapir PET/MRI can guide fascicular nerve biopsy in amyloid multiple mononeuropathy